ENZYME entry: EC 3.4.24.82
Accepted Name |
ADAMTS-4 endopeptidase.
|
Alternative Name(s) |
Aggrecanase-1. |
Reaction catalysed |
Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Thought to be biologically significant for the degradation of the
aggrecan component of cartilage matrix.
- Belongs to peptidase family M12.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.82 |
EC2PDB | 3.4.24.82 |
ExplorEnz | 3.4.24.82 |
PRIAM enzyme-specific profiles | 3.4.24.82 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.82 |
IUBMB Enzyme Nomenclature | 3.4.24.82 |
IntEnz | 3.4.24.82 |
MEDLINE | Find literature relating to 3.4.24.82 |
MetaCyc | 3.4.24.82 |
Rhea expert-curated reactions | 3.4.24.82 |
UniProtKB/Swiss-Prot |
|
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