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ENZYME

ENZYME entry: EC 3.4.21.88

Accepted Name
repressor LexA
Reaction catalysed
Hydrolysis of Ala-|-Gly bond in repressor LexA
Comment(s)
  • In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  • The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37).
  • Belongs to peptidase family S24.
Cross-references
BRENDA3.4.21.88
EC2PDB3.4.21.88
ExplorEnz3.4.21.88
PRIAM enzyme-specific profiles3.4.21.88
KEGG Ligand Database for Enzyme Nomenclature3.4.21.88
IUBMB Enzyme Nomenclature3.4.21.88
IntEnz3.4.21.88
MEDLINEFind literature relating to 3.4.21.88
MetaCyc3.4.21.88
Rhea expert-curated reactions3.4.21.88
UniProtKB/Swiss-Prot
P61608, LEXA1_GEOSLQ5YP21, LEXA1_NOCFAP0A153, LEXA1_PSEPK
Q87ZB9, LEXA1_PSESMQ8PN77, LEXA1_XANACQ8PBM1, LEXA1_XANCP
Q5GX75, LEXA1_XANORP61609, LEXA2_GEOSLQ5YT43, LEXA2_NOCFA
P59479, LEXA2_PSEPKQ881U0, LEXA2_PSESMP60511, LEXA2_XANAC
Q8P9X2, LEXA2_XANCPQ5GYM5, LEXA2_XANORA3DDH9, LEXA_ACET2
A0LUZ1, LEXA_ACIC1A5G2J1, LEXA_ACICJB9MI78, LEXA_ACIET
B7JBX0, LEXA_ACIF2B5EJ91, LEXA_ACIF5A1W897, LEXA_ACISJ
A3N1B4, LEXA_ACTP2B3GXZ4, LEXA_ACTP7B0BQ48, LEXA_ACTPJ
A6VMQ0, LEXA_ACTSZQ44069, LEXA_AERHHA4STB3, LEXA_AERS4
B6JG34, LEXA_AFIC5Q8UFK2, LEXA_AGRFCQ21U48, LEXA_ALBFT
Q0VQU1, LEXA_ALCBSQ5E209, LEXA_ALIF1B5FCB2, LEXA_ALIFM
B6ENU0, LEXA_ALISLQ0A9N9, LEXA_ALKEHA6TR70, LEXA_ALKMQ
A8MFC9, LEXA_ALKOOB9JX59, LEXA_ALLAMB4S1W7, LEXA_ALTMD
B8JA57, LEXA_ANAD2Q2IIJ0, LEXA_ANADEA7HC61, LEXA_ANADF
B4UCX8, LEXA_ANASKQ5P4A1, LEXA_AROAEA0JUZ2, LEXA_ARTS2
A8I825, LEXA_AZOC5A1K776, LEXA_AZOSBC1DQZ4, LEXA_AZOVD
A0RH75, LEXA_BACAHQ81Y06, LEXA_BACANB7JIC6, LEXA_BACC0
P61606, LEXA_BACC1A7GR32, LEXA_BACCNB9IUL2, LEXA_BACCQ
Q81A92, LEXA_BACCRQ637D7, LEXA_BACCZQ6HFB0, LEXA_BACHK
Q65J42, LEXA_BACLDA9VPX5, LEXA_BACMKA8FDP7, LEXA_BACP2
P31080, LEXA_BACSUA7Z552, LEXA_BACVZQ6G5D9, LEXA_BARHE
