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ENZYME

ENZYME entry: EC 3.6.1.59

Accepted Name
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
Alternative Name(s)
m(7)GpppN m(7)GMP phosphohydrolase
m(7)GpppX diphosphatase
m(7)GpppX pyrophosphatase
Reaction catalysed
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP
Comment(s)
  • The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides.
  • Decapping is an important process in the control of eukaryotic mRNA degradation.
  • The enzyme functions to clear the cell of cap structure following decay of the RNA body.
  • The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA].
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.59
EC2PDB3.6.1.59
ExplorEnz3.6.1.59
PRIAM enzyme-specific profiles3.6.1.59
KEGG Ligand Database for Enzyme Nomenclature3.6.1.59
IUBMB Enzyme Nomenclature3.6.1.59
IntEnz3.6.1.59
MEDLINEFind literature relating to 3.6.1.59
MetaCyc3.6.1.59
Rhea expert-curated reactions3.6.1.59
UniProtKB/Swiss-Prot
D3K0N9, DCPS_ASCSUQ8MJJ7, DCPS_BOVING5EFS4, DCPS_CAEEL
Q96C86, DCPS_HUMANQ9DAR7, DCPS_MOUSEQ8MIZ3, DCPS_PIG
Q8K4F7, DCPS_RATQ9P7C9, DCPS_SCHPOQ06151, DCPS_YEAST
A2VE79, NUDT3_BOVINO95989, NUDT3_HUMANQ9JI46, NUDT3_MOUSE
Q566C7, NUDT3_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
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