ENZYME entry: EC 3.4.22.69
Accepted Name |
SARS coronavirus main proteinase.
|
Alternative Name(s) |
3C-like protease. |
3cLpro. |
Coronavirus 3C-like protease. |
SARS coronavirus main protease. |
SARS-CoV 3CLpro enzyme. |
Severe acute respiratory syndrome coronavirus main protease. |
Reaction catalysed |
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position |
Comment(s) |
- SARS coronavirus main protease is the key enzyme in SARS coronavirus
replicase polyprotein processing.
- Belongs to peptidase family C30.
|
Cross-references |
BRENDA | 3.4.22.69 |
EC2PDB | 3.4.22.69 |
ExplorEnz | 3.4.22.69 |
PRIAM enzyme-specific profiles | 3.4.22.69 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.69 |
IUBMB Enzyme Nomenclature | 3.4.22.69 |
IntEnz | 3.4.22.69 |
MEDLINE | Find literature relating to 3.4.22.69 |
MetaCyc | 3.4.22.69 |
Rhea expert-curated reactions | 3.4.22.69 |
UniProtKB/Swiss-Prot |
P0C6X7, R1AB_SARS; | P0DTD1, R1AB_SARS2; | P0C6F7, R1A_BC133; |
P0C6F5, R1A_BC279; | P0C6F8, R1A_BCHK3; | P0C6T4, R1A_BCHK4; |
P0C6T5, R1A_BCHK5; | P0C6T6, R1A_BCHK9; | P0C6T7, R1A_BCRP3; |
P0C6T8, R1A_CVBEN; | P0C6T9, R1A_CVBLU; | P0C6U0, R1A_CVBM; |
P0C6U1, R1A_CVBQ; | P0C6U3, R1A_CVHN1; | P0C6U4, R1A_CVHN2; |
P0C6U5, R1A_CVHN5; | P0C6U7, R1A_CVHOC; | P0C6U9, R1A_CVM2; |
P0C6V0, R1A_CVMA5; | P0C6V1, R1A_CVMJH; | K9N638, R1A_MERS1; |
P0C6U8, R1A_SARS; | P0DTC1, R1A_SARS2; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-