Q6FZU5, LEXA_BARQUB2IKM0, LEXA_BEII9A1A2G3, LEXA_BIFAA
B3DQB4, LEXA_BIFLDQ8G4R6, LEXA_BIFLOB7GQ64, LEXA_BIFLS
Q2L247, LEXA_BORA1Q7WCK0, LEXA_BORBRQ7W0T5, LEXA_BORPA
A9IR25, LEXA_BORPDQ7VRY0, LEXA_BORPEQ89KS7, LEXA_BRADU
A5EK34, LEXA_BRASBA4YVE6, LEXA_BRASOC0ZES6, LEXA_BREBN
B2S5Z4, LEXA_BRUA1Q2YRR1, LEXA_BRUA2A6X0K7, LEXA_BRUA4
Q57CZ5, LEXA_BRUABA9M5F7, LEXA_BRUC2C0RJB4, LEXA_BRUMB
Q8YHG1, LEXA_BRUMEA5VQR8, LEXA_BRUO2B0CGU2, LEXA_BRUSI
Q8G0F1, LEXA_BRUSUB1YPM6, LEXA_BURA4A0K775, LEXA_BURCH
B4E8S4, LEXA_BURCJQ0BFL9, LEXA_BURCMQ39GT3, LEXA_BURL3
A9AIX7, LEXA_BURM1A3MJD2, LEXA_BURM7A2S339, LEXA_BURM9
Q62K79, LEXA_BURMAA1V472, LEXA_BURMSB1K0Z6, LEXA_BURO0
Q1BWH8, LEXA_BURO1A3NUV3, LEXA_BURP0Q3JSP6, LEXA_BURP1
A3N959, LEXA_BURP6Q63TX7, LEXA_BURPSQ2SVP7, LEXA_BURTA
A4JE56, LEXA_BURVGA4XL42, LEXA_CALS8Q3ACC4, LEXA_CARHZ
B0SYZ8, LEXA_CAUSKQ9A724, LEXA_CAUVCB3PEX1, LEXA_CELJU
A3PHK4, LEXA_CERS1Q9ZFA4, LEXA_CERS4A4WX64, LEXA_CERS5
Q11HT8, LEXA_CHESBQ1QVT7, LEXA_CHRSDB5EA68, LEXA_CITBB
A8AN85, LEXA_CITK8A5CSL0, LEXA_CLAM3B0RHB3, LEXA_CLASE
Q97I23, LEXA_CLOABA7FUK4, LEXA_CLOB1C3KX30, LEXA_CLOB6
A5I2R7, LEXA_CLOBHC1FNT4, LEXA_CLOBJB1IM63, LEXA_CLOBK
A7GE39, LEXA_CLOBLB1KS97, LEXA_CLOBMQ187P1, LEXA_CLOD6
B9E1Z5, LEXA_CLOK1A5N8J0, LEXA_CLOK5A0Q0N2, LEXA_CLONN
Q0TRD0, LEXA_CLOP1Q8XL81, LEXA_CLOPEQ0STQ8, LEXA_CLOPS
Q895H6, LEXA_CLOTEQ48AA9, LEXA_COLP3P61607, LEXA_CORDI
Q8FPF5, LEXA_COREFA4QET8, LEXA_CORGBQ8NP86, LEXA_CORGL
Q4JV87, LEXA_CORJKA7MPP3, LEXA_CROS8Q1LLW6, LEXA_CUPMC
Q9AGM5, LEXA_CUPNEQ0K9E3, LEXA_CUPNHQ46ZR1, LEXA_CUPPJ
B3R2P9, LEXA_CUPTRQ47EP6, LEXA_DECARO32506, LEXA_DEIRA
A9BWH9, LEXA_DELASB8FIX5, LEXA_DESALB8FWD3, LEXA_DESHD
Q24X76, LEXA_DESHYA4J5P4, LEXA_DESRMA8LMK0, LEXA_DINSH
A7ZUR5, LEXA_ECO24B7UPK4, LEXA_ECO27B7MJ33, LEXA_ECO45
B7LAZ0, LEXA_ECO55P0A7C4, LEXA_ECO57B5Z184, LEXA_ECO5E
