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ENZYME

ENZYME entry: EC 3.5.4.16

PURL: https://purl.expasy.org/enzyme/EC/3.5.4.16
Accepted Name
GTP cyclohydrolase I
Reaction catalysed
GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
Comment(s)
  • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
Cross-references
BRENDA3.5.4.16
EC2PDB3.5.4.16
ExplorEnz3.5.4.16
KEGG Ligand Database for Enzyme Nomenclature3.5.4.16
IUBMB Enzyme Nomenclature3.5.4.16
MEDLINEFind literature relating to 3.5.4.16
MetaCyc3.5.4.16
Rhea expert-curated reactions3.5.4.16
UniProtKB/Swiss-Prot
Q9CGE3, FOLKE_LACLAQ8GJP4, FOLKE_LACLMQ8YLL1, GCH11_NOSS1
Q9HYG8, GCH11_PSEAEQ88LV4, GCH11_PSEPKQ887V1, GCH11_PSESM
Q8YN49, GCH12_NOSS1Q9I351, GCH12_PSEAEQ88JY1, GCH12_PSEPK
Q884Q3, GCH12_PSESMA3DHH6, GCH1_ACET2A3N0R3, GCH1_ACTP2
B3GXP9, GCH1_ACTP7B0BPI8, GCH1_ACTPJA0KIN6, GCH1_AERHH
A4SPE8, GCH1_AERS4Q8UEK8, GCH1_AGRFCQ5E4E4, GCH1_ALIF1
B5FF36, GCH1_ALIFMB6EGN8, GCH1_ALISLQ0A939, GCH1_ALKEH
B9JWF1, GCH1_ALLAMO66603, GCH1_AQUAEQ9SFV7, GCH1_ARATH
A8HUG2, GCH1_AZOC5C1DHG2, GCH1_AZOVDC3P598, GCH1_BACAA
C3L8S8, GCH1_BACACA0RBW5, GCH1_BACAHQ81SW2, GCH1_BACAN
B7JGZ6, GCH1_BACC0Q73AY4, GCH1_BACC1B7IP89, GCH1_BACC2
C1EN08, GCH1_BACC3B7HHR5, GCH1_BACC4B7HL21, GCH1_BACC7
A7GN48, GCH1_BACCNB9IVN3, GCH1_BACCQQ81FQ8, GCH1_BACCR
Q63DM1, GCH1_BACCZQ5L925, GCH1_BACFNQ64P85, GCH1_BACFR
Q6HL44, GCH1_BACHKA9VMC0, GCH1_BACMKA8FEL2, GCH1_BACP2
P48063, GCH1_BACPUP19465, GCH1_BACSUQ8A0U0, GCH1_BACTN
A7Z630, GCH1_BACVZA1USJ5, GCH1_BARBKQ6G3J8, GCH1_BARHE
Q6FZZ4, GCH1_BARQUQ1LT77, GCH1_BAUCHB2IBC4, GCH1_BEII9
B3DR12, GCH1_BIFLDQ8G3S1, GCH1_BIFLOQ7VRX3, GCH1_BLOFL
Q492J7, GCH1_BLOPBQ89IW2, GCH1_BRADUC0ZCC7, GCH1_BREBN
B2S5T0, GCH1_BRUA1Q2YQ03, GCH1_BRUA2A6X0X0, GCH1_BRUA4
Q57D61, GCH1_BRUABA9M586, GCH1_BRUC2C0RJ47, GCH1_BRUMB
