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ENZYME

ENZYME entry: EC 3.6.1.9

Accepted Name
nucleotide diphosphatase
Alternative Name(s)
dinucleotide nucleotidohydrolase
nucleoside-triphosphate diphosphatase
nucleotide pyrophosphatase
Reaction catalysed
  • a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)
  • a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
Comment(s)
  • The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates.
  • In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA.
  • Formerly EC 3.6.1.19.
Cross-references
BRENDA3.6.1.9
EC2PDB3.6.1.9
ExplorEnz3.6.1.9
PRIAM enzyme-specific profiles3.6.1.9
KEGG Ligand Database for Enzyme Nomenclature3.6.1.9
IUBMB Enzyme Nomenclature3.6.1.9
IntEnz3.6.1.9
MEDLINEFind literature relating to 3.6.1.9
MetaCyc3.6.1.9
Rhea expert-curated reactions3.6.1.9
UniProtKB/Swiss-Prot
O95671, ASML_HUMANA0A2L0V161, DGTPH_BPPMBA0A7U3TBV3, DGTPH_BPS2L
A0A2H5BHG5, DGTPH_BPSHAP22413, ENPP1_HUMANP06802, ENPP1_MOUSE
Q924C3, ENPP1_RATP15396, ENPP3_BOVINO14638, ENPP3_HUMAN
Q6DYE8, ENPP3_MOUSEQ5R5M5, ENPP3_PONABP97675, ENPP3_RAT
Q4DBX5, ITPA1_TRYCCQ4DRX4, ITPA2_TRYCCQ16YB3, ITPA_AEDAE
C0NE84, ITPA_AJECGQ7Q4F5, ITPA_ANOGAQ8L968, ITPA_ARATH
Q4WTN9, ITPA_ASPFUQ2TX99, ITPA_ASPORF4P9L8, ITPA_BATDJ
Q2KIC5, ITPA_BOVINA8XZP2, ITPA_CAEBRQ9GYG4, ITPA_CAEEL
Q59N80, ITPA_CANALC4YRQ5, ITPA_CANAWQ6FUV2, ITPA_CANGA
Q2GW61, ITPA_CHAGBF1NLH9, ITPA_CHICKF6Y089, ITPA_CIOIN
E3QBC5, ITPA_COLGMA8NZ80, ITPA_COPC7Q5KPF3, ITPA_CRYNJ
B0XL39, ITPA_CULQUA5WVX0, ITPA_DANREQ6BIT7, ITPA_DEBHA
Q54LQ6, ITPA_DICDIQ9VMW7, ITPA_DROMEC8V9B7, ITPA_EMENI
Q8SS24, ITPA_ENCCUE0S6S0, ITPA_ENCITQ752Z9, ITPA_EREGS
C7YTE3, ITPA_FUSV7A8BKZ6, ITPA_GIAICQ9BY32, ITPA_HUMAN
Q6CV82, ITPA_KLULAQ4Q0V1, ITPA_LEIMAA4R1J6, ITPA_MAGO7
B6TNW8, ITPA_MAIZEC1FI13, ITPA_MICCCA9VE54, ITPA_MONBE
