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ENZYME entry: EC

Accepted Name
Allophanate hydrolase.
Reaction catalysed
Urea-1-carboxylate + H(2)O <=> 2 CO(2) + 2 NH(3)
  • Along with EC and EC, forms part of the cyanuric- acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5- triazine), in bacteria.
  • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC, thus bringing about the hydrolysis of urea to CO(2) and NH(3) in the presence of ATP and bicarbonate.
  • The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate.
PRIAM enzyme-specific profiles3.5.1.54
KEGG Ligand Database for Enzyme Nomenclature3.5.1.54
IUBMB Enzyme Nomenclature3.5.1.54
MEDLINEFind literature relating to
Rhea expert-curated reactions3.5.1.54
Q936X2, ATZF_PSESD;  A5H0J2, DUR1_LACKL;  P32528, DUR1_YEAST;  

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