Q8YH94, GCH1_BRUMEA5VQL0, GCH1_BRUO2B0CGM4, GCH1_BRUSI
Q8G0L4, GCH1_BRUSUQ8KA05, GCH1_BUCAPQ19980, GCH1_CAEEL
A8MC60, GCH1_CALMQQ8R7N2, GCH1_CALS4A7ZB36, GCH1_CAMC1
A7GW42, GCH1_CAMC5A8FJZ5, GCH1_CAMJ8A7H1R1, GCH1_CAMJD
P51594, GCH1_CAMJEA1VXS2, GCH1_CAMJJQ5HWX4, GCH1_CAMJR
B9KDZ8, GCH1_CAMLRQ3ADI2, GCH1_CARHZQ9AAY3, GCH1_CAUVC
Q11JM4, GCH1_CHESBP50141, GCH1_CHICKQ3ATN0, GCH1_CHLCH
A4SF37, GCH1_CHLPMQ8KEA8, GCH1_CHLTEQ1QV64, GCH1_CHRSD
Q7NYZ2, GCH1_CHRVOA8AE79, GCH1_CITK8Q97D54, GCH1_CLOAB
A7FU67, GCH1_CLOB1C3KVW3, GCH1_CLOB6A6LWG6, GCH1_CLOB8
A5I231, GCH1_CLOBHC1FN26, GCH1_CLOBJB1IL94, GCH1_CLOBK
A7GDP1, GCH1_CLOBLB1L1S1, GCH1_CLOBMQ18BW7, GCH1_CLOD6
B9E092, GCH1_CLOK1A5N6S3, GCH1_CLOK5A0Q2L7, GCH1_CLONN
Q0TRM0, GCH1_CLOP1Q8XLM2, GCH1_CLOPEQ0STY9, GCH1_CLOPS
C3PJE8, GCH1_CORA7Q8FMG3, GCH1_COREFA4QH94, GCH1_CORGB
Q8NM84, GCH1_CORGLA9KFF3, GCH1_COXBNA9NDB3, GCH1_COXBR
Q83DE3, GCH1_COXBUQ3Z782, GCH1_DEHM1A5FQD3, GCH1_DEHMB
Q3ZYB5, GCH1_DEHMCQ9RYB4, GCH1_DEIRAA4J5D0, GCH1_DESRM
Q94465, GCH1_DICDIP48596, GCH1_DROMEA7ZNX6, GCH1_ECO24
B7UFG9, GCH1_ECO27B7MF66, GCH1_ECO45B7LAH4, GCH1_ECO55
P0A6T7, GCH1_ECO57B5YWU3, GCH1_ECO5EB7NMB8, GCH1_ECO7I
B7MXG6, GCH1_ECO81B7M4Z9, GCH1_ECO8AC4ZU03, GCH1_ECOBW
B1X7P1, GCH1_ECODHA8A214, GCH1_ECOHSA1AD13, GCH1_ECOK1
Q0TFT7, GCH1_ECOL5P0A6T6, GCH1_ECOL6B1IYB6, GCH1_ECOLC
P0A6T5, GCH1_ECOLIB7NCI3, GCH1_ECOLUB6I8K3, GCH1_ECOSE
B1LKQ0, GCH1_ECOSMQ1R9R9, GCH1_ECOUTC5BCL9, GCH1_EDWI9
A4WCI8, GCH1_ENT38Q82Z12, GCH1_ENTFAB2VII2, GCH1_ERWT9
B7LVB3, GCH1_ESCF3P51597, GCH1_EUGGRB0S1R1, GCH1_FINM2
A5FHM7, GCH1_FLAJ1Q8RH43, GCH1_FUSNNQ5KXT7, GCH1_GEOKA
C5D3E8, GCH1_GEOSWQ7NK98, GCH1_GLOVIQ7VM90, GCH1_HAEDU
Q4QKH4, GCH1_HAEI8A5UC59, GCH1_HAEIEA5UEW4, GCH1_HAEIG
P43866, GCH1_HAEINQ2SPJ2, GCH1_HAHCHQ9KCC7, GCH1_HALH5
