Expasy logo

ENZYME

ENZYME entry: EC 3.6.1.9

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.9
Accepted Name
nucleotide diphosphatase
Alternative Name(s)
dinucleotide nucleotidohydrolase
nucleoside-triphosphate diphosphatase
nucleotide pyrophosphatase
Reaction catalysed
  • a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
  • a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
Comment(s)
  • The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates.
  • In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA.
  • Formerly EC 3.6.1.19.
Cross-references
BRENDA3.6.1.9
EC2PDB3.6.1.9
ExplorEnz3.6.1.9
KEGG Ligand Database for Enzyme Nomenclature3.6.1.9
IUBMB Enzyme Nomenclature3.6.1.9
MEDLINEFind literature relating to 3.6.1.9
MetaCyc3.6.1.9
Rhea expert-curated reactions3.6.1.9
UniProtKB/Swiss-Prot
O95671, ASML_HUMANA0A2L0V161, DGTPH_BPPMBA0A7U3TBV3, DGTPH_BPS2L
A0A2H5BHG5, DGTPH_BPSHAP22413, ENPP1_HUMANP06802, ENPP1_MOUSE
Q924C3, ENPP1_RATP15396, ENPP3_BOVINO14638, ENPP3_HUMAN
Q6DYE8, ENPP3_MOUSEQ5R5M5, ENPP3_PONABP97675, ENPP3_RAT
Q9X015, MAZG_THEMAD9YT79, NPP1_WHEATP25353, NPP1_YEAST
A0A3B6EFE3, NPP2_WHEATP39997, NPP2_YEASTQ8G4U8, NTPNH_BIFLO
Q28VZ8, NTPP1_JANSCQ28NC5, NTPP2_JANSCA3DBJ9, NTPPA_ACET2
A9NE14, NTPPA_ACHLIQ6FDX8, NTPPA_ACIADC4ZDP0, NTPPA_AGARV
Q8UHX5, NTPPA_AGRFCB2UPE6, NTPPA_AKKM8Q21WP7, NTPPA_ALBFT
Q0VS67, NTPPA_ALCBSQ5E7X6, NTPPA_ALIF1Q0ABM5, NTPPA_ALKEH
A6TQH7, NTPPA_ALKMQA8MHM5, NTPPA_ALKOOB8JH92, NTPPA_ANAD2
Q2IKU4, NTPPA_ANADEA7HA27, NTPPA_ANADFB4UJ23, NTPPA_ANASK
O67613, NTPPA_AQUAEQ5P2U3, NTPPA_AROAEC3P9E0, NTPPA_BACAA
C3L6Y6, NTPPA_BACACQ81LD6, NTPPA_BACANB7JQ48, NTPPA_BACC0
Q72ZX1, NTPPA_BACC1B7IIW6, NTPPA_BACC2C1ETQ1, NTPPA_BACC3
B7HE87, NTPPA_BACC4B7HQL2, NTPPA_BACC7A7GTD6, NTPPA_BACCN
B9IZ30, NTPPA_BACCQQ817R9, NTPPA_BACCRQ633Y9, NTPPA_BACCZ
Q5LAQ8, NTPPA_BACFNQ64R56, NTPPA_BACFRQ6HD71, NTPPA_BACHK
Q65GL2, NTPPA_BACLDA9VIS9, NTPPA_BACMKA8FFU1, NTPPA_BACP2
Q02169, NTPPA_BACSUQ8A749, NTPPA_BACTNA7Z794, NTPPA_BACVZ
Q6G253, NTPPA_BARHEQ6G132, NTPPA_BARQUQ6MQJ7, NTPPA_BDEBA
Q2KYV3, NTPPA_BORA1Q7WL84, NTPPA_BORBRQ7W7U4, NTPPA_BORPA
Q7VWE3, NTPPA_BORPEQ89V00, NTPPA_BRADUA5EAG4, NTPPA_BRASB
