ENZYME entry: EC 3.4.22.68
| Accepted Name |
|---|
| Ulp1 peptidase.
|
| Alternative Name(s) |
|---|
| Smt3-protein conjugate proteinase. |
| Ubl-specific protease 1. |
| Ulp1. |
| Ulp1 endopeptidase. |
| Ulp1 protease. |
| Reaction catalysed |
|---|
| Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein |
| Comment(s) |
|---|
- The enzyme from Saccharomyces cerevisiae can also recognize small
ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both
SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation
(epsilon-linked peptide bonds) reactions.
- Ulp1 has several functions, including an essential role in
chromosomal segregation and progression of the cell cycle through the
G2/M phase of the cell cycle.
- Belongs to peptidase family C48.
|
| Cross-references |
|---|
| PROSITE | PDOC50600 |
| BRENDA | 3.4.22.68 |
| EC2PDB | 3.4.22.68 |
| ExplorEnz | 3.4.22.68 |
| PRIAM enzyme-specific profiles | 3.4.22.68 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.68 |
| IUBMB Enzyme Nomenclature | 3.4.22.68 |
| IntEnz | 3.4.22.68 |
| MEDLINE | Find literature relating to 3.4.22.68 |
| MetaCyc | 3.4.22.68 |
| Rhea expert-curated reactions | 3.4.22.68 |
| UniProtKB/Swiss-Prot |
|
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