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ENZYME entry: EC 3.5.1.121

Accepted Name
Protein N-terminal asparagine amidohydrolase.
Reaction catalysed
N-terminal L-asparaginyl-[protein] + H(2)O <=> N-terminal L-aspartyl-[protein] + NH(3)
Comment(s)
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate.
  • The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
Cross-references
BRENDA3.5.1.121
EC2PDB3.5.1.121
ExplorEnz3.5.1.121
PRIAM enzyme-specific profiles3.5.1.121
KEGG Ligand Database for Enzyme Nomenclature3.5.1.121
IUBMB Enzyme Nomenclature3.5.1.121
IntEnz3.5.1.121
MEDLINEFind literature relating to 3.5.1.121
MetaCyc3.5.1.121
UniProtKB/Swiss-Prot
O64876, NTAN1_ARATH;  Q96AB6, NTAN1_HUMAN;  Q64311, NTAN1_MOUSE;  
Q28955, NTAN1_PIG;  

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