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ENZYME entry: EC 3.6.1.56

Accepted Name
2-hydroxy-dATP diphosphatase.
Alternative Name(s)
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase.
Oxidized purine nucleoside triphosphatase.
Reaction catalysed
2-hydroxy-dATP + H(2)O <=> 2-hydroxy-dAMP + diphosphate
Comment(s)
  • The enzyme hydrolyzes oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA.
  • It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55).
Cross-references
BRENDA3.6.1.56
EC2PDB3.6.1.56
ExplorEnz3.6.1.56
PRIAM enzyme-specific profiles3.6.1.56
KEGG Ligand Database for Enzyme Nomenclature3.6.1.56
IUBMB Enzyme Nomenclature3.6.1.56
IntEnz3.6.1.56
MEDLINEFind literature relating to 3.6.1.56
MetaCyc3.6.1.56
UniProtKB/Swiss-Prot
F1P963, 8ODP_CANLF;  P36639, 8ODP_HUMAN;  P53368, 8ODP_MOUSE;  
P53369, 8ODP_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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