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ENZYME

ENZYME entry: EC 3.4.21.98

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.98
Accepted Name
hepacivirin
Alternative Name(s)
Cpro-2
hepatitis C virus NS3 serine proteinase
Reaction catalysed
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'
Comment(s)
  • Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins.
  • The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein.
  • Belongs to peptidase family S29.
Cross-references
BRENDA3.4.21.98
EC2PDB3.4.21.98
ExplorEnz3.4.21.98
KEGG Ligand Database for Enzyme Nomenclature3.4.21.98
IUBMB Enzyme Nomenclature3.4.21.98
MEDLINEFind literature relating to 3.4.21.98
MetaCyc3.4.21.98
Rhea expert-curated reactions3.4.21.98
UniProtKB/Swiss-Prot
Q69422, POLG_GBVBP26664, POLG_HCV1Q5I2N3, POLG_HCV6A
P27958, POLG_HCV77Q68749, POLG_HCVBBP26663, POLG_HCVBK
Q9WMX2, POLG_HCVCOO39929, POLG_HCVEDO39927, POLG_HCVEU
O39928, POLG_HCVEVQ81754, POLG_HCVH9Q913D4, POLG_HCVIN
Q03463, POLG_HCVJ1O92972, POLG_HCVJ4P26660, POLG_HCVJ6
P26661, POLG_HCVJ8P26662, POLG_HCVJAQ99IB8, POLG_HCVJF
Q68801, POLG_HCVJKQ68798, POLG_HCVJLQ9DHD6, POLG_HCVJP
Q00269, POLG_HCVJTQ81495, POLG_HCVK3Q81258, POLG_HCVNZ
Q913V3, POLG_HCVR6O91936, POLG_HCVSAO92529, POLG_HCVT5
Q81487, POLG_HCVTRP29846, POLG_HCVTWQ9QAX1, POLG_HCVVA
O92530, POLG_HCVVNO92531, POLG_HCVVOO92532, POLG_HCVVP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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