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ENZYME

ENZYME entry: EC 3.4.23.1

PURL: https://purl.expasy.org/enzyme/EC/3.4.23.1
Accepted Name
pepsin A
Alternative Name(s)
pepsin
Reaction catalysed
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin
Comment(s)
  • The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.1.
Cross-references
BRENDA3.4.23.1
EC2PDB3.4.23.1
ExplorEnz3.4.23.1
KEGG Ligand Database for Enzyme Nomenclature3.4.23.1
IUBMB Enzyme Nomenclature3.4.23.1
MEDLINEFind literature relating to 3.4.23.1
MetaCyc3.4.23.1
Rhea expert-curated reactions3.4.23.1
UniProtKB/Swiss-Prot
P03954, PEPA1_MACFUP28712, PEPA1_RABITP27677, PEPA2_MACFU
P27821, PEPA2_RABITP0DJD8, PEPA3_HUMANP27822, PEPA3_RABIT
P0DJD7, PEPA4_HUMANP27678, PEPA4_MACFUP28713, PEPA4_RABIT
P0DJD9, PEPA5_HUMANQ9D106, PEPA5_MOUSEP27823, PEPAF_RABIT
P00792, PEPA_BOVINQ9N2D4, PEPA_CALJAQ9GMY6, PEPA_CANLF
P00793, PEPA_CHICKP11489, PEPA_MACMUP00791, PEPA_PIG
Q9GMY7, PEPA_RHIFEQ9GMY8, PEPA_SORUNP81497, PEPA_SUNMU
P13636, PEPA_URSTH

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