ENZYME entry: EC 3.4.22.68
Accepted Name |
Ulp1 peptidase.
|
Alternative Name(s) |
Smt3-protein conjugate proteinase. |
Ubl-specific protease 1. |
Ulp1. |
Ulp1 endopeptidase. |
Ulp1 protease. |
Reaction catalysed |
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein |
Comment(s) |
- The enzyme from Saccharomyces cerevisiae can also recognize small
ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both
SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation
(epsilon-linked peptide bonds) reactions.
- Ulp1 has several functions, including an essential role in
chromosomal segregation and progression of the cell cycle through the
G2/M phase of the cell cycle.
- Belongs to peptidase family C48.
|
Cross-references |
BRENDA | 3.4.22.68 |
EC2PDB | 3.4.22.68 |
ExplorEnz | 3.4.22.68 |
PRIAM enzyme-specific profiles | 3.4.22.68 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.68 |
IUBMB Enzyme Nomenclature | 3.4.22.68 |
IntEnz | 3.4.22.68 |
MEDLINE | Find literature relating to 3.4.22.68 |
MetaCyc | 3.4.22.68 |
Rhea expert-curated reactions | 3.4.22.68 |
UniProtKB/Swiss-Prot |
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