A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.98
| Accepted Name |
|---|
| Hepacivirin.
|
| Alternative Name(s) |
|---|
| Cpro-2. |
| Hepatitis C virus NS3 serine proteinase. |
| Reaction catalysed |
|---|
| Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' |
| Comment(s) |
|---|
- Encoded by the genome of the viruses of the hepatitis C group,
and contributes to the maturation of the precursor polyproteins.
- The enzyme is greatly activated by binding of the 54-residue NS4A
'cofactor' protein also derived from the viral polyprotein.
- Belongs to peptidase family S29.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.98 |
| EC2PDB | 3.4.21.98 |
| ExplorEnz | 3.4.21.98 |
| PRIAM enzyme-specific profiles | 3.4.21.98 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.98 |
| IUBMB Enzyme Nomenclature | 3.4.21.98 |
| IntEnz | 3.4.21.98 |
| MEDLINE | Find literature relating to 3.4.21.98 |
| MetaCyc | 3.4.21.98 |
| UniProtKB/Swiss-Prot |
| Q69422, POLG_GBVB; | P26664, POLG_HCV1; | Q5I2N3, POLG_HCV6A; |
| Q68749, POLG_HCVBB; | P26663, POLG_HCVBK; | Q9WMX2, POLG_HCVCO; |
| O39929, POLG_HCVED; | O39927, POLG_HCVEU; | O39928, POLG_HCVEV; |
| P27958, POLG_HCVH; | Q81754, POLG_HCVH9; | Q913D4, POLG_HCVIN; |
| Q03463, POLG_HCVJ1; | O92972, POLG_HCVJ4; | P26660, POLG_HCVJ6; |
| P26661, POLG_HCVJ8; | P26662, POLG_HCVJA; | Q99IB8, POLG_HCVJF; |
| Q68801, POLG_HCVJK; | Q68798, POLG_HCVJL; | Q9DHD6, POLG_HCVJP; |
| Q00269, POLG_HCVJT; | Q81495, POLG_HCVK3; | Q81258, POLG_HCVNZ; |
| Q913V3, POLG_HCVR6; | O91936, POLG_HCVSA; | O92529, POLG_HCVT5; |
| Q81487, POLG_HCVTR; | P29846, POLG_HCVTW; | Q9QAX1, POLG_HCVVA; |
| O92530, POLG_HCVVN; | O92531, POLG_HCVVO; | O92532, POLG_HCVVP; |
|
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