Q9D892, ITPA_MOUSEA7RWC9, ITPA_NEMVEQ1K4R6, ITPA_NEUCR
B8BH95, ITPA_ORYSIQ7XDP2, ITPA_ORYSJE0VVF6, ITPA_PEDHC
Q0UFP3, ITPA_PHANOD0MY11, ITPA_PHYITA3LVK6, ITPA_PICST
Q8IBP3, ITPA_PLAF7B2B5Q3, ITPA_PODANE3KAB5, ITPA_PUCGT
D3ZW55, ITPA_RATQ9UU89, ITPA_SCHPOC5WZH0, ITPA_SORBI
D5GCI8, ITPA_TUBMMQ4PD06, ITPA_USTMAF6HS55, ITPA_VITVI
Q2NLA8, ITPA_XENLAQ6CDL9, ITPA_YARLIP47119, ITPA_YEAST
Q9X015, MAZG_THEMAP25353, NPP1_YEASTP39997, NPP2_YEAST
Q8G4U8, NTPNH_BIFLOQ28VZ8, NTPP1_JANSCQ28NC5, NTPP2_JANSC
A3DBJ9, NTPPA_ACET2A9NE14, NTPPA_ACHLIQ6FDX8, NTPPA_ACIAD
C4ZDP0, NTPPA_AGARVQ8UHX5, NTPPA_AGRFCB2UPE6, NTPPA_AKKM8
Q21WP7, NTPPA_ALBFTQ0VS67, NTPPA_ALCBSQ5E7X6, NTPPA_ALIF1
Q5WEQ9, NTPPA_ALKCKQ0ABM5, NTPPA_ALKEHA6TQH7, NTPPA_ALKMQ
A8MHM5, NTPPA_ALKOOB8JH92, NTPPA_ANAD2Q2IKU4, NTPPA_ANADE
A7HA27, NTPPA_ANADFB4UJ23, NTPPA_ANASKO67613, NTPPA_AQUAE
Q5P2U3, NTPPA_AROAEC3P9E0, NTPPA_BACAAC3L6Y6, NTPPA_BACAC
Q81LD6, NTPPA_BACANB7JQ48, NTPPA_BACC0Q72ZX1, NTPPA_BACC1
B7IIW6, NTPPA_BACC2C1ETQ1, NTPPA_BACC3B7HE87, NTPPA_BACC4
B7HQL2, NTPPA_BACC7A7GTD6, NTPPA_BACCNB9IZ30, NTPPA_BACCQ
Q817R9, NTPPA_BACCRQ633Y9, NTPPA_BACCZQ5LAQ8, NTPPA_BACFN
Q64R56, NTPPA_BACFRQ6HD71, NTPPA_BACHKQ65GL2, NTPPA_BACLD
A9VIS9, NTPPA_BACMKA8FFU1, NTPPA_BACP2Q02169, NTPPA_BACSU
Q8A749, NTPPA_BACTNA7Z794, NTPPA_BACVZQ6G253, NTPPA_BARHE
Q6G132, NTPPA_BARQUQ6MQJ7, NTPPA_BDEBAQ2KYV3, NTPPA_BORA1
Q7WL84, NTPPA_BORBRQ7W7U4, NTPPA_BORPAQ7VWE3, NTPPA_BORPE
Q89V00, NTPPA_BRADUA5EAG4, NTPPA_BRASBQ2YPC2, NTPPA_BRUA2
Q57FA3, NTPPA_BRUABQ8YF55, NTPPA_BRUMEQ8G2R6, NTPPA_BRUSU
Q39E95, NTPPA_BURL3Q62II4, NTPPA_BURMAQ1BUW3, NTPPA_BURO1
Q3JUG5, NTPPA_BURP1Q63VT5, NTPPA_BURPSQ2SZT6, NTPPA_BURTA
B9MRU6, NTPPA_CALBDQ8RBC6, NTPPA_CALS4A4XKL5, NTPPA_CALS8
Q3AF81, NTPPA_CARHZQ9A5V5, NTPPA_CAUVCQ3J086, NTPPA_CERS4
Q11LY4, NTPPA_CHESBQ5L6G5, NTPPA_CHLABQ3AQS4, NTPPA_CHLCH
