ENZYME entry: EC 3.4.22.69
| Accepted Name |
|---|
| SARS coronavirus main proteinase.
|
| Alternative Name(s) |
|---|
| 3C-like protease. |
| 3cLpro. |
| Coronavirus 3C-like protease. |
| SARS coronavirus main protease. |
| SARS-CoV 3CLpro enzyme. |
| Severe acute respiratory syndrome coronavirus main protease. |
| Reaction catalysed |
|---|
| TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position |
| Comment(s) |
|---|
- SARS coronavirus main protease is the key enzyme in SARS coronavirus
replicase polyprotein processing.
- Belongs to peptidase family C30.
|
| Cross-references |
|---|
| BRENDA | 3.4.22.69 |
| EC2PDB | 3.4.22.69 |
| ExplorEnz | 3.4.22.69 |
| PRIAM enzyme-specific profiles | 3.4.22.69 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.69 |
| IUBMB Enzyme Nomenclature | 3.4.22.69 |
| IntEnz | 3.4.22.69 |
| MEDLINE | Find literature relating to 3.4.22.69 |
| MetaCyc | 3.4.22.69 |
| Rhea expert-curated reactions | 3.4.22.69 |
| UniProtKB/Swiss-Prot |
| P0C6X7, R1AB_SARS; | P0DTD1, R1AB_SARS2; | P0C6F7, R1A_BC133; |
| P0C6F5, R1A_BC279; | P0C6F8, R1A_BCHK3; | P0C6T4, R1A_BCHK4; |
| P0C6T5, R1A_BCHK5; | P0C6T6, R1A_BCHK9; | P0C6T7, R1A_BCRP3; |
| P0C6T8, R1A_CVBEN; | P0C6T9, R1A_CVBLU; | P0C6U0, R1A_CVBM; |
| P0C6U1, R1A_CVBQ; | P0C6U3, R1A_CVHN1; | P0C6U4, R1A_CVHN2; |
| P0C6U5, R1A_CVHN5; | P0C6U7, R1A_CVHOC; | P0C6U9, R1A_CVM2; |
| P0C6V0, R1A_CVMA5; | P0C6V1, R1A_CVMJH; | K9N638, R1A_MERS1; |
| P0C6U8, R1A_SARS; | P0DTC1, R1A_SARS2; |
|
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