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ENZYME entry: EC 3.4.22.49

Accepted Name
Separase.
Alternative Name(s)
Separin.
Reaction catalysed
All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
Comment(s)
  • In both Saccharomyces cerevisiae and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis.
  • S.cerevisiae separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19.
  • Belongs to peptidase family C50.
Cross-references
BRENDA3.4.22.49
EC2PDB3.4.22.49
ExplorEnz3.4.22.49
PRIAM enzyme-specific profiles3.4.22.49
KEGG Ligand Database for Enzyme Nomenclature3.4.22.49
IUBMB Enzyme Nomenclature3.4.22.49
IntEnz3.4.22.49
MEDLINEFind literature relating to 3.4.22.49
MetaCyc3.4.22.49
UniProtKB/Swiss-Prot
P33144, BIMB_EMENI;  P18296, CUT1_SCHPO;  Q5IBC5, ESP1_ARATH;  
Q03018, ESP1_YEAST;  Q14674, ESPL1_HUMAN;  P60330, ESPL1_MOUSE;  
G5ED39, SEP1_CAEEL;  

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