Q823U1, NTPPA_CHLCVQ253S7, NTPPA_CHLFFQ3B3P0, NTPPA_CHLL3
B3QNY9, NTPPA_CHLP8A4SE83, NTPPA_CHLPMB0B7R8, NTPPA_CHLT2
Q3KM09, NTPPA_CHLTAB0BBY3, NTPPA_CHLTBQ8KDS1, NTPPA_CHLTE
O84353, NTPPA_CHLTRA0M2D8, NTPPA_CHRFKQ1QVC0, NTPPA_CHRSD
Q7P1T8, NTPPA_CHRVOB5EHR3, NTPPA_CITBBQ97JN3, NTPPA_CLOAB
A7FXW4, NTPPA_CLOB1C3L3L1, NTPPA_CLOB6A6LQP7, NTPPA_CLOB8
B2V089, NTPPA_CLOBAB2TK54, NTPPA_CLOBBA5I684, NTPPA_CLOBH
C1FVY3, NTPPA_CLOBJB1IM03, NTPPA_CLOBKA7GHM0, NTPPA_CLOBL
B1KZT1, NTPPA_CLOBMQ18B07, NTPPA_CLOD6B9E003, NTPPA_CLOK1
A5N6I4, NTPPA_CLOK5A0PZG3, NTPPA_CLONNQ0TNG7, NTPPA_CLOP1
Q8XIH4, NTPPA_CLOPEQ0SR36, NTPPA_CLOPSQ892M0, NTPPA_CLOTE
Q47VG7, NTPPA_COLP3Q1LQB1, NTPPA_CUPMCQ46Y94, NTPPA_CUPPJ
Q11VI6, NTPPA_CYTH3Q47JQ0, NTPPA_DECARQ3Z7G4, NTPPA_DEHM1
A5FQJ4, NTPPA_DEHMBQ3ZY38, NTPPA_DEHMCQ1IYX1, NTPPA_DEIGD
Q9RV24, NTPPA_DEIRAQ24SM2, NTPPA_DESHYQ6AMI5, NTPPA_DESPS
A4J7K7, NTPPA_DESRMQ72EP2, NTPPA_DESVHB5YF11, NTPPA_DICT6
B8E0U2, NTPPA_DICTDP58629, NTPPA_ECO57Q0TCL8, NTPPA_ECOL5
Q8FD47, NTPPA_ECOL6P25536, NTPPA_ECOLIQ1R692, NTPPA_ECOUT
B2KC30, NTPPA_ELUMPQ82ZA4, NTPPA_ENTFAB1YJT1, NTPPA_EXIS2
A5FFP4, NTPPA_FLAJ1A6GZH5, NTPPA_FLAPJQ8RFE6, NTPPA_FUSNN
Q5KWN2, NTPPA_GEOKAQ39X87, NTPPA_GEOMGQ74A46, NTPPA_GEOSL
C6E559, NTPPA_GEOSMC5D5H8, NTPPA_GEOSWA5G7S1, NTPPA_GEOUR
Q7NH22, NTPPA_GLOVIQ5FS71, NTPPA_GLUOXQ0BTC5, NTPPA_GRABC
Q2SBH1, NTPPA_HAHCHQ9K8H3, NTPPA_HALH5Q31FH4, NTPPA_HYDCU
Q0C2H1, NTPPA_HYPNAQ5QWE2, NTPPA_IDILOQ1IV55, NTPPA_KORVE
B3W9W2, NTPPA_LACCBQ035Z4, NTPPA_LACP3A9KHL6, NTPPA_LACP7
Q38YR2, NTPPA_LATSSQ1MQH1, NTPPA_LAWIPB0S919, NTPPA_LEPBA
Q04NX0, NTPPA_LEPBJQ04XA6, NTPPA_LEPBLB0SK44, NTPPA_LEPBP
Q72WC1, NTPPA_LEPICQ8FA20, NTPPA_LEPINQ2W1Y3, NTPPA_MAGSA
Q0AQL3, NTPPA_MARMMQ8TSP7, NTPPA_METACQ46BZ6, NTPPA_METBF
Q12TU6, NTPPA_METBUQ60BT7, NTPPA_METCAQ1GZF7, NTPPA_METFK