C4K3L4, GCH1_HAMD5Q17WX5, GCH1_HELAHQ7VFG4, GCH1_HELHP
B6JME9, GCH1_HELP2B5Z7T2, GCH1_HELPGQ1CSU6, GCH1_HELPH
Q9ZKS2, GCH1_HELPJB2UU76, GCH1_HELPSP56462, GCH1_HELPY
Q0I3F6, GCH1_HISS1B0UUA9, GCH1_HISS2P30793, GCH1_HUMAN
B4U640, GCH1_HYDS0A2BL58, GCH1_HYPBUQ0BXB5, GCH1_HYPNA
A6SZ52, GCH1_JANMAB5XP57, GCH1_KLEP3A6TBN8, GCH1_KLEP7
Q88ST4, GCH1_LACPLQ38WN0, GCH1_LATSSQ6ACQ1, GCH1_LEIXX
B0S8X8, GCH1_LEPBAQ04P36, GCH1_LEPBJQ056J8, GCH1_LEPBL
B0SRX6, GCH1_LEPBPQ72LY8, GCH1_LEPICQ8EYG1, GCH1_LEPIN
Q92A75, GCH1_LISINC1KWN3, GCH1_LISMCQ71Y82, GCH1_LISMF
B8DBZ3, GCH1_LISMHQ8Y5X1, GCH1_LISMOA0AK45, GCH1_LISW6
B1HTA3, GCH1_LYSSCQ65TR0, GCH1_MANSMQ0AM02, GCH1_MARMM
Q607T5, GCH1_METCAB0U881, GCH1_METS4Q05915, GCH1_MOUSE
P51598, GCH1_MUCPUA0QA85, GCH1_MYCA1B1MGU9, GCH1_MYCA9
P64208, GCH1_MYCBOA1KPU4, GCH1_MYCBPC1AI67, GCH1_MYCBT
A4T5P2, GCH1_MYCGIB8ZU42, GCH1_MYCLBO69531, GCH1_MYCLE
B2HJ53, GCH1_MYCMMQ743Z2, GCH1_MYCPAA5U8T4, GCH1_MYCTA
P9WN56, GCH1_MYCTOP9WN57, GCH1_MYCTUA0PV57, GCH1_MYCUA
A1TG42, GCH1_MYCVPP51599, GCH1_NEUCRQ2Y6B3, GCH1_NITMU
B2J1L7, GCH1_NOSP7P51596, GCH1_ONCMYO61573, GCH1_OSTOS
A6LFE8, GCH1_PARD8P57865, GCH1_PASMUQ6D3N3, GCH1_PECAS
C6DEM6, GCH1_PECCPA5D2D8, GCH1_PELTSQ4FL89, GCH1_PELUB
C0QPU5, GCH1_PERMHQ7N6K7, GCH1_PHOLLQ6LQL4, GCH1_PHOPR
P51600, GCH1_PHYBLB2RIJ1, GCH1_PORG3Q7MWI5, GCH1_PORGI
Q15YG1, GCH1_PSEA6Q3IF89, GCH1_PSET1Q8ZWW5, GCH1_PYRAE
B1YCT7, GCH1_PYRNVQ8XZK8, GCH1_RALN1P22288, GCH1_RAT
Q98LQ6, GCH1_RHILOQ92QB4, GCH1_RHIMEQ7UJJ7, GCH1_RHOBA
Q2IY20, GCH1_RHOP2Q6N4E7, GCH1_RHOPAQ212N0, GCH1_RHOPB
Q134L7, GCH1_RHOPSB3QE25, GCH1_RHOPTC3PNA0, GCH1_RICAE
A8GN89, GCH1_RICAHA8GUB6, GCH1_RICB8Q1RID0, GCH1_RICBR
Q92I93, GCH1_RICCNQ4ULX3, GCH1_RICFEA8F1F2, GCH1_RICM5
Q9ZDE8, GCH1_RICPRC4K2D8, GCH1_RICPUB0BXB8, GCH1_RICRO
A8GRW0, GCH1_RICRSQ68WZ4, GCH1_RICTYB8I184, GCH1_RUMCH
