ENZYME

ENZYME entry: EC 3.4.22.36

Accepted Name

Caspase-1.

Alternative Name(s)

Interleukin 1-beta converting enzyme.

Interleukin 1-beta-converting endopeptidase.

Interleukin-1 beta convertase precursor.

Interleukin-1-beta convertase.

Pro-interleukin 1-beta proteinase.

Prointerleukin 1-beta protease.

Reaction catalysed

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-

Comment(s)

Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice.
Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation.
Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.
Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans.
Belongs to peptidase family C14.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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