ENZYME entry: EC 3.4.24.60
| Accepted Name |
|---|
| Dactylysin.
|
| Alternative Name(s) |
|---|
| Peptide hormone inactivating endopeptidase. |
| Reaction catalysed |
|---|
| Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-|-Phe- and -Phe-|-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively |
| Comment(s) |
|---|
- An endopeptidase of 100 kDa secreted from the skin of Xenopus laevis.
- Resembles neprilysin in insensitivity to 1 uM captopril, but differs
in being insensitive to thiorphan and unable to digest (5-Met)-
enkephalin, (5-Leu)-enkephalin, oxytocin and substance P-(7-11)-
peptide.
|
| Cross-references |
|---|
| BRENDA | 3.4.24.60 |
| EC2PDB | 3.4.24.60 |
| ExplorEnz | 3.4.24.60 |
| PRIAM enzyme-specific profiles | 3.4.24.60 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.60 |
| IUBMB Enzyme Nomenclature | 3.4.24.60 |
| IntEnz | 3.4.24.60 |
| MEDLINE | Find literature relating to 3.4.24.60 |
| MetaCyc | 3.4.24.60 |
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