Q8PVQ2, NTPPA_METMAQ2RL24, NTPPA_MOOTAQ1D912, NTPPA_MYXXD
Q5FA52, NTPPA_NEIG1Q9JVK3, NTPPA_NEIMAQ9K0J8, NTPPA_NEIMB
Q82XC7, NTPPA_NITEUQ1QRF9, NTPPA_NITHXQ2YC50, NTPPA_NITMU
Q3J7T5, NTPPA_NITOCQ3SVZ7, NTPPA_NITWNQ2G9H1, NTPPA_NOVAD
Q315F5, NTPPA_OLEA2A6L8E5, NTPPA_PARD8Q6MDL5, NTPPA_PARUW
Q142M3, NTPPA_PARXLQ9CLG6, NTPPA_PASMUQ6DAI3, NTPPA_PECAS
B4SA80, NTPPA_PELPBA5D426, NTPPA_PELTSQ7N035, NTPPA_PHOLL
Q6LMA4, NTPPA_PHOPRA6L391, NTPPA_PHOV8Q12C38, NTPPA_POLSJ
B2RIL9, NTPPA_PORG3Q7MWG0, NTPPA_PORGIQ48E97, NTPPA_PSE14
Q15ZH0, NTPPA_PSEA6Q9HVU3, NTPPA_PSEAEQ4KIA3, NTPPA_PSEF5
Q3KI22, NTPPA_PSEPFQ88PB4, NTPPA_PSEPKQ87WS4, NTPPA_PSESM
Q3IFH5, NTPPA_PSET1Q4ZNT2, NTPPA_PSEU2Q4FUF9, NTPPA_PSYA2
Q1QDI9, NTPPA_PSYCKQ9UXZ1, NTPPA_PYRABQ8U476, NTPPA_PYRFU
O59604, NTPPA_PYRHOP58634, NTPPA_RALN1Q2KCN4, NTPPA_RHIEC
Q1MLP2, NTPPA_RHIL3Q989F1, NTPPA_RHILOQ92S22, NTPPA_RHIME
Q7UWY8, NTPPA_RHOBAQ2IRX7, NTPPA_RHOP2Q6N181, NTPPA_RHOPA
Q20Y49, NTPPA_RHOPBQ130J6, NTPPA_RHOPSQ2RQN0, NTPPA_RHORT
Q169N3, NTPPA_ROSDOQ1AVT5, NTPPA_RUBXDQ5LLE9, NTPPA_RUEPO
Q1GLE1, NTPPA_RUESTB8I6Q1, NTPPA_RUMCHQ21FT3, NTPPA_SACD2
Q57J97, NTPPA_SALCHQ5PJV0, NTPPA_SALPAQ2S4I1, NTPPA_SALRD
P58631, NTPPA_SALTIP58630, NTPPA_SALTYO14141, NTPPA_SCHPO
Q12IW9, NTPPA_SHEDOQ07WQ2, NTPPA_SHEFNQ8EA14, NTPPA_SHEON
Q0HEI2, NTPPA_SHESMQ0HZH0, NTPPA_SHESRQ31WB6, NTPPA_SHIBS
Q32B92, NTPPA_SHIDSQ3YX01, NTPPA_SHISSQ1GRU5, NTPPA_SPHAL
A3DMH6, NTPPA_STAMFQ67SI8, NTPPA_SYMTHQ2LSD6, NTPPA_SYNAS
Q3A7I0, NTPPA_SYNC1Q0AWG2, NTPPA_SYNWWB7IFS5, NTPPA_THEAB
C5A216, NTPPA_THEGJQ5JI98, NTPPA_THEKOA6LJI7, NTPPA_THEM4
Q9X1P2, NTPPA_THEMAB6YWV3, NTPPA_THEONA5IM27, NTPPA_THEP1
B0KAE1, NTPPA_THEP3B0K437, NTPPA_THEPXB9KXM8, NTPPA_THERP
B1LB65, NTPPA_THESQQ72JE7, NTPPA_THET2Q5SJ26, NTPPA_THET8
Q3SG65, NTPPA_THIDAQ73K74, NTPPA_TREDEQ9KUU7, NTPPA_VIBCH
Q87LC4, NTPPA_VIBPAQ8DCG8, NTPPA_VIBVUQ7MHE0, NTPPA_VIBVY