C3NGB7, GCH1_SACI1C3MR62, GCH1_SACI2C3MZ97, GCH1_SACI3
C3MXF1, GCH1_SACI4C4KIH5, GCH1_SACI6C3N7B7, GCH1_SACI7
Q980E8, GCH1_SACS2B5EYP3, GCH1_SALA4A9MK63, GCH1_SALAR
Q57ME6, GCH1_SALCHB5FNJ7, GCH1_SALDCB5R163, GCH1_SALEP
B5RC32, GCH1_SALG2B4TAL5, GCH1_SALHSB4SY26, GCH1_SALNS
Q5PE52, GCH1_SALPAA9N6K0, GCH1_SALPBC0Q0U7, GCH1_SALPC
B5BE43, GCH1_SALPKB4TNQ0, GCH1_SALSVP64210, GCH1_SALTI
P64209, GCH1_SALTYO13774, GCH1_SCHPOA8GC24, GCH1_SERP5
A1S2C7, GCH1_SHEAMB8E4J0, GCH1_SHEB2A3CZJ1, GCH1_SHEB5
A6WIA1, GCH1_SHEB8A9KXZ9, GCH1_SHEB9Q12SG0, GCH1_SHEDO
A3QIQ4, GCH1_SHELPQ8E9L6, GCH1_SHEONA4Y2K7, GCH1_SHEPC
A0L1S4, GCH1_SHESAQ0HE51, GCH1_SHESMQ0HZU8, GCH1_SHESR
A1REU0, GCH1_SHESWB2TVT9, GCH1_SHIB3Q31YW1, GCH1_SHIBS
Q32EN8, GCH1_SHIDSQ0T2X1, GCH1_SHIF8P0A6T8, GCH1_SHIFL
Q3Z053, GCH1_SHISSC3MB45, GCH1_SINFNA6U8C2, GCH1_SINMW
Q2NUE3, GCH1_SODGMQ8VYU3, GCH1_SOLLCQ3K0Y1, GCH1_STRA1
Q8E549, GCH1_STRA3Q8DZI5, GCH1_STRA5Q82EE8, GCH1_STRAW
Q9X8I3, GCH1_STRCOA8AZD8, GCH1_STRGCB1VSG4, GCH1_STRGG
Q8DUG2, GCH1_STRMUP0C0C2, GCH1_STRP1Q04MF9, GCH1_STRP2
P0DB30, GCH1_STRP3B5E6W5, GCH1_STRP4Q5XCA9, GCH1_STRP6
C1CB65, GCH1_STRP7P0A3E9, GCH1_STRP8A2REL9, GCH1_STRPG
B1I918, GCH1_STRPIB8ZL26, GCH1_STRPJP51595, GCH1_STRPN
P0DB31, GCH1_STRPQB2ISL9, GCH1_STRPSP0C0C1, GCH1_STRPY
B5XLE8, GCH1_STRPZP59656, GCH1_STRR6A4W1S9, GCH1_STRS2
A3CKF4, GCH1_STRSVA4VVH1, GCH1_STRSYQ5LYM8, GCH1_STRT1
Q5M391, GCH1_STRT2C1CC81, GCH1_STRZJC1CIH2, GCH1_STRZP
C1CPG4, GCH1_STRZTQ4J8S2, GCH1_SULACB2V9P4, GCH1_SULSY
Q971G9, GCH1_SULTOQ54769, GCH1_SYNE7Q2JR69, GCH1_SYNJA
Q2JPT8, GCH1_SYNJBQ5N623, GCH1_SYNP6Q55759, GCH1_SYNY3
C5BL73, GCH1_TERTTQ47KU5, GCH1_THEFYB0KCE5, GCH1_THEP3
B0K5C1, GCH1_THEPXQ8DJB8, GCH1_THEVBB5YJV0, GCH1_THEYD
C4LDE6, GCH1_TOLATA7N6L2, GCH1_VIBC1Q9KLX5, GCH1_VIBCH
Q87GZ6, GCH1_VIBPAQ8D6I7, GCH1_VIBVUQ7MDE5, GCH1_VIBVY
