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ENZYME entry: EC 3.4.22.36

Accepted Name
caspase-1.
Alternative Name(s)
interleukin-1beta convertase.
interleukin-1 beta convertase precursor.
interleukin 1beta-converting endopeptidase.
interleukin 1beta converting enzyme.
prointerleukin 1beta protease.
pro-interleukin 1beta proteinase.
Reaction catalysed
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-
Comment(s)
  • Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice.
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation.
  • Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.
  • Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
  • Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans.
  • Belongs to peptidase family C14.
Cross-references
BRENDA3.4.22.36
EC2PDB3.4.22.36
ExplorEnz3.4.22.36
PRIAM enzyme-specific profiles3.4.22.36
KEGG Ligand Database for Enzyme Nomenclature3.4.22.36
IUBMB Enzyme Nomenclature3.4.22.36
IntEnz3.4.22.36
MEDLINEFind literature relating to 3.4.22.36
MetaCyc3.4.22.36
Rhea expert-curated reactions3.4.22.36
UniProtKB/Swiss-Prot
P55865, CAS1A_XENLA;  P55867, CAS1B_XENLA;  Q9MZV7, CASP1_CANLF;  
Q9MZV6, CASP1_FELCA;  Q9TV13, CASP1_HORSE;  P29466, CASP1_HUMAN;  
P29452, CASP1_MOUSE;  Q9N2I1, CASP1_PIG;  P43527, CASP1_RAT;  
Q9I9L7, CASPA_DANRE;  G5EBM1, CSP1_CAEEL;  

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