ENZYME entry: EC 3.4.22.49
| Accepted Name |
|---|
| Separase.
|
| Alternative Name(s) |
|---|
| Separin. |
| Reaction catalysed |
|---|
| All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage |
| Comment(s) |
|---|
- In both Saccharomyces cerevisiae and human cells, cleavage of the
cohesin subunit Scc1 by separase is required for sister chromatid
separation in mitosis.
- S.cerevisiae separase is also known to cleave the Rec8 subunit of a
meiotic cohesin complex and the kinetochore protein Slk19.
- Belongs to peptidase family C50.
|
| Cross-references |
|---|
| BRENDA | 3.4.22.49 |
| EC2PDB | 3.4.22.49 |
| ExplorEnz | 3.4.22.49 |
| PRIAM enzyme-specific profiles | 3.4.22.49 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.49 |
| IUBMB Enzyme Nomenclature | 3.4.22.49 |
| IntEnz | 3.4.22.49 |
| MEDLINE | Find literature relating to 3.4.22.49 |
| MetaCyc | 3.4.22.49 |
| Rhea expert-curated reactions | 3.4.22.49 |
| UniProtKB/Swiss-Prot |
|
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