B7NSK5, LEXA_ECO7IB7N2Q0, LEXA_ECO81B7M7V6, LEXA_ECO8A
C5A136, LEXA_ECOBWB1XC42, LEXA_ECODHA8A7E3, LEXA_ECOHS
A1AIM0, LEXA_ECOK1Q0TA20, LEXA_ECOL5P0A7C3, LEXA_ECOL6
B1IUK9, LEXA_ECOLCP0A7C2, LEXA_ECOLIB7NFY7, LEXA_ECOLU
B6I5Q8, LEXA_ECOSEB1LPK8, LEXA_ECOSMQ1R3P3, LEXA_ECOUT
C5B718, LEXA_EDWI9A4W5F6, LEXA_ENT38Q834R0, LEXA_ENTFA
B2VKA1, LEXA_ERWT9Q2NA93, LEXA_ERYLHB7LL15, LEXA_ESCF3
B1YE71, LEXA_EXIS2C4L2T2, LEXA_EXISAP0DN68, LEXA_FIBSS
B0S1C5, LEXA_FINM2Q0RDY1, LEXA_FRAAAQ2J779, LEXA_FRACC
A8L6K4, LEXA_FRASNQ5L0C3, LEXA_GEOKAQ39VQ1, LEXA_GEOMG
C6DZY8, LEXA_GEOSMC5D9K3, LEXA_GEOSWA4IMK1, LEXA_GEOTN
A5GAQ4, LEXA_GEOURB8F317, LEXA_GLAP5A9HJ64, LEXA_GLUDA
Q5FNN8, LEXA_GLUOXQ0BTY8, LEXA_GRABCQ7VNI6, LEXA_HAEDU
Q4QME9, LEXA_HAEI8A5UDX6, LEXA_HAEIEA5UHQ3, LEXA_HAEIG
P44858, LEXA_HAEINQ2SKC5, LEXA_HAHCHQ9KAD3, LEXA_HALH5
A1WXU3, LEXA_HALHLA9B5H8, LEXA_HERA2A4G713, LEXA_HERAR
Q0I2G7, LEXA_HISS1B0USF0, LEXA_HISS2Q0C1A3, LEXA_HYPNA
Q5QUP5, LEXA_IDILOA6SXJ3, LEXA_JANMAQ28R71, LEXA_JANSC
B5XXY9, LEXA_KLEP3A6TGV2, LEXA_KLEP7Q1IU64, LEXA_KORVE
Q5FJL4, LEXA_LACACB3WC17, LEXA_LACCBQ1G9M5, LEXA_LACDA
Q049T1, LEXA_LACDBQ044D8, LEXA_LACGAA8YVS7, LEXA_LACH4
P61610, LEXA_LACJOQ03B55, LEXA_LACP3Q88VI6, LEXA_LACPL
Q38W54, LEXA_LATSSQ6AE10, LEXA_LEIXXB0SFV4, LEXA_LEPBA
Q04RH1, LEXA_LEPBJQ053A1, LEXA_LEPBLB0SPA2, LEXA_LEPBP
B1Y250, LEXA_LEPCPP61611, LEXA_LEPICQ8F663, LEXA_LEPIN
B1MZ70, LEXA_LEUCKQ03WX0, LEXA_LEUMMQ1WUI6, LEXA_LIGS1
B2GBL2, LEXA_LIMF3A5VJB8, LEXA_LIMRDB2G6T4, LEXA_LIMRJ
Q92C51, LEXA_LISINC1L2K9, LEXA_LISMCQ720B9, LEXA_LISMF
B8DG25, LEXA_LISMHQ8Y7H7, LEXA_LISMOA0AIA3, LEXA_LISW6
B1HRJ5, LEXA_LYSSCA0L9E2, LEXA_MAGMMQ65UK9, LEXA_MANSM
Q0APU7, LEXA_MARMMA6VX60, LEXA_MARMSA1U269, LEXA_MARN8
Q605V8, LEXA_METCAB8IN87, LEXA_METNOA2SGY5, LEXA_METPP
B1LUJ7, LEXA_METRJB0UGH4, LEXA_METS4B8EK86, LEXA_METSB
Q2RJF5, LEXA_MOOTAA0QIQ3, LEXA_MYCA1B1MCZ5, LEXA_MYCA9
