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ENZYME entry: EC 3.5.1.46

Accepted Name
6-aminohexanoate-oligomer exohydrolase.
Alternative Name(s)
6-aminohexanoate-dimer hydrolase.
6-aminohexanoic acid oligomer hydrolase.
Nylon-6 hydrolase.
Reaction catalysed
  • (N-(6-aminohexanoyl))(n) + H(2)O <=> (N-(6-aminohexanoyl))(n-1) + 6-aminohexanoate
  • N-(6-aminohexanoyl)-6-aminohexanoate + H(2)O <=> 2 6-aminohexanoate
Comment(s)
  • The enzyme is involved in degradation of nylon-6 oligomers.
  • It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus.
  • Activity decreases with the increase of the polymerization number of the oligomer; cf. EC 3.5.1.117 and EC 3.5.2.12.
Cross-references
BRENDA3.5.1.46
EC2PDB3.5.1.46
ExplorEnz3.5.1.46
PRIAM enzyme-specific profiles3.5.1.46
KEGG Ligand Database for Enzyme Nomenclature3.5.1.46
IUBMB Enzyme Nomenclature3.5.1.46
IntEnz3.5.1.46
MEDLINEFind literature relating to 3.5.1.46
MetaCyc3.5.1.46
Rhea expert-curated reactions3.5.1.46
UniProtKB/Swiss-Prot
P07062, NYLB2_FLASK;  P07061, NYLB_FLASK;  

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