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ENZYME entry: EC 3.4.22.68

Accepted Name
Ulp1 peptidase.
Alternative Name(s)
Smt3-protein conjugate proteinase.
Ubl-specific protease 1.
Ulp1.
Ulp1 endopeptidase.
Ulp1 protease.
Reaction catalysed
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
Comment(s)
  • The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions.
  • Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle.
  • Belongs to peptidase family C48.
Cross-references
PROSITEPDOC50600
BRENDA3.4.22.68
EC2PDB3.4.22.68
ExplorEnz3.4.22.68
PRIAM enzyme-specific profiles3.4.22.68
KEGG Ligand Database for Enzyme Nomenclature3.4.22.68
IUBMB Enzyme Nomenclature3.4.22.68
IntEnz3.4.22.68
MEDLINEFind literature relating to 3.4.22.68
MetaCyc3.4.22.68
UniProtKB/Swiss-Prot
Q94F30, ESD4_ARATH;  Q02724, ULP1_YEAST;  

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