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ENZYME

ENZYME entry: EC 3.5.1.54

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.54
Accepted Name
allophanate hydrolase
Reaction catalysed
urea-1-carboxylate + H2O + 3 H(+) = 2 NH4(+) + 2 CO2
Comment(s)
  • Along with EC 3.5.2.15 and EC 3.5.1.84, forms part of the cyanuric- acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5- triazine], in bacteria.
  • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 6.3.4.6, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate.
  • The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate.
Cross-references
BRENDA3.5.1.54
EC2PDB3.5.1.54
ExplorEnz3.5.1.54
KEGG Ligand Database for Enzyme Nomenclature3.5.1.54
IUBMB Enzyme Nomenclature3.5.1.54
MEDLINEFind literature relating to 3.5.1.54
MetaCyc3.5.1.54
Rhea expert-curated reactions3.5.1.54
UniProtKB/Swiss-Prot
Q936X2, ATZF_PSESDA5H0J2, DUR1_LACKLP32528, DUR1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-