Q73I47, NTPPA_WOLPMB3CL80, NTPPA_WOLPPQ5GT91, NTPPA_WOLTR
C0R2U8, NTPPA_WOLWRQ8PIX4, NTPPA_XANACQ3BRF4, NTPPA_XANC5
Q4UWJ9, NTPPA_XANC8Q8P7K1, NTPPA_XANCPQ2P0P1, NTPPA_XANOM
Q5GXK1, NTPPA_XANORQ99210, NTPPA_YEASTQ1C1M9, NTPPA_YERPA
P58636, NTPPA_YERPEQ1CDV0, NTPPA_YERPNQ665F6, NTPPA_YERPS
Q5NNS3, NTPPA_ZYMMOB0C1T2, NTPP_ACAM1Q6FB05, NTPP_ACIAD
Q8UJC6, NTPP_AGRFCB9KIX1, NTPP_ANAMFQ5PAF5, NTPP_ANAMM
Q2GKV0, NTPP_ANAPZQ89WP0, NTPP_BRADUA8FKT3, NTPP_CAMJ8
A7H4N2, NTPP_CAMJDQ9PI04, NTPP_CAMJEA1VYL9, NTPP_CAMJJ
Q5HVQ6, NTPP_CAMJRQ9AC58, NTPP_CAUVCQ3IYH0, NTPP_CERS4
Q9PK45, NTPP_CHLMUQ9Z9F9, NTPP_CHLPNC3PEA3, NTPP_CORA7
Q6NIW2, NTPP_CORDIQ8FRM5, NTPP_COREFA4QC50, NTPP_CORGB
Q8NSH0, NTPP_CORGLQ4JTL6, NTPP_CORJKQ6A725, NTPP_CUTAK
B8HN65, NTPP_CYAP4B1I4S1, NTPP_DESAPQ55G28, NTPP_DICDI
Q3YRV1, NTPP_EHRCJQ2GGV6, NTPP_EHRCRQ5FGZ7, NTPP_EHRRG
Q5HB21, NTPP_EHRRWB7KJY0, NTPP_GLOC7Q5FS37, NTPP_GLUOX
Q0BWA0, NTPP_GRABCQ7VKR7, NTPP_HAEDUB6JN80, NTPP_HELP2
B5Z8N5, NTPP_HELPGQ1CS23, NTPP_HELPHQ9ZJY6, NTPP_HELPJ
B2UV03, NTPP_HELPSO25838, NTPP_HELPYQ0C6A7, NTPP_HYPNA
Q5X3L5, NTPP_LEGPAA5IDM1, NTPP_LEGPCQ5ZTX2, NTPP_LEGPH
Q5WV03, NTPP_LEGPLQ6AGN3, NTPP_LEIXXQ2VYH3, NTPP_MAGSA
Q0AKD7, NTPP_MARMMB0JH94, NTPP_MICANQ7TWT7, NTPP_MYCBO
A1KNT4, NTPP_MYCBPC1AH56, NTPP_MYCBTA4TF31, NTPP_MYCGI
B8ZUX8, NTPP_MYCLBQ49670, NTPP_MYCLEB2HEK5, NTPP_MYCMM
Q73UG7, NTPP_MYCPAA0QTE5, NTPP_MYCS2A3PW53, NTPP_MYCSJ
A1UCG3, NTPP_MYCSKQ1BCI0, NTPP_MYCSSA5U7V6, NTPP_MYCTA
P9WK26, NTPP_MYCTOP9WK27, NTPP_MYCTUA0PRJ3, NTPP_MYCUA
A1T5Q3, NTPP_MYCVPQ1DAV2, NTPP_MYXXDQ2GCP9, NTPP_NEOSM
Q1QRY3, NTPP_NITHXA6Q573, NTPP_NITSBQ3SWH0, NTPP_NITWN
Q5Z154, NTPP_NOCFAB2J6P8, NTPP_NOSP7P58632, NTPP_NOSS1
Q2GC58, NTPP_NOVADA5CCC1, NTPP_ORITBQ7U5K1, NTPP_PARMW
Q4FNS4, NTPP_PELUBA3PDZ9, NTPP_PROM0A2C3V6, NTPP_PROM1
A8G5U9, NTPP_PROM2A2C7X9, NTPP_PROM3Q319X8, NTPP_PROM9
