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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Alternative Name(s)
Extracellular lactococcal proteinase.
Lactococcal cell envelope-associated proteinase.
Wall-associated serine proteinase.
Reaction catalysed
Endopeptidase activity with very broad specificity, although some subsite preference have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position. Best known for its action on caseins, although it has been shown to hydrolyze hemoglobin and oxidized insulin B-chain
  • Responsible for the hydrolysis of casein in milk and the provision of peptides essential for cell growth.
  • Specificity differences between lactocepins from different starter strains may be partly responsible for imparating different flavor qualities to cheese.
  • Belongs to peptidase family S8.
PRIAM enzyme-specific profiles3.4.21.96
KEGG Ligand Database for Enzyme Nomenclature3.4.21.96
IUBMB Enzyme Nomenclature3.4.21.96
MEDLINEFind literature relating to
P16271, P1P_LACLC;  P15293, P2P_LACLC;  Q02470, P2P_LACPA;  
P15292, P3P_LACLS;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-