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ENZYME entry: EC 3.4.24.81

Accepted Name
ADAM10 endopeptidase.
Alternative Name(s)
Kuzbanian protein.
Myelin-associated disintegrin metalloproteinase.
Reaction catalysed
Endopeptidase of broad specificity
Cofactor(s)
Zn(2+).
Comment(s)
  • Partially responsible for the 'alpha-secretase' activity in brain that degrades the potentially harmful beta-amyloid peptide.
  • Work with ADAM10-deficient mice supports a role in Notch signaling.
  • Belongs to peptidase family M12.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.81
EC2PDB3.4.24.81
ExplorEnz3.4.24.81
PRIAM enzyme-specific profiles3.4.24.81
KEGG Ligand Database for Enzyme Nomenclature3.4.24.81
IUBMB Enzyme Nomenclature3.4.24.81
IntEnz3.4.24.81
MEDLINEFind literature relating to 3.4.24.81
MetaCyc3.4.24.81
Rhea expert-curated reactions3.4.24.81
UniProtKB/Swiss-Prot
Q10741, ADA10_BOVIN;  G5EFD9, ADA10_CAEEL;  O14672, ADA10_HUMAN;  
O35598, ADA10_MOUSE;  O77633, ADA10_PIG;  Q10743, ADA10_RAT;  
Q8JIY1, ADA10_XENLA;  

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