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ENZYME

ENZYME entry: EC 3.4.23.46

PURL: https://purl.expasy.org/enzyme/EC/3.4.23.46
Accepted Name
memapsin 2
Alternative Name(s)
BACE1
beta-secretase
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1
beta-site APP-cleaving enzyme 1
membrane-associated aspartic protease 2
Reaction catalysed
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment(s)
  • Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease.
  • Belongs to peptidase family A1.
Cross-references
BRENDA3.4.23.46
EC2PDB3.4.23.46
ExplorEnz3.4.23.46
KEGG Ligand Database for Enzyme Nomenclature3.4.23.46
IUBMB Enzyme Nomenclature3.4.23.46
MEDLINEFind literature relating to 3.4.23.46
MetaCyc3.4.23.46
Rhea expert-curated reactions3.4.23.46
UniProtKB/Swiss-Prot
Q2HJ40, BACE1_BOVINQ1KLR6, BACE1_CAVPOP56817, BACE1_HUMAN
P56818, BACE1_MOUSEP56819, BACE1_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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