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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Reaction catalysed
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-
  • Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses.
  • Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue.
  • The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory.
  • Belongs to peptidase family C28.
PRIAM enzyme-specific profiles3.4.22.46
KEGG Ligand Database for Enzyme Nomenclature3.4.22.46
IUBMB Enzyme Nomenclature3.4.22.46
MEDLINEFind literature relating to
P03306, POLG_FMDV1;  P03307, POLG_FMDV5;  P03308, POLG_FMDVA;  
P03309, POLG_FMDVC;  P03310, POLG_FMDVI;  P03305, POLG_FMDVO;  
P03311, POLG_FMDVS;  P15072, POLG_FMDVT;  P49303, POLG_FMDVZ;  

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