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ENZYME entry: EC 3.5.1.133

Accepted Name
N(alpha)-acyl-L-glutamine aminoacylase.
Alternative Name(s)
AMRE.
Axillary malodor releasing enzyme.
Reaction catalysed
An N(alpha)-acyl-L-glutamine + H(2)O <=> L-glutamine + a carboxylate
Comment(s)
  • Requires Zn(2+).
  • The enzyme, characterized from the bacterium Corynebacterium sp.Ax20, hydrolyzes odorless N(alpha)-acyl-L-glutamine conjugates of short- and medium-chain fatty acids, releasing axillary malodor compounds.
  • While the enzyme is highly specific for the L-glutamine moiety, it is quite promiscuous regarding the acyl moiety.
  • The two most common products of the enzyme's activity in axillary secretions are (2E)-3-methylhex-2-enoate and 3-hydroxy-3- methylhexanoate.
Cross-references
BRENDA3.5.1.133
EC2PDB3.5.1.133
ExplorEnz3.5.1.133
PRIAM enzyme-specific profiles3.5.1.133
KEGG Ligand Database for Enzyme Nomenclature3.5.1.133
IUBMB Enzyme Nomenclature3.5.1.133
IntEnz3.5.1.133
MEDLINEFind literature relating to 3.5.1.133
MetaCyc3.5.1.133
Rhea expert-curated reactions3.5.1.133
UniProtKB/Swiss-Prot
Q8GGD4, AGAA_CORST

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