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ENZYME

ENZYME entry: EC 3.4.24.11

Accepted Name
neprilysin
Alternative Name(s)
endopeptidase-2
enkephalinase
kidney-brush-border neutral proteinase
membrane metalloendopeptidase
neutral endopeptidase
Reaction catalysed
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Comment(s)
  • A membrane-bound glycoprotein widely distributed in animal tissues.
  • Inhibited by phosphoramidon and thiorphan.
  • Belongs to peptidase family M13.
Cross-references
BRENDA3.4.24.11
EC2PDB3.4.24.11
ExplorEnz3.4.24.11
PRIAM enzyme-specific profiles3.4.24.11
KEGG Ligand Database for Enzyme Nomenclature3.4.24.11
IUBMB Enzyme Nomenclature3.4.24.11
IntEnz3.4.24.11
MEDLINEFind literature relating to 3.4.24.11
MetaCyc3.4.24.11
Rhea expert-curated reactions3.4.24.11
UniProtKB/Swiss-Prot
Q495T6, MMEL1_HUMANQ9JLI3, MMEL1_MOUSEP0C1T0, MMEL1_RAT
A0A0B4K692, NEP2_DROMEQ9W5Y0, NEP3_DROMEQ8T062, NEP4_DROME
Q9W436, NEP_DROMEP08473, NEP_HUMANQ61391, NEP_MOUSE
P19621, NEP_PIGQ5RE69, NEP_PONABP08049, NEP_RABIT
P07861, NEP_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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