Q8D2N7, GCH1_WIGBRQ7M933, GCH1_WOLSUQ8PEP3, GCH1_XANAC
Q8P3B0, GCH1_XANCPQ3BM80, GCH1_XANE5B2I4L2, GCH1_XYLF2
Q9PC02, GCH1_XYLFAB0U794, GCH1_XYLFMQ87D63, GCH1_XYLFT
P51601, GCH1_YEASTA1JU09, GCH1_YERE8A7FJL1, GCH1_YERP3
B2JZ02, GCH1_YERPBQ8ZG15, GCH1_YERPEA9R1B1, GCH1_YERPG
B1JQJ4, GCH1_YERPYA0AYZ1, GCH41_BURCHQ39AS8, GCH41_BURL3
B1K3S8, GCH41_BURO0Q1BR24, GCH41_BURO1Q1LPE1, GCH41_CUPMC
Q47IT5, GCH41_DECARA0B338, GCH42_BURCHQ393P5, GCH42_BURL3
B1K5N3, GCH42_BURO0Q1BLY8, GCH42_BURO1Q1LK35, GCH42_CUPMC
Q47BI9, GCH42_DECARQ6FBI2, GCH4_ACIADB2ULP4, GCH4_AKKM8
Q0VMK6, GCH4_ALCBSQ0AA39, GCH4_ALKEHQ5P229, GCH4_AROAE
A1K4Q9, GCH4_AZOSBC1DM03, GCH4_AZOVDQ65ML7, GCH4_BACLD
P94398, GCH4_BACSUQ6MKE9, GCH4_BDEBAQ2KZ16, GCH4_BORA1
Q7WL36, GCH4_BORBRQ7W7P9, GCH4_BORPAA9ITA7, GCH4_BORPD
Q7VV88, GCH4_BORPEB1Z1G3, GCH4_BURA4Q0BAL7, GCH4_BURCM
A9ANA1, GCH4_BURM1A3MBD3, GCH4_BURM7A2S0N7, GCH4_BURM9
Q62DU0, GCH4_BURMAA1UYQ5, GCH4_BURMSA3P7W3, GCH4_BURP0
Q3JKA4, GCH4_BURP1A3NMF5, GCH4_BURP6Q63JF5, GCH4_BURPS
Q2T7N4, GCH4_BURTAA4JLT5, GCH4_BURVGB9MNP4, GCH4_CALBD
A4XG24, GCH4_CALS8A3PH01, GCH4_CERS1Q3J5D3, GCH4_CERS4
A4WQ81, GCH4_CERS5B9KM22, GCH4_CERSKQ1R153, GCH4_CHRSD
B5EDQ6, GCH4_CITBBA8AF20, GCH4_CITK8Q47VM6, GCH4_COLP3
B5Y6R9, GCH4_COPPDQ0K861, GCH4_CUPNHQ474C1, GCH4_CUPPJ
A9C020, GCH4_DELASB8J1Q5, GCH4_DESDAA8ZUJ6, GCH4_DESOH
Q6AMT5, GCH4_DESPSA5EXB0, GCH4_DICNVB5YCT4, GCH4_DICT6
B8DZH0, GCH4_DICTDA8LS52, GCH4_DINSHA4Y119, GCH4_ECTM1
B1YHT1, GCH4_EXIS2C4KZ55, GCH4_EXISAA7HKP2, GCH4_FERNB
Q39R36, GCH4_GEOMGQ74FW8, GCH4_GEOSLC6E7E6, GCH4_GEOSM
A5G8S1, GCH4_GEOURQ2SLC0, GCH4_HAHCHQ9KE60, GCH4_HALH5
A1WYI8, GCH4_HALHLA4G1X0, GCH4_HERARQ31EF8, GCH4_HYDCU
Q5R041, GCH4_IDILOA6SUS5, GCH4_JANMAQ28R88, GCH4_JANSC
Q6U5S4, GCH4_KLEPNC5CEC0, GCH4_KOSOTQ1MPD2, GCH4_LAWIP
