ENZYME entry: EC 3.4.22.36
Accepted Name |
Caspase-1.
|
Alternative Name(s) |
Interleukin 1-beta converting enzyme. |
Interleukin 1-beta-converting endopeptidase. |
Interleukin-1 beta convertase precursor. |
Interleukin-1-beta convertase. |
Pro-interleukin 1-beta proteinase. |
Prointerleukin 1-beta protease. |
Reaction catalysed |
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- |
Comment(s) |
- Part of the family of inflammatory-caspases, which also includes
caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and
caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in
mice.
- Contains a caspase-recruitment domain (CARD) in its N-terminal
prodomain, which plays a role in procaspase activation.
- Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1-
beta, a potent mediator of inflammation.
- Also activates the proinflammatory cytokine, IL-18, which is also
known as interferon-gamma-inducing factor.
- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
- Caspase-11 plays a critical role in the activation of caspase-1 in
mice whereas caspase-4 enhances its activation in humans.
- Belongs to peptidase family C14.
|
Cross-references |
PROSITE | PDOC00864 |
BRENDA | 3.4.22.36 |
EC2PDB | 3.4.22.36 |
ExplorEnz | 3.4.22.36 |
PRIAM enzyme-specific profiles | 3.4.22.36 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.36 |
IUBMB Enzyme Nomenclature | 3.4.22.36 |
IntEnz | 3.4.22.36 |
MEDLINE | Find literature relating to 3.4.22.36 |
MetaCyc | 3.4.22.36 |
Rhea expert-curated reactions | 3.4.22.36 |
UniProtKB/Swiss-Prot |
P55865, CAS1A_XENLA; | P55867, CAS1B_XENLA; | Q9MZV7, CASP1_CANLF; |
Q9MZV6, CASP1_FELCA; | Q9TV13, CASP1_HORSE; | P29466, CASP1_HUMAN; |
P29452, CASP1_MOUSE; | Q9N2I1, CASP1_PIG; | P43527, CASP1_RAT; |
Q9I9L7, CASPA_DANRE; | G5EBM1, CSP1_CAEEL; |
|
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