ENZYME entry: EC 3.4.24.86
| Accepted Name | |||||
|---|---|---|---|---|---|
| ADAM 17 endopeptidase | |||||
| Alternative Name(s) | |||||
| TACE | |||||
| tumor necrosis factor alpha-converting enzyme | |||||
| Reaction catalysed | |||||
| Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains | |||||
| Comment(s) | |||||
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| Cross-references | |||||
| BRENDA | 3.4.24.86 | ||||
| EC2PDB | 3.4.24.86 | ||||
| ExplorEnz | 3.4.24.86 | ||||
| PRIAM enzyme-specific profiles | 3.4.24.86 | ||||
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.86 | ||||
| IUBMB Enzyme Nomenclature | 3.4.24.86 | ||||
| IntEnz | 3.4.24.86 | ||||
| MEDLINE | Find literature relating to 3.4.24.86 | ||||
| MetaCyc | 3.4.24.86 | ||||
| Rhea expert-curated reactions | 3.4.24.86 | ||||
| UniProtKB/Swiss-Prot |
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