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ENZYME entry: EC 3.5.4.36

Accepted Name
mRNA(cytosine(6666)) deaminase.
Alternative Name(s)
apolipoprotein B mRNA editing enzyme.
Reaction catalysed
cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA
Comment(s)
  • The apolipoprotein B mRNA editing enzyme complex catalyzes the editing of apolipoprotein B mRNA at cytidine(6666) to uridine, thereby transforming the codon for glutamine-2153 to a termination codon.
  • Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport.
  • The catalytic component (APOBEC-1) contains zinc at the active site.
Cross-references
BRENDA3.5.4.36
EC2PDB3.5.4.36
ExplorEnz3.5.4.36
PRIAM enzyme-specific profiles3.5.4.36
KEGG Ligand Database for Enzyme Nomenclature3.5.4.36
IUBMB Enzyme Nomenclature3.5.4.36
IntEnz3.5.4.36
MEDLINEFind literature relating to 3.5.4.36
MetaCyc3.5.4.36
Rhea expert-curated reactions3.5.4.36
UniProtKB/Swiss-Prot
P41238, ABEC1_HUMAN;  Q9EQP0, ABEC1_MESAU;  Q9TUI7, ABEC1_MONDO;  
P51908, ABEC1_MOUSE;  Q694B3, ABEC1_PONPY;  P47855, ABEC1_RABIT;  
P38483, ABEC1_RAT;  Q3SYR3, ABEC2_BOVIN;  Q9Y235, ABEC2_HUMAN;  
Q9WV35, ABEC2_MOUSE;  Q694B4, ABEC2_PONPY;  

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