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ENZYME

ENZYME entry: EC 3.5.99.14

PURL: https://purl.expasy.org/enzyme/EC/3.5.99.14
Accepted Name
(S)-norcoclaurine synthase
Alternative Name(s)
(S)-norlaudanosoline synthase
Reaction catalysed
(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O
Comment(s)
  • The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates.
  • The product is the precursor of the benzylisoquinoline alkaloids in plants.
  • The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.
  • Formerly EC 4.2.1.78.
Cross-references
BRENDA3.5.99.14
EC2PDB3.5.99.14
ExplorEnz3.5.99.14
KEGG Ligand Database for Enzyme Nomenclature3.5.99.14
IUBMB Enzyme Nomenclature3.5.99.14
MEDLINEFind literature relating to 3.5.99.14
MetaCyc3.5.99.14
Rhea expert-curated reactions3.5.99.14
UniProtKB/Swiss-Prot
A2A1A0, NCS1_COPJAQ4QTJ2, NCS1_PAPSOA2A1A1, NCS2_COPJA
Q4QTJ1, NCS2_PAPSOQ67A25, NCS_THLFG

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