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ENZYME

ENZYME entry: EC 3.4.23.41

PURL: https://purl.expasy.org/enzyme/EC/3.4.23.41
Accepted Name
yapsin 1
Alternative Name(s)
aspartic proteinase 3
yeast aspartic protease 3
Reaction catalysed
Hydrolyzes various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favorable in both non-prime and prime positions
Comment(s)
  • Weakly inhibited by pepstatin.
  • Can partially substitute for kexin in a deficient strain of Saccharomyces cerevisiae.
  • The homologous product of the MKC7 gene (S.cerevisiae) has similar catalytic activity and has been termed yapsin 2.
  • Belongs to peptidase family A1.
Cross-references
BRENDA3.4.23.41
EC2PDB3.4.23.41
ExplorEnz3.4.23.41
KEGG Ligand Database for Enzyme Nomenclature3.4.23.41
IUBMB Enzyme Nomenclature3.4.23.41
MEDLINEFind literature relating to 3.4.23.41
MetaCyc3.4.23.41
Rhea expert-curated reactions3.4.23.41
UniProtKB/Swiss-Prot
P53379, MKC7_YEASTP32329, YPS1_YEAST

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