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ENZYME entry: EC 3.6.1.69

Accepted Name
8-oxo-(d)GTP phosphatase.
Reaction catalysed
  • 8-oxo-GTP + H(2)O <=> 8-oxo-GDP + phosphate
  • 8-oxo-dGTP + H(2)O <=> 8-oxo-dGDP + phosphate
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyzes the hydrolysis of both 8-oxo-GTP and 8-oxo- dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage.
  • The enzyme is highly specific.
  • Unlike EC 3.6.1.55, it removes only a single phosphate group.
  • The nucleoside diphosphate products are hydrolyzed further by EC 3.6.1.58.
Cross-references
BRENDA3.6.1.69
EC2PDB3.6.1.69
ExplorEnz3.6.1.69
PRIAM enzyme-specific profiles3.6.1.69
KEGG Ligand Database for Enzyme Nomenclature3.6.1.69
IUBMB Enzyme Nomenclature3.6.1.69
IntEnz3.6.1.69
MEDLINEFind literature relating to 3.6.1.69
MetaCyc3.6.1.69
Rhea expert-curated reactions3.6.1.69
UniProtKB/Swiss-Prot
A0QUZ2, MUTT1_MYCS2;  P9WIY2, MUTT1_MYCTO;  P9WIY3, MUTT1_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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