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ENZYME entry: EC 3.4.23.41

Accepted Name
Yapsin 1.
Alternative Name(s)
Aspartic proteinase 3.
Yeast aspartic protease 3.
Reaction catalysed
Hydrolyzes various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favorable in both non-prime and prime positions
Comment(s)
  • Weakly inhibited by pepstatin.
  • Can partially substitute for kexin in a deficient strain of Saccharomyces cerevisiae.
  • The homologous product of the MKC7 gene (S.cerevisiae) has similar catalytic activity and has been termed yapsin 2.
  • Belongs to peptidase family A1.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.41
EC2PDB3.4.23.41
ExplorEnz3.4.23.41
PRIAM enzyme-specific profiles3.4.23.41
KEGG Ligand Database for Enzyme Nomenclature3.4.23.41
IUBMB Enzyme Nomenclature3.4.23.41
IntEnz3.4.23.41
MEDLINEFind literature relating to 3.4.23.41
MetaCyc3.4.23.41
UniProtKB/Swiss-Prot
P53379, MKC7_YEAST;  P32329, YPS1_YEAST;  

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