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ENZYME entry: EC 3.4.22.64

Accepted Name
caspase-11.
Alternative Name(s)
CASP-11.
Reaction catalysed
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|-
Comment(s)
  • Part of the family of inflammatory-caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice.
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide.
  • Not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions.
  • Belongs to peptidase family C14.
Cross-references
BRENDA3.4.22.64
EC2PDB3.4.22.64
ExplorEnz3.4.22.64
PRIAM enzyme-specific profiles3.4.22.64
KEGG Ligand Database for Enzyme Nomenclature3.4.22.64
IUBMB Enzyme Nomenclature3.4.22.64
IntEnz3.4.22.64
MEDLINEFind literature relating to 3.4.22.64
MetaCyc3.4.22.64
Rhea expert-curated reactions3.4.22.64
UniProtKB/Swiss-Prot
P70343, CASP4_MOUSE

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