ENZYME entry: EC 3.4.24.56
Accepted Name |
Insulysin.
|
Alternative Name(s) |
Insulin protease. |
Insulin-degrading enzyme. |
Insulinase. |
Reaction catalysed |
Degradation of insulin, glucagon and other polypeptides. No action on proteins |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Cytosolic enzyme, known from mammals and Drosophila melanogaster.
- Inhibited by bacitracin, chelating agents EDTA and 1,10-
phenanthroline, and by thiol-blocking reagents such as
N-ethylmaleimide, but not by phosphoramidon.
- Belongs to peptidase family M16.
- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.
|
Cross-references |
PROSITE | PDOC00130 |
BRENDA | 3.4.24.56 |
EC2PDB | 3.4.24.56 |
ExplorEnz | 3.4.24.56 |
PRIAM enzyme-specific profiles | 3.4.24.56 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.56 |
IUBMB Enzyme Nomenclature | 3.4.24.56 |
IntEnz | 3.4.24.56 |
MEDLINE | Find literature relating to 3.4.24.56 |
MetaCyc | 3.4.24.56 |
Rhea expert-curated reactions | 3.4.24.56 |
UniProtKB/Swiss-Prot |
|
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