ENZYME entry: EC 3.4.22.54
Accepted Name |
Calpain-3.
|
Alternative Name(s) |
Calcium-activated neutral proteinase 3. |
Calpain L3. |
Calpain p94. |
CANP 3. |
CAPN3. |
Muscle-specific calcium-activated neutral protease 3. |
Reaction catalysed |
Broad endopeptidase activity |
Cofactor(s) |
Ca(2+).
|
Comment(s) |
- Activated by autoproteolytic cleavage of insertion sequence 1 (IS1),
which allows substrates and inhibitors gain access to the active
site.
- Substrates include the protein itself and connectin/titin.
- Belongs to peptidase family C2.
|
Cross-references |
PROSITE | PDOC00126 ; PDOC50203 |
BRENDA | 3.4.22.54 |
EC2PDB | 3.4.22.54 |
ExplorEnz | 3.4.22.54 |
PRIAM enzyme-specific profiles | 3.4.22.54 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.54 |
IUBMB Enzyme Nomenclature | 3.4.22.54 |
IntEnz | 3.4.22.54 |
MEDLINE | Find literature relating to 3.4.22.54 |
MetaCyc | 3.4.22.54 |
Rhea expert-curated reactions | 3.4.22.54 |
UniProtKB/Swiss-Prot |
|
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