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ENZYME entry: EC 3.4.24.56

Accepted Name
Insulysin.
Alternative Name(s)
Insulin protease.
Insulin-degrading enzyme.
Insulinase.
Reaction catalysed
Degradation of insulin, glucagon and other polypeptides. No action on proteins
Cofactor(s)
Zn(2+).
Comment(s)
  • Cytosolic enzyme, known from mammals and Drosophila melanogaster.
  • Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon.
  • Belongs to peptidase family M16.
  • Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.
Cross-references
PROSITEPDOC00130
BRENDA3.4.24.56
EC2PDB3.4.24.56
ExplorEnz3.4.24.56
PRIAM enzyme-specific profiles3.4.24.56
KEGG Ligand Database for Enzyme Nomenclature3.4.24.56
IUBMB Enzyme Nomenclature3.4.24.56
IntEnz3.4.24.56
MEDLINEFind literature relating to 3.4.24.56
MetaCyc3.4.24.56
Rhea expert-curated reactions3.4.24.56
UniProtKB/Swiss-Prot
Q24K02, IDE_BOVIN;  P22817, IDE_DROME;  P14735, IDE_HUMAN;  
Q9JHR7, IDE_MOUSE;  P35559, IDE_RAT;  

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