Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.22.64

Accepted Name
Caspase-11.
Alternative Name(s)
CASP-11.
Reaction catalysed
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|-
Comment(s)
  • Part of the family of inflammatory-caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice.
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide.
  • Not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1-beta (IL-1-beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions.
  • Belongs to peptidase family C14.
Cross-references
PROSITEPDOC00864
BRENDA3.4.22.64
EC2PDB3.4.22.64
ExplorEnz3.4.22.64
PRIAM enzyme-specific profiles3.4.22.64
KEGG Ligand Database for Enzyme Nomenclature3.4.22.64
IUBMB Enzyme Nomenclature3.4.22.64
IntEnz3.4.22.64
MEDLINEFind literature relating to 3.4.22.64
MetaCyc3.4.22.64
UniProtKB/Swiss-Prot
P70343, CASP4_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-