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ENZYME entry: EC 3.5.4.38

Accepted Name
Single-stranded DNA cytosine deaminase.
Alternative Name(s)
Activation-induced cytidine deaminase.
Activation-induced deaminase.
Reaction catalysed
Cytosine in single-stranded DNA + H(2)O <=> uracil in single-stranded DNA + NH(3)
Comment(s)
  • The enzyme exclusively catalyzes deamination of cytosine in single- stranded DNA.
  • It preferentially deaminates five-nucleotide bubbles.
  • The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G).
  • The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
Cross-references
BRENDA3.5.4.38
EC2PDB3.5.4.38
ExplorEnz3.5.4.38
PRIAM enzyme-specific profiles3.5.4.38
KEGG Ligand Database for Enzyme Nomenclature3.5.4.38
IUBMB Enzyme Nomenclature3.5.4.38
IntEnz3.5.4.38
MEDLINEFind literature relating to 3.5.4.38
MetaCyc3.5.4.38
UniProtKB/Swiss-Prot
Q4VDN5, AB3CA_FELCA;  P31941, ABC3A_HUMAN;  Q9UH17, ABC3B_HUMAN;  
Q694B5, ABC3C_GORGO;  Q9NRW3, ABC3C_HUMAN;  Q96AK3, ABC3D_HUMAN;  
Q8IUX4, ABC3F_HUMAN;  A9QA56, ABC3H_FELCA;  Q6NTF7, ABC3H_HUMAN;  
Q19Q52, ABC3H_MACMU;  Q1WBT4, ABC3H_PONPY;  P60704, ABEC3_CRILO;  
Q99J72, ABEC3_MOUSE;  P60705, ABEC3_RAT;  Q2PT36, AICDA_BOVIN;  
Q75W64, AICDA_CANLF;  Q9GZX7, AICDA_HUMAN;  Q9WVE0, AICDA_MOUSE;  

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