Q7TY15, LEXA_MYCBOA1KM58, LEXA_MYCBPC1AFH9, LEXA_MYCBT
A4TCN9, LEXA_MYCGIB8ZQU5, LEXA_MYCLBQ49848, LEXA_MYCLE
B2HLX8, LEXA_MYCMMP61612, LEXA_MYCPAA0QVY5, LEXA_MYCS2
A3PYG6, LEXA_MYCSJA1UF04, LEXA_MYCSKQ1BA08, LEXA_MYCSS
A5U672, LEXA_MYCTAP9WHR6, LEXA_MYCTOP9WHR7, LEXA_MYCTU
A0PT76, LEXA_MYCUAA1T7V4, LEXA_MYCVPQ1D406, LEXA_MYXXD
Q1QMK3, LEXA_NITHXQ3SRJ0, LEXA_NITWNA1SND2, LEXA_NOCSJ
Q2G6Q5, LEXA_NOVADQ8EQM5, LEXA_OCEIHQ04F93, LEXA_OENOB
Q314F2, LEXA_OLEA2B1ZZZ4, LEXA_OPITPA1R556, LEXA_PAEAT
A1TQ93, LEXA_PARC0A1B3Z0, LEXA_PARDPA7HY01, LEXA_PARL1
Q2W3A5, LEXA_PARM1B2JK89, LEXA_PARP8B2T3L9, LEXA_PARPJ
Q13ZI7, LEXA_PARXLP57917, LEXA_PASMUQ6D9I5, LEXA_PECAS
Q04596, LEXA_PECCCC6DKD2, LEXA_PECCPQ03FU3, LEXA_PEDPA
A5D2J8, LEXA_PELTSQ4FM55, LEXA_PELUBA9BGA3, LEXA_PETMO
B4RBX6, LEXA_PHEZHQ7MZB8, LEXA_PHOLLQ6LVS1, LEXA_PHOPR
A1VNK0, LEXA_POLNAQ129C4, LEXA_POLSJB4EYR3, LEXA_PROMH
Q07267, LEXA_PROREQ15MZ2, LEXA_PSEA6A6V389, LEXA_PSEA7
B7UYS3, LEXA_PSEA8Q02PH1, LEXA_PSEABP37452, LEXA_PSEAE
Q8KT78, LEXA_PSECLB8HG97, LEXA_PSECPA8F429, LEXA_PSELT
A4XSN5, LEXA_PSEMYP0A154, LEXA_PSEPUA1SR67, LEXA_PSYIN
Q8XZU1, LEXA_RALN1B2UAG1, LEXA_RALPJB3PYQ7, LEXA_RHIE6
Q2K8X2, LEXA_RHIECQ1MH39, LEXA_RHIJ3Q98MD2, LEXA_RHILO
B5ZN98, LEXA_RHILWQ92PW3, LEXA_RHIMEB9JEY4, LEXA_RHIR8
P61605, LEXA_RHIRDA5VB97, LEXA_RHIWRP61613, LEXA_RHOCA
B6IST2, LEXA_RHOCSQ2IW99, LEXA_RHOP2Q07NH5, LEXA_RHOP5
P61614, LEXA_RHOPAQ215D1, LEXA_RHOPBQ136C2, LEXA_RHOPS
B3Q6P2, LEXA_RHOPTQ2RT47, LEXA_RHORTQ163X5, LEXA_ROSDO
A5UQF5, LEXA_ROSS1Q5LRH4, LEXA_RUEPOQ1GHJ8, LEXA_RUEST
B8I2Q1, LEXA_RUMCHQ21JT2, LEXA_SACD2B5F1Q6, LEXA_SALA4
A9MGP6, LEXA_SALARQ57GZ0, LEXA_SALCHB5FQR1, LEXA_SALDC
B5QZ62, LEXA_SALEPB5R7T6, LEXA_SALG2B4TDM0, LEXA_SALHS
B4T1T2, LEXA_SALNSQ5PL14, LEXA_SALPAA9N1L6, LEXA_SALPB
C0Q514, LEXA_SALPCB5BJW0, LEXA_SALPKB4TQQ5, LEXA_SALSV
