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ENZYME entry: EC 3.4.22.54

Accepted Name
Calpain-3.
Alternative Name(s)
Calcium-activated neutral proteinase 3.
Calpain L3.
Calpain p94.
CANP 3.
CAPN3.
Muscle-specific calcium-activated neutral protease 3.
Reaction catalysed
Broad endopeptidase activity
Cofactor(s)
Ca(2+).
Comment(s)
  • Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site.
  • Substrates include the protein itself and connectin/titin.
  • Belongs to peptidase family C2.
Cross-references
PROSITEPDOC00126 ; PDOC50203
BRENDA3.4.22.54
EC2PDB3.4.22.54
ExplorEnz3.4.22.54
PRIAM enzyme-specific profiles3.4.22.54
KEGG Ligand Database for Enzyme Nomenclature3.4.22.54
IUBMB Enzyme Nomenclature3.4.22.54
IntEnz3.4.22.54
MEDLINEFind literature relating to 3.4.22.54
MetaCyc3.4.22.54
Rhea expert-curated reactions3.4.22.54
UniProtKB/Swiss-Prot
P51186, CAN3_BOVIN;  Q92177, CAN3_CHICK;  P20807, CAN3_HUMAN;  
Q9GLG7, CAN3_MACFA;  Q64691, CAN3_MOUSE;  P43368, CAN3_PIG;  
P16259, CAN3_RAT;  Q9TTH8, CAN3_SHEEP;  

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