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ENZYME

ENZYME entry: EC 3.4.22.69

Accepted Name
SARS coronavirus main proteinase
Alternative Name(s)
3C-like protease
3cLpro
coronavirus 3C-like protease
SARS coronavirus main protease
SARS-CoV 3CLpro enzyme
severe acute respiratory syndrome coronavirus main protease
Reaction catalysed
TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position
Comment(s)
  • SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing.
  • Belongs to peptidase family C30.
Cross-references
BRENDA3.4.22.69
EC2PDB3.4.22.69
ExplorEnz3.4.22.69
PRIAM enzyme-specific profiles3.4.22.69
KEGG Ligand Database for Enzyme Nomenclature3.4.22.69
IUBMB Enzyme Nomenclature3.4.22.69
IntEnz3.4.22.69
MEDLINEFind literature relating to 3.4.22.69
MetaCyc3.4.22.69
Rhea expert-curated reactions3.4.22.69
UniProtKB/Swiss-Prot
P0C6X7, R1AB_SARSP0DTD1, R1AB_SARS2P0C6F7, R1A_BC133
P0C6F5, R1A_BC279P0C6F8, R1A_BCHK3P0C6T4, R1A_BCHK4
P0C6T5, R1A_BCHK5P0C6T6, R1A_BCHK9P0C6T7, R1A_BCRP3
P0C6T8, R1A_CVBENP0C6T9, R1A_CVBLUP0C6U0, R1A_CVBM
P0C6U1, R1A_CVBQP0C6U3, R1A_CVHN1P0C6U4, R1A_CVHN2
P0C6U5, R1A_CVHN5P0C6U7, R1A_CVHOCP0C6U9, R1A_CVM2
P0C6V0, R1A_CVMA5P0C6V1, R1A_CVMJHK9N638, R1A_MERS1
P0C6U8, R1A_SARSP0DTC1, R1A_SARS2

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