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ENZYME

ENZYME entry: EC 6.3.4.6

Accepted Name
urea carboxylase
Alternative Name(s)
ATP--urea amidolyase
UALase
UCA
urea amidolyase
urea carboxylase (hydrolyzing)
urease (ATP-hydrolyzing)
Reaction catalysed
ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate
Comment(s)
  • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 3.5.1.54, thus bringing about the hydrolysis of urea to CO2 and NH3.
  • The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates.
  • Formerly EC 3.5.1.45.
Cross-references
BRENDA6.3.4.6
EC2PDB6.3.4.6
ExplorEnz6.3.4.6
PRIAM enzyme-specific profiles6.3.4.6
KEGG Ligand Database for Enzyme Nomenclature6.3.4.6
IUBMB Enzyme Nomenclature6.3.4.6
IntEnz6.3.4.6
MEDLINEFind literature relating to 6.3.4.6
MetaCyc6.3.4.6
Rhea expert-curated reactions6.3.4.6
UniProtKB/Swiss-Prot
A5H0J2, DUR1_LACKLP32528, DUR1_YEASTP38095, LAMA_EMENI

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