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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.1.55

Accepted Name
8-oxo-dGTP diphosphatase.
Alternative Name(s)
7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase.
7,8-dihydro-8-oxoguanine triphosphatase.
8-oxo-dGTPase.
Reaction catalysed
8-oxo-dGTP + H(2)O <=> 8-oxo-dGMP + diphosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA.
  • It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
Cross-references
BRENDA3.6.1.55
EC2PDB3.6.1.55
ExplorEnz3.6.1.55
PRIAM enzyme-specific profiles3.6.1.55
KEGG Ligand Database for Enzyme Nomenclature3.6.1.55
IUBMB Enzyme Nomenclature3.6.1.55
IntEnz3.6.1.55
MEDLINEFind literature relating to 3.6.1.55
MetaCyc3.6.1.55
UniProtKB/Swiss-Prot
F1P963, 8ODP_CANLF;  P36639, 8ODP_HUMAN;  P53368, 8ODP_MOUSE;  
P53369, 8ODP_RAT;  P9WIY2, MUTT1_MYCTO;  P9WIY3, MUTT1_MYCTU;  
P9WIY0, MUTT2_MYCTO;  P9WIY1, MUTT2_MYCTU;  P9WIX8, MUTT3_MYCTO;  
P9WIX9, MUTT3_MYCTU;  P96590, MUTT_BACSU;  P57298, MUTT_BUCAI;  
Q8K9U2, MUTT_BUCAP;  P08337, MUTT_ECOLI;  P44932, MUTT_HAEIN;  
P32090, MUTT_PROVU;  P95781, MUTX_STRMU;  P41354, MUTX_STRPN;  
P59659, MUTX_STRR6;  Q9CA40, NUDT1_ARATH;  Q12524, PCD1_YEAST;  
O35013, YTKD_BACSU;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-