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ENZYME

ENZYME entry: EC 3.6.1.56

Accepted Name
2-hydroxy-dATP diphosphatase
Alternative Name(s)
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase
oxidized purine nucleoside triphosphatase
Reaction catalysed
2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)
Comment(s)
  • The enzyme hydrolyzes oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA.
  • It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55).
Cross-references
BRENDA3.6.1.56
EC2PDB3.6.1.56
ExplorEnz3.6.1.56
KEGG Ligand Database for Enzyme Nomenclature3.6.1.56
IUBMB Enzyme Nomenclature3.6.1.56
MEDLINEFind literature relating to 3.6.1.56
MetaCyc3.6.1.56
Rhea expert-curated reactions3.6.1.56
UniProtKB/Swiss-Prot
F1P963, 8ODP_CANLFQ7ZWC3, 8ODP_DANREP36639, 8ODP_HUMAN
P53368, 8ODP_MOUSEP53369, 8ODP_RATQ12524, PCD1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-