Q7VB43, NTPP_PROMAQ7V6H8, NTPP_PROMMQ7V0U3, NTPP_PROMP
A2BS59, NTPP_PROMSQ46JR8, NTPP_PROMTC0ZWV2, NTPP_RHOE4
Q0S319, NTPP_RHOJRC1B1A6, NTPP_RHOOBQ2J353, NTPP_RHOP2
Q6ND10, NTPP_RHOPAQ21CL6, NTPP_RHOPBQ13E26, NTPP_RHOPS
Q2RN87, NTPP_RHORTC3PLU6, NTPP_RICAEA8GQ13, NTPP_RICAH
A8GXY9, NTPP_RICB8Q1RK90, NTPP_RICBRA8F031, NTPP_RICCK
Q92G57, NTPP_RICCNQ4UJZ5, NTPP_RICFEQ9ZCE2, NTPP_RICPR
C4K258, NTPP_RICPUB0BVE4, NTPP_RICROA8GTV6, NTPP_RICRS
Q68VT4, NTPP_RICTYB7K400, NTPP_RIPO1Q16CZ1, NTPP_ROSDO
Q5LLN0, NTPP_RUEPOQ1GCM3, NTPP_RUESTA4FNQ1, NTPP_SACEN
A4X378, NTPP_SALTOQ83JE1, NTPP_SHIFLQ1GP76, NTPP_SPHAL
Q82I23, NTPP_STRAWQ9EWV6, NTPP_STRCOQ31RS8, NTPP_SYNE7
Q2JXB4, NTPP_SYNJAQ2JNH4, NTPP_SYNJBQ5N2H7, NTPP_SYNP6
A5GMB7, NTPP_SYNPWQ0IBR4, NTPP_SYNS3Q3AWW1, NTPP_SYNS9
Q3ALJ5, NTPP_SYNSCP74331, NTPP_SYNY3Q8DJC5, NTPP_THEVB
Q11A17, NTPP_TRIEIQ3MEX6, NTPP_TRIV2B2I858, NTPP_XYLF2
Q9PEA4, NTPP_XYLFAQ87EA3, NTPP_XYLFTQ5NRI7, NTPP_ZYMMO
Q9NV35, NUD15_HUMANQ8BG93, NUD15_MOUSEA7ZP69, NUDI_ECO24
B7UFR3, NUDI_ECO27B7MG18, NUDI_ECO45B7LAR6, NUDI_ECO55
Q8XE00, NUDI_ECO57B7NN72, NUDI_ECO7IB7MXT2, NUDI_ECO81
B7M5T3, NUDI_ECO8AC4ZU93, NUDI_ECOBWB1X8W4, NUDI_ECODH
A8A2B8, NUDI_ECOHSA1ADA3, NUDI_ECOK1Q0TFJ1, NUDI_ECOL5
Q8FFM5, NUDI_ECOL6B1IXT6, NUDI_ECOLCP52006, NUDI_ECOLI
B7N5L6, NUDI_ECOLUB6I7J4, NUDI_ECOSEB1LLK5, NUDI_ECOSM
Q1R9G4, NUDI_ECOUTA4WDK7, NUDI_ENT38B7LM80, NUDI_ESCF3
B5XNX5, NUDI_KLEP3A6TBV3, NUDI_KLEP7B5EZH4, NUDI_SALA4
A9MJC8, NUDI_SALARQ57M59, NUDI_SALCHB5FNT5, NUDI_SALDC
B5R268, NUDI_SALEPB5RCC0, NUDI_SALG2B4TBG2, NUDI_SALHS
B4SYW7, NUDI_SALNSQ5PC77, NUDI_SALPAA9N5B7, NUDI_SALPB
C0Q073, NUDI_SALPCB5BCQ0, NUDI_SALPKB4TPH8, NUDI_SALSV
Q8Z544, NUDI_SALTIQ8ZNF5, NUDI_SALTYQ0T2N2, NUDI_SHIF8
Q83KB9, NUDI_SHIFLQ3YZV5, NUDI_SHISS

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