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ENZYME entry: EC

Accepted Name
SARS coronavirus main proteinase.
Alternative Name(s)
3C-like protease.
coronavirus 3C-like protease.
SARS coronavirus main protease.
SARS-CoV 3CLpro enzyme.
severe acute respiratory syndrome coronavirus main protease.
Reaction catalysed
TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position
  • SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing.
  • Belongs to peptidase family C30.
PRIAM enzyme-specific profiles3.4.22.69
KEGG Ligand Database for Enzyme Nomenclature3.4.22.69
IUBMB Enzyme Nomenclature3.4.22.69
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.22.69
P0C6X7, R1AB_SARS;  P0DTD1, R1AB_SARS2;  P0C6F7, R1A_BC133;  
P0C6F5, R1A_BC279;  P0C6F8, R1A_BCHK3;  P0C6T4, R1A_BCHK4;  
P0C6T5, R1A_BCHK5;  P0C6T6, R1A_BCHK9;  P0C6T7, R1A_BCRP3;  
P0C6T8, R1A_CVBEN;  P0C6T9, R1A_CVBLU;  P0C6U0, R1A_CVBM;  
P0C6U1, R1A_CVBQ;  P0C6U3, R1A_CVHN1;  P0C6U4, R1A_CVHN2;  
P0C6U5, R1A_CVHN5;  P0C6U7, R1A_CVHOC;  P0C6U9, R1A_CVM2;  
P0C6V0, R1A_CVMA5;  P0C6V1, R1A_CVMJH;  K9N638, R1A_MERS1;  
P0C6U8, R1A_SARS;  P0DTC1, R1A_SARS2;  

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