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ENZYME

ENZYME entry: EC 3.5.1.137

Accepted Name
N-methylcarbamate hydrolase
Alternative Name(s)
carbaryl hydrolase
carbofuran hydrolase
Reaction catalysed
an N-methyl carbamate ester + H(+) + H2O <=> an alcohol + CO2 + methylamine
Comment(s)
  • The enzyme catalyzes the first step in the degradation of several carbamate insecticides such as carbaryl, carbofuran, isoprocarb, propoxur, aldicarb and oxamyl.
  • It catalyzes the cleavage of the ester bond to release N-methylcarbamate, which spontaneously hydrolyzes to methylamine and CO2.
  • The enzymes from several Gram-negative bacteria were shown to be located in the periplasm.
Cross-references
BRENDA3.5.1.137
EC2PDB3.5.1.137
ExplorEnz3.5.1.137
PRIAM enzyme-specific profiles3.5.1.137
KEGG Ligand Database for Enzyme Nomenclature3.5.1.137
IUBMB Enzyme Nomenclature3.5.1.137
IntEnz3.5.1.137
MEDLINEFind literature relating to 3.5.1.137
MetaCyc3.5.1.137
Rhea expert-curated reactions3.5.1.137

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-