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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Protein N-terminal asparagine amidohydrolase.
Reaction catalysed
N-terminal L-asparaginyl-[protein] + H(2)O <=> N-terminal L-aspartyl-[protein] + NH(3)
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate.
  • The latter serves as a substrate for EC making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
PRIAM enzyme-specific profiles3.5.1.121
KEGG Ligand Database for Enzyme Nomenclature3.5.1.121
IUBMB Enzyme Nomenclature3.5.1.121
MEDLINEFind literature relating to
O64876, NTAN1_ARATH;  Q96AB6, NTAN1_HUMAN;  Q64311, NTAN1_MOUSE;  
Q28955, NTAN1_PIG;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-