A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.23.46
| Accepted Name |
|---|
| Memapsin 2.
|
| Alternative Name(s) |
|---|
| BACE1. |
| Beta-secretase. |
| Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1. |
| Beta-site APP-cleaving enzyme 1. |
| Membrane-associated aspartic protease 2. |
| Reaction catalysed |
|---|
| Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
| Comment(s) |
|---|
- Suggested to be the major 'beta-secretase' responsible for the
cleavage of the beta-amyloid precursor protein to form the
amyloidogenic beta-peptide that is implicated in the pathology of
Alzheimer's disease.
- Belongs to peptidase family A1.
|
| Cross-references |
|---|
| PROSITE | PDOC00128 |
| BRENDA | 3.4.23.46 |
| EC2PDB | 3.4.23.46 |
| ExplorEnz | 3.4.23.46 |
| PRIAM enzyme-specific profiles | 3.4.23.46 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.46 |
| IUBMB Enzyme Nomenclature | 3.4.23.46 |
| IntEnz | 3.4.23.46 |
| MEDLINE | Find literature relating to 3.4.23.46 |
| MetaCyc | 3.4.23.46 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-