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ENZYME

ENZYME entry: EC 3.4.22.54

Accepted Name
calpain-3
Alternative Name(s)
calcium-activated neutral proteinase 3
calpain L3
calpain p94
CANP 3
CAPN3
muscle-specific calcium-activated neutral protease 3
Reaction catalysed
Broad endopeptidase activity
Comment(s)
  • Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site.
  • Substrates include the protein itself and connectin/titin.
  • Belongs to peptidase family C2.
Cross-references
BRENDA3.4.22.54
EC2PDB3.4.22.54
ExplorEnz3.4.22.54
PRIAM enzyme-specific profiles3.4.22.54
KEGG Ligand Database for Enzyme Nomenclature3.4.22.54
IUBMB Enzyme Nomenclature3.4.22.54
IntEnz3.4.22.54
MEDLINEFind literature relating to 3.4.22.54
MetaCyc3.4.22.54
Rhea expert-curated reactions3.4.22.54
UniProtKB/Swiss-Prot
P51186, CAN3_BOVINQ92177, CAN3_CHICKP20807, CAN3_HUMAN
Q9GLG7, CAN3_MACFAQ64691, CAN3_MOUSEP43368, CAN3_PIG
P16259, CAN3_RATQ9TTH8, CAN3_SHEEP

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