Q2YPC2, NTPPA_BRUA2Q57FA3, NTPPA_BRUABQ8YF55, NTPPA_BRUME
Q8G2R6, NTPPA_BRUSUQ39E95, NTPPA_BURL3Q62II4, NTPPA_BURMA
Q1BUW3, NTPPA_BURO1Q3JUG5, NTPPA_BURP1Q63VT5, NTPPA_BURPS
Q2SZT6, NTPPA_BURTAB9MRU6, NTPPA_CALBDQ8RBC6, NTPPA_CALS4
A4XKL5, NTPPA_CALS8Q3AF81, NTPPA_CARHZQ9A5V5, NTPPA_CAUVC
Q3J086, NTPPA_CERS4Q11LY4, NTPPA_CHESBQ5L6G5, NTPPA_CHLAB
Q3AQS4, NTPPA_CHLCHQ823U1, NTPPA_CHLCVQ253S7, NTPPA_CHLFF
Q3B3P0, NTPPA_CHLL3B3QNY9, NTPPA_CHLP8A4SE83, NTPPA_CHLPM
B0B7R8, NTPPA_CHLT2Q3KM09, NTPPA_CHLTAB0BBY3, NTPPA_CHLTB
Q8KDS1, NTPPA_CHLTEO84353, NTPPA_CHLTRA0M2D8, NTPPA_CHRFK
Q1QVC0, NTPPA_CHRI1Q7P1T8, NTPPA_CHRVOB5EHR3, NTPPA_CITBB
Q97JN3, NTPPA_CLOABA7FXW4, NTPPA_CLOB1C3L3L1, NTPPA_CLOB6
A6LQP7, NTPPA_CLOB8B2V089, NTPPA_CLOBAB2TK54, NTPPA_CLOBB
A5I684, NTPPA_CLOBHC1FVY3, NTPPA_CLOBJB1IM03, NTPPA_CLOBK
A7GHM0, NTPPA_CLOBLB1KZT1, NTPPA_CLOBMQ18B07, NTPPA_CLOD6
B9E003, NTPPA_CLOK1A5N6I4, NTPPA_CLOK5A0PZG3, NTPPA_CLONN
Q0TNG7, NTPPA_CLOP1Q8XIH4, NTPPA_CLOPEQ0SR36, NTPPA_CLOPS
Q892M0, NTPPA_CLOTEQ47VG7, NTPPA_COLP3Q1LQB1, NTPPA_CUPMC
Q46Y94, NTPPA_CUPPJQ11VI6, NTPPA_CYTH3Q47JQ0, NTPPA_DECAR
Q3Z7G4, NTPPA_DEHM1A5FQJ4, NTPPA_DEHMBQ3ZY38, NTPPA_DEHMC
Q1IYX1, NTPPA_DEIGDQ9RV24, NTPPA_DEIRAQ24SM2, NTPPA_DESHY
Q6AMI5, NTPPA_DESPSA4J7K7, NTPPA_DESRMB5YF11, NTPPA_DICT6
B8E0U2, NTPPA_DICTDP58629, NTPPA_ECO57Q0TCL8, NTPPA_ECOL5
Q8FD47, NTPPA_ECOL6P25536, NTPPA_ECOLIQ1R692, NTPPA_ECOUT
B2KC30, NTPPA_ELUMPQ82ZA4, NTPPA_ENTFAB1YJT1, NTPPA_EXIS2
A5FFP4, NTPPA_FLAJ1A6GZH5, NTPPA_FLAPJQ8RFE6, NTPPA_FUSNN
Q5KWN2, NTPPA_GEOKAQ39X87, NTPPA_GEOMGQ74A46, NTPPA_GEOSL
C6E559, NTPPA_GEOSMC5D5H8, NTPPA_GEOSWA5G7S1, NTPPA_GEOUR
Q7NH22, NTPPA_GLOVIQ5FS71, NTPPA_GLUOXQ0BTC5, NTPPA_GRABC
Q2SBH1, NTPPA_HAHCHQ9K8H3, NTPPA_HALH5Q31FH4, NTPPA_HYDCU
Q0C2H1, NTPPA_HYPNAQ5QWE2, NTPPA_IDILOQ1IV55, NTPPA_KORVE
B3W9W2, NTPPA_LACCBQ035Z4, NTPPA_LACP3A9KHL6, NTPPA_LACP7
Q38YR2, NTPPA_LATSSQ1MQH1, NTPPA_LAWIPB0S919, NTPPA_LEPBA
Q04NX0, NTPPA_LEPBJQ04XA6, NTPPA_LEPBLB0SK44, NTPPA_LEPBP
Q72WC1, NTPPA_LEPICQ8FA20, NTPPA_LEPINQ0AQL3, NTPPA_MARMM
Q8TSP7, NTPPA_METACQ46BZ6, NTPPA_METBFQ12TU6, NTPPA_METBU
Q60BT7, NTPPA_METCAQ1GZF7, NTPPA_METFKQ8PVQ2, NTPPA_METMA
