ENZYME entry: EC 3.4.22.64
Accepted Name |
caspase-11.
|
Alternative Name(s) |
CASP-11. |
Reaction catalysed |
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|- |
Comment(s) |
- Part of the family of inflammatory-caspases, which also includes
caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5
(EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in
mice.
- Contains a caspase-recruitment domain (CARD) in its N-terminal
prodomain, which plays a role in procaspase activation.
- Like caspase-5, but unlike caspase-4, this enzyme can be induced by
lipopolysaccharide.
- Not only activates caspase-1, which is required for the maturation of
proinflammatory cytokines such as interleukin-1beta (IL-1beta) and
IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to
cellular apoptosis under pathological conditions.
- Belongs to peptidase family C14.
|
Cross-references |
BRENDA | 3.4.22.64 |
EC2PDB | 3.4.22.64 |
ExplorEnz | 3.4.22.64 |
PRIAM enzyme-specific profiles | 3.4.22.64 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.64 |
IUBMB Enzyme Nomenclature | 3.4.22.64 |
IntEnz | 3.4.22.64 |
MEDLINE | Find literature relating to 3.4.22.64 |
MetaCyc | 3.4.22.64 |
Rhea expert-curated reactions | 3.4.22.64 |
UniProtKB/Swiss-Prot |
|
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