ENZYME entry: EC 3.5.99.12

PURL: https://purl.expasy.org/enzyme/EC/3.5.99.12

Accepted Name
salsolinol synthase
Alternative Name(s)
Sal synthase
Reaction catalysed
dopamine + acetaldehyde = (R)-salsolinol + H2O
Comment(s)
The enzyme, present in mammalian brains, forms the catechol isoquinoline (R)-salsolinol. This compound can be metabolized to (R)-N-methylsalsolinol, a 1-methyl-4-phenylpyridinium-like neurotoxin that impairs the function of dopaminergic neurons, causing the clinical symptoms of Parkinson's disease.
Cross-references
BRENDA	3.5.99.12
EC2PDB	3.5.99.12
ExplorEnz	3.5.99.12
KEGG Ligand Database for Enzyme Nomenclature	3.5.99.12
IUBMB Enzyme Nomenclature	3.5.99.12
MEDLINE	Find literature relating to 3.5.99.12
MetaCyc	3.5.99.12
Rhea expert-curated reactions	3.5.99.12

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
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