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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.23.46

Accepted Name
Memapsin 2.
Alternative Name(s)
BACE1.
Beta-secretase.
Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1.
Beta-site APP-cleaving enzyme 1.
Membrane-associated aspartic protease 2.
Reaction catalysed
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment(s)
  • Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease.
  • Belongs to peptidase family A1.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.46
EC2PDB3.4.23.46
ExplorEnz3.4.23.46
PRIAM enzyme-specific profiles3.4.23.46
KEGG Ligand Database for Enzyme Nomenclature3.4.23.46
IUBMB Enzyme Nomenclature3.4.23.46
IntEnz3.4.23.46
MEDLINEFind literature relating to 3.4.23.46
MetaCyc3.4.23.46
UniProtKB/Swiss-Prot
Q2HJ40, BACE1_BOVIN;  Q1KLR6, BACE1_CAVPO;  P56817, BACE1_HUMAN;  
P56818, BACE1_MOUSE;  P56819, BACE1_RAT;  

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