ENZYME entry: EC 3.5.4.36
Accepted Name |
mRNA(cytosine(6666)) deaminase.
|
Alternative Name(s) |
Apolipoprotein B mRNA editing enzyme. |
Reaction catalysed |
Cytosine(6666) in apolipoprotein B mRNA + H(2)O <=> uracil(6666) in apolipoprotein B mRNA + NH(3) |
Comment(s) |
- The apolipoprotein B mRNA editing enzyme complex catalyzes the
editing of apolipoprotein B mRNA at cytidine(6666) to uridine,
thereby transforming the codon for glutamine-2153 to a termination
codon.
- Editing results in translation of a truncated apolipoprotein B
isoform (apoB-48) with distinct functions in lipid transport.
- The catalytic component (APOBEC-1) contains zinc at the active site.
|
Cross-references |
BRENDA | 3.5.4.36 |
EC2PDB | 3.5.4.36 |
ExplorEnz | 3.5.4.36 |
PRIAM enzyme-specific profiles | 3.5.4.36 |
KEGG Ligand Database for Enzyme Nomenclature | 3.5.4.36 |
IUBMB Enzyme Nomenclature | 3.5.4.36 |
IntEnz | 3.5.4.36 |
MEDLINE | Find literature relating to 3.5.4.36 |
MetaCyc | 3.5.4.36 |
Rhea expert-curated reactions | 3.5.4.36 |
UniProtKB/Swiss-Prot |
P41238, ABEC1_HUMAN; | Q9EQP0, ABEC1_MESAU; | Q9TUI7, ABEC1_MONDO; |
P51908, ABEC1_MOUSE; | Q694B3, ABEC1_PONPY; | P47855, ABEC1_RABIT; |
P38483, ABEC1_RAT; | Q3SYR3, ABEC2_BOVIN; | Q9Y235, ABEC2_HUMAN; |
Q9WV35, ABEC2_MOUSE; | Q694B4, ABEC2_PONPY; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-