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ENZYME

ENZYME entry: EC 3.4.22.36

PURL: https://purl.expasy.org/enzyme/EC/3.4.22.36
Accepted Name
caspase-1
Alternative Name(s)
interleukin-1beta convertase
interleukin-1 beta convertase precursor
interleukin 1beta-converting endopeptidase
interleukin 1beta converting enzyme
prointerleukin 1beta protease
pro-interleukin 1beta proteinase
Reaction catalysed
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-
Comment(s)
  • Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice.
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation.
  • Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.
  • Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
  • Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans.
  • Belongs to peptidase family C14.
Cross-references
BRENDA3.4.22.36
EC2PDB3.4.22.36
ExplorEnz3.4.22.36
KEGG Ligand Database for Enzyme Nomenclature3.4.22.36
IUBMB Enzyme Nomenclature3.4.22.36
MEDLINEFind literature relating to 3.4.22.36
MetaCyc3.4.22.36
Rhea expert-curated reactions3.4.22.36
UniProtKB/Swiss-Prot
P55865, CAS1A_XENLAP55867, CAS1B_XENLAQ9MZV7, CASP1_CANLF
Q9MZV6, CASP1_FELCAQ9TV13, CASP1_HORSEP29466, CASP1_HUMAN
P29452, CASP1_MOUSEQ9N2I1, CASP1_PIGP43527, CASP1_RAT
Q9I9L7, CASPA_DANREG5EBM1, CSP1_CAEEL

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