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ENZYME entry: EC

Accepted Name
interstitial collagenase.
Alternative Name(s)
matrix metalloproteinase 1.
vertebrate collagenase.
Reaction catalysed
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
  • The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain.
  • alpha-macroglobulins are cleaved much more rapidly.
  • The enzyme is widely distributed in vertebrate animals.
  • Belongs to peptidase family M10B.
PRIAM enzyme-specific profiles3.4.24.7
KEGG Ligand Database for Enzyme Nomenclature3.4.24.7
IUBMB Enzyme Nomenclature3.4.24.7
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.24.7
P28053, MMP1_BOVIN;  Q9XSZ5, MMP1_HORSE;  P03956, MMP1_HUMAN;  
Q11133, MMP1_LITCT;  P21692, MMP1_PIG;  P13943, MMP1_RABIT;  
P81563, MMP1_RAT;  

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