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ENZYME

ENZYME entry: EC 3.5.4.36

PURL: https://purl.expasy.org/enzyme/EC/3.5.4.36
Accepted Name
mRNA(cytosine(6666)) deaminase
Alternative Name(s)
apolipoprotein B mRNA editing enzyme
Reaction catalysed
cytidine(6666) in apoB mRNA + H2O + H(+) = uridine(6666) in apoB mRNA + NH4(+)
Comment(s)
  • The apolipoprotein B mRNA editing enzyme complex catalyzes the editing of apolipoprotein B mRNA at cytidine(6666) to uridine, thereby transforming the codon for glutamine-2153 to a termination codon.
  • Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport.
  • The catalytic component (APOBEC-1) contains zinc at the active site.
Cross-references
BRENDA3.5.4.36
EC2PDB3.5.4.36
ExplorEnz3.5.4.36
KEGG Ligand Database for Enzyme Nomenclature3.5.4.36
IUBMB Enzyme Nomenclature3.5.4.36
MEDLINEFind literature relating to 3.5.4.36
MetaCyc3.5.4.36
Rhea expert-curated reactions3.5.4.36
UniProtKB/Swiss-Prot
P41238, ABEC1_HUMANQ9EQP0, ABEC1_MESAUQ9TUI7, ABEC1_MONDO
P51908, ABEC1_MOUSEQ694B3, ABEC1_PONPYP47855, ABEC1_RABIT
P38483, ABEC1_RATQ3SYR3, ABEC2_BOVINQ9Y235, ABEC2_HUMAN
Q9WV35, ABEC2_MOUSEQ694B4, ABEC2_PONPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-