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ENZYME

ENZYME entry: EC 3.5.1.46

Accepted Name
6-aminohexanoate-oligomer exohydrolase
Alternative Name(s)
6-aminohexanoate-dimer hydrolase
6-aminohexanoic acid oligomer hydrolase
nylon-6 hydrolase
Reaction catalysed
  • [N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)
  • H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate
Comment(s)
  • The enzyme is involved in degradation of nylon-6 oligomers.
  • It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus.
  • Activity decreases with the increase of the polymerization number of the oligomer; cf. EC 3.5.1.117 and EC 3.5.2.12.
Cross-references
BRENDA3.5.1.46
EC2PDB3.5.1.46
ExplorEnz3.5.1.46
PRIAM enzyme-specific profiles3.5.1.46
KEGG Ligand Database for Enzyme Nomenclature3.5.1.46
IUBMB Enzyme Nomenclature3.5.1.46
IntEnz3.5.1.46
MEDLINEFind literature relating to 3.5.1.46
MetaCyc3.5.1.46
Rhea expert-curated reactions3.5.1.46
UniProtKB/Swiss-Prot
P07062, NYLB2_FLASKP07061, NYLB_FLASK

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