ENZYME entry: EC 3.4.23.46
Accepted Name |
memapsin 2.
|
Alternative Name(s) |
BACE1. |
beta-secretase. |
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1. |
beta-site APP-cleaving enzyme 1. |
membrane-associated aspartic protease 2. |
Reaction catalysed |
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
Comment(s) |
- Suggested to be the major 'beta-secretase' responsible for the
cleavage of the beta-amyloid precursor protein to form the
amyloidogenic beta-peptide that is implicated in the pathology of
Alzheimer's disease.
- Belongs to peptidase family A1.
|
Cross-references |
BRENDA | 3.4.23.46 |
EC2PDB | 3.4.23.46 |
ExplorEnz | 3.4.23.46 |
PRIAM enzyme-specific profiles | 3.4.23.46 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.46 |
IUBMB Enzyme Nomenclature | 3.4.23.46 |
IntEnz | 3.4.23.46 |
MEDLINE | Find literature relating to 3.4.23.46 |
MetaCyc | 3.4.23.46 |
Rhea expert-curated reactions | 3.4.23.46 |
UniProtKB/Swiss-Prot |
|
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