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ENZYME entry: EC 3.4.22.69

Accepted Name
SARS coronavirus main proteinase.
Alternative Name(s)
3C-like protease.
3cLpro.
Coronavirus 3C-like protease.
SARS coronavirus main protease.
SARS-CoV 3CLpro enzyme.
Severe acute respiratory syndrome coronavirus main protease.
Reaction catalysed
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position
Comment(s)
  • SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing.
  • Belongs to peptidase family C30.
Cross-references
BRENDA3.4.22.69
EC2PDB3.4.22.69
ExplorEnz3.4.22.69
PRIAM enzyme-specific profiles3.4.22.69
KEGG Ligand Database for Enzyme Nomenclature3.4.22.69
IUBMB Enzyme Nomenclature3.4.22.69
IntEnz3.4.22.69
MEDLINEFind literature relating to 3.4.22.69
MetaCyc3.4.22.69
UniProtKB/Swiss-Prot
P0C6W1, R1AB_BC133;  P0C6V9, R1AB_BC279;  P0C6W2, R1AB_BCHK3;  
P0C6W3, R1AB_BCHK4;  P0C6W4, R1AB_BCHK5;  P0C6W5, R1AB_BCHK9;  
P0C6W6, R1AB_BCRP3;  P0C6W7, R1AB_CVBEN;  P0C6W8, R1AB_CVBLU;  
P0C6W9, R1AB_CVBM;  P0C6X0, R1AB_CVBQ;  K9N7C7, R1AB_CVEMC;  
P0C6X2, R1AB_CVHN1;  P0C6X3, R1AB_CVHN2;  P0C6X4, R1AB_CVHN5;  
P0C6X6, R1AB_CVHOC;  P0C6X7, R1AB_CVHSA;  P0C6X8, R1AB_CVM2;  
P0C6X9, R1AB_CVMA5;  P0C6Y0, R1AB_CVMJH;  P0C6F7, R1A_BC133;  
P0C6F5, R1A_BC279;  P0C6F8, R1A_BCHK3;  P0C6T4, R1A_BCHK4;  
P0C6T5, R1A_BCHK5;  P0C6T6, R1A_BCHK9;  P0C6T7, R1A_BCRP3;  
P0C6T8, R1A_CVBEN;  P0C6T9, R1A_CVBLU;  P0C6U0, R1A_CVBM;  
P0C6U1, R1A_CVBQ;  K9N638, R1A_CVEMC;  P0C6U3, R1A_CVHN1;  
P0C6U4, R1A_CVHN2;  P0C6U5, R1A_CVHN5;  P0C6U7, R1A_CVHOC;  
P0C6U8, R1A_CVHSA;  P0C6U9, R1A_CVM2;  P0C6V0, R1A_CVMA5;  
P0C6V1, R1A_CVMJH;  

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