Q2RL24, NTPPA_MOOTAQ1D912, NTPPA_MYXXDQ5FA52, NTPPA_NEIG1
Q9JVK3, NTPPA_NEIMAQ9K0J8, NTPPA_NEIMBQ82XC7, NTPPA_NITEU
Q1QRF9, NTPPA_NITHXQ2YC50, NTPPA_NITMUQ3J7T5, NTPPA_NITOC
Q72EP2, NTPPA_NITV2Q3SVZ7, NTPPA_NITWNQ2G9H1, NTPPA_NOVAD
Q315F5, NTPPA_OLEA2A6L8E5, NTPPA_PARD8Q2W1Y3, NTPPA_PARM1
Q6MDL5, NTPPA_PARUWQ142M3, NTPPA_PARXLQ9CLG6, NTPPA_PASMU
Q6DAI3, NTPPA_PECASB4SA80, NTPPA_PELPBA5D426, NTPPA_PELTS
Q7N035, NTPPA_PHOLLQ6LMA4, NTPPA_PHOPRA6L391, NTPPA_PHOV8
Q12C38, NTPPA_POLSJB2RIL9, NTPPA_PORG3Q7MWG0, NTPPA_PORGI
Q48E97, NTPPA_PSE14Q15ZH0, NTPPA_PSEA6Q9HVU3, NTPPA_PSEAE
Q4KIA3, NTPPA_PSEF5Q3KI22, NTPPA_PSEPFQ88PB4, NTPPA_PSEPK
Q87WS4, NTPPA_PSESMQ3IFH5, NTPPA_PSET1Q4ZNT2, NTPPA_PSEU2
Q4FUF9, NTPPA_PSYA2Q1QDI9, NTPPA_PSYCKQ9UXZ1, NTPPA_PYRAB
Q8U476, NTPPA_PYRFUO59604, NTPPA_PYRHOP58634, NTPPA_RALN1
Q2KCN4, NTPPA_RHIECQ1MLP2, NTPPA_RHIJ3Q989F1, NTPPA_RHILO
Q92S22, NTPPA_RHIMEQ7UWY8, NTPPA_RHOBAQ2IRX7, NTPPA_RHOP2
Q6N181, NTPPA_RHOPAQ20Y49, NTPPA_RHOPBQ130J6, NTPPA_RHOPS
Q2RQN0, NTPPA_RHORTQ169N3, NTPPA_ROSDOQ1AVT5, NTPPA_RUBXD
Q5LLE9, NTPPA_RUEPOQ1GLE1, NTPPA_RUESTB8I6Q1, NTPPA_RUMCH
Q21FT3, NTPPA_SACD2Q57J97, NTPPA_SALCHQ5PJV0, NTPPA_SALPA
Q2S4I1, NTPPA_SALRDP58631, NTPPA_SALTIP58630, NTPPA_SALTY
O14141, NTPPA_SCHPOQ12IW9, NTPPA_SHEDOQ07WQ2, NTPPA_SHEFN
Q8EA14, NTPPA_SHEONQ0HEI2, NTPPA_SHESMQ0HZH0, NTPPA_SHESR
Q31WB6, NTPPA_SHIBSQ32B92, NTPPA_SHIDSQ3YX01, NTPPA_SHISS
Q5WEQ9, NTPPA_SHOC1Q1GRU5, NTPPA_SPHALA3DMH6, NTPPA_STAMF
Q67SI8, NTPPA_SYMTHQ2LSD6, NTPPA_SYNASQ3A7I0, NTPPA_SYNC1
Q0AWG2, NTPPA_SYNWWB7IFS5, NTPPA_THEABC5A216, NTPPA_THEGJ
Q5JI98, NTPPA_THEKOA6LJI7, NTPPA_THEM4Q9X1P2, NTPPA_THEMA
B6YWV3, NTPPA_THEONA5IM27, NTPPA_THEP1B0KAE1, NTPPA_THEP3
B0K437, NTPPA_THEPXB9KXM8, NTPPA_THERPB1LB65, NTPPA_THESQ
Q72JE7, NTPPA_THET2Q5SJ26, NTPPA_THET8Q3SG65, NTPPA_THIDA
Q73K74, NTPPA_TREDEQ9KUU7, NTPPA_VIBCHQ87LC4, NTPPA_VIBPA
Q8DCG8, NTPPA_VIBVUQ7MHE0, NTPPA_VIBVYQ73I47, NTPPA_WOLPM
B3CL80, NTPPA_WOLPPQ5GT91, NTPPA_WOLTRC0R2U8, NTPPA_WOLWR
Q8PIX4, NTPPA_XANACQ4UWJ9, NTPPA_XANC8Q8P7K1, NTPPA_XANCP
Q3BRF4, NTPPA_XANE5Q2P0P1, NTPPA_XANOMQ5GXK1, NTPPA_XANOR
Q99210, NTPPA_YEASTQ1C1M9, NTPPA_YERPAP58636, NTPPA_YERPE
Q1CDV0, NTPