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ENZYME entry: EC 3.4.21.98

Accepted Name
hepacivirin.
Alternative Name(s)
Cpro-2.
hepatitis C virus NS3 serine proteinase.
Reaction catalysed
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'
Comment(s)
  • Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins.
  • The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein.
  • Belongs to peptidase family S29.
Cross-references
BRENDA3.4.21.98
EC2PDB3.4.21.98
ExplorEnz3.4.21.98
PRIAM enzyme-specific profiles3.4.21.98
KEGG Ligand Database for Enzyme Nomenclature3.4.21.98
IUBMB Enzyme Nomenclature3.4.21.98
IntEnz3.4.21.98
MEDLINEFind literature relating to 3.4.21.98
MetaCyc3.4.21.98
Rhea expert-curated reactions3.4.21.98
UniProtKB/Swiss-Prot
Q69422, POLG_GBVB;  P26664, POLG_HCV1;  Q5I2N3, POLG_HCV6A;  
P27958, POLG_HCV77;  Q68749, POLG_HCVBB;  P26663, POLG_HCVBK;  
Q9WMX2, POLG_HCVCO;  O39929, POLG_HCVED;  O39927, POLG_HCVEU;  
O39928, POLG_HCVEV;  Q81754, POLG_HCVH9;  Q913D4, POLG_HCVIN;  
Q03463, POLG_HCVJ1;  O92972, POLG_HCVJ4;  P26660, POLG_HCVJ6;  
P26661, POLG_HCVJ8;  P26662, POLG_HCVJA;  Q99IB8, POLG_HCVJF;  
Q68801, POLG_HCVJK;  Q68798, POLG_HCVJL;  Q9DHD6, POLG_HCVJP;  
Q00269, POLG_HCVJT;  Q81495, POLG_HCVK3;  Q81258, POLG_HCVNZ;  
Q913V3, POLG_HCVR6;  O91936, POLG_HCVSA;  O92529, POLG_HCVT5;  
Q81487, POLG_HCVTR;  P29846, POLG_HCVTW;  Q9QAX1, POLG_HCVVA;  
O92530, POLG_HCVVN;  O92531, POLG_HCVVO;  O92532, POLG_HCVVP;  

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