B9E8N6, GCH4_MACCJA0L8I1, GCH4_MAGMMC6C0U6, GCH4_MARSD
Q605G6, GCH4_METCAQ1GZD6, GCH4_METFKA2SJ45, GCH4_METPP
Q5F9K6, GCH4_NEIG1A9M3N5, GCH4_NEIM0Q9JV35, GCH4_NEIMA
Q9K023, GCH4_NEIMBA1KT61, GCH4_NEIMFQ0AFY5, GCH4_NITEC
Q82VD1, GCH4_NITEUQ2YCH6, GCH4_NITMUQ3J9J7, GCH4_NITOC
Q727G3, GCH4_NITV2A1VAN0, GCH4_NITV4B8DLK8, GCH4_NITV9
Q8EQK9, GCH4_OCEIHQ30X45, GCH4_OLEA2B1ZTR5, GCH4_OPITP
A1BA17, GCH4_PARDPB2JP67, GCH4_PARP8Q13RX0, GCH4_PARXL
A1AU47, GCH4_PELPDA4SZK2, GCH4_POLAQQ48HN1, GCH4_PSE14
Q15Z55, GCH4_PSEA6B7V776, GCH4_PSEA8Q02DG9, GCH4_PSEAB
Q9HT35, GCH4_PSEAEQ1I2L2, GCH4_PSEE4Q4K3E8, GCH4_PSEF5
C3K4H5, GCH4_PSEFSA8F7Q8, GCH4_PSELTA5W348, GCH4_PSEP1
A6VF17, GCH4_PSEP7Q3K4B0, GCH4_PSEPFB0KR89, GCH4_PSEPG
Q88HM9, GCH4_PSEPKB1JFN3, GCH4_PSEPWQ882P7, GCH4_PSESM
Q3ILJ5, GCH4_PSET1Q4ZU60, GCH4_PSEU2A1STF0, GCH4_PSYIN
Q8XX96, GCH4_RALN1Q168P4, GCH4_ROSDOQ5LTR1, GCH4_RUEPO
Q1GF96, GCH4_RUESTA1AVX5, GCH4_RUTMCA8GF39, GCH4_SERP5
A7WZ02, GCH4_STAA1A6TZ43, GCH4_STAA2Q2FJ74, GCH4_STAA3
Q2G0L1, GCH4_STAA8A5IQC0, GCH4_STAA9Q2YS98, GCH4_STAAB
Q5HIA9, GCH4_STAACA6QEL9, GCH4_STAAEQ99W43, GCH4_STAAM
Q7A777, GCH4_STAANQ6GJA3, GCH4_STAARQ6GBS1, GCH4_STAAS
A8YZR4, GCH4_STAATQ8NXX2, GCH4_STAAWB9DKT0, GCH4_STACT
Q5HRI1, GCH4_STAEQQ8CTR6, GCH4_STAESQ4L3P5, GCH4_STAHJ
Q49VB3, GCH4_STAS1Q2LUP0, GCH4_SYNASQ3A091, GCH4_SYNC1
A0LQR3, GCH4_SYNFMB7ICT4, GCH4_THEABA6LKE7, GCH4_THEM4
Q9WXP6, GCH4_THEMAB9K795, GCH4_THENNA5IL29, GCH4_THEP1
B1LAA9, GCH4_THESQQ3SKF2, GCH4_THIDAA5CXA1, GCH4_VESOH
Q8PLL4, GCH4_XANACQ4UTV2, GCH4_XANC8B0RTU4, GCH4_XANCB
Q8P9T3, GCH4_XANCPQ3BUL9, GCH4_XANE5Q2P374, GCH4_XANOM
B2SJL4, GCH4_XANOPQ5H0A0, GCH4_XANORB2IAI3, GCH4_XYLF2
Q9PBP4, GCH4_XYLFAB0U741, GCH4_XYLFMQ87DA5, GCH4_XYLFT
Q9ZKP2, GTPC1_HELPJO25613, GTPC1_HELPY

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