P0A274, LEXA_SALTIP0A273, LEXA_SALTYA8GKB4, LEXA_SERP5
A1SBC7, LEXA_SHEAMB8ECL9, LEXA_SHEB2A3CYX7, LEXA_SHEB5
A6WU05, LEXA_SHEB8A9KUW8, LEXA_SHEB9Q12ID6, LEXA_SHEDO
Q089E2, LEXA_SHEFNB0TNT3, LEXA_SHEHHA3Q951, LEXA_SHELP
Q8E8Q8, LEXA_SHEONA8H9S0, LEXA_SHEPAA4YC04, LEXA_SHEPC
B8CUX0, LEXA_SHEPWA0L2D8, LEXA_SHESAA8FPP0, LEXA_SHESH
Q0HDL5, LEXA_SHESMQ0HPW6, LEXA_SHESRA1RE93, LEXA_SHESW
B1KM68, LEXA_SHEWMB2TX73, LEXA_SHIB3Q31TV1, LEXA_SHIBS
Q327V0, LEXA_SHIDSQ0SXR0, LEXA_SHIF8P0A7C5, LEXA_SHIFL
Q3YUU1, LEXA_SHISSQ5WG03, LEXA_SHOC1A6U971, LEXA_SINMW
Q2NR09, LEXA_SODGMA9F881, LEXA_SORC5Q1GUX2, LEXA_SPHAL
A7X1Z4, LEXA_STAA1Q2FH94, LEXA_STAA3Q2FYU1, LEXA_STAA8
Q2YXS8, LEXA_STAABQ9L4P1, LEXA_STAACA6QGP1, LEXA_STAAE
P65819, LEXA_STAAMP65820, LEXA_STAANQ6GH67, LEXA_STAAR
Q6G9L9, LEXA_STAASQ93SM0, LEXA_STAAWB9DP69, LEXA_STACT
Q5HPK2, LEXA_STAEQQ4L648, LEXA_STAHJQ49XD4, LEXA_STAS1
Q82KE0, LEXA_STRAWO86847, LEXA_STRCLO69979, LEXA_STRCO
B4SRA9, LEXA_STRM5Q67NM2, LEXA_SYMTHQ3A3S5, LEXA_SYNC1
A0LGS1, LEXA_SYNFMQ0AY82, LEXA_SYNWWC5BIH2, LEXA_TERTT
B7IDD1, LEXA_THEABQ47MY4, LEXA_THEFYA6LM87, LEXA_THEM4
O33927, LEXA_THEMAO86948, LEXA_THENEB9K9N0, LEXA_THENN
A5IN94, LEXA_THEP1B1L838, LEXA_THESQQ3SIT9, LEXA_THIDA
C4L7X7, LEXA_TOLATC5CKV7, LEXA_VARPSA1WSJ3, LEXA_VEREI
P0DOW5, LEXA_VERSIB7VM94, LEXA_VIBA3A7N0W6, LEXA_VIBC1
A5F4F6, LEXA_VIBC3Q9KVP9, LEXA_VIBCHC3LPT4, LEXA_VIBCM
Q87KN2, LEXA_VIBPAQ8DD47, LEXA_VIBVUQ7MQ85, LEXA_VIBVY
Q93MQ9, LEXA_XANCAP60512, LEXA_XANCIA7INJ8, LEXA_XANP2
B2I679, LEXA_XYLF2Q9PH24, LEXA_XYLFAB0U1K7, LEXA_XYLFM
Q87F45, LEXA_XYLFTA1JRT9, LEXA_YERE8A7FN96, LEXA_YERP3
Q1C0U1, LEXA_YERPAB2K1U7, LEXA_YERPBQ8ZJ16, LEXA_YERPE
A9R273, LEXA_YERPGQ1CE98, LEXA_YERPNA4TRU5, LEXA_YERPP
Q66FG7, LEXA_YERPSB1JNE3, LEXA_YERPYQ5NR31, LEXA_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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