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ENZYME entry: EC 3.4.21.66

Accepted Name
Thermitase.
Alternative Name(s)
Thermophilic Streptomyces serine protease.
Reaction catalysed
Hydrolysis of proteins, including collagen
Comment(s)
  • From Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate.
  • The N-terminal extension of the polypeptide chain relative to subtilisin contributes to calcium-binding and the high thermostability.
  • The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus are closely similar.
  • Belongs to peptidase family S8.
  • Formerly EC 3.4.4.16.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.66
EC2PDB3.4.21.66
ExplorEnz3.4.21.66
PRIAM enzyme-specific profiles3.4.21.66
KEGG Ligand Database for Enzyme Nomenclature3.4.21.66
IUBMB Enzyme Nomenclature3.4.21.66
IntEnz3.4.21.66
MEDLINEFind literature relating to 3.4.21.66
MetaCyc3.4.21.66
UniProtKB/Swiss-Prot
P04072, THET_THEVU

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