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ENZYME entry: EC 3.4.21.96

Accepted Name
Lactocepin.
Alternative Name(s)
Extracellular lactococcal proteinase.
Lactococcal cell envelope-associated proteinase.
Wall-associated serine proteinase.
Reaction catalysed
Endopeptidase activity with very broad specificity, although some subsite preference have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position. Best known for its action on caseins, although it has been shown to hydrolyze hemoglobin and oxidized insulin B-chain
Comment(s)
  • Responsible for the hydrolysis of casein in milk and the provision of peptides essential for cell growth.
  • Specificity differences between lactocepins from different starter strains may be partly responsible for imparating different flavor qualities to cheese.
  • Belongs to peptidase family S8.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.96
EC2PDB3.4.21.96
ExplorEnz3.4.21.96
PRIAM enzyme-specific profiles3.4.21.96
KEGG Ligand Database for Enzyme Nomenclature3.4.21.96
IUBMB Enzyme Nomenclature3.4.21.96
IntEnz3.4.21.96
MEDLINEFind literature relating to 3.4.21.96
MetaCyc3.4.21.96
UniProtKB/Swiss-Prot
P16271, P1P_LACLC;  P15293, P2P_LACLC;  Q02470, P2P_LACPA;  
P15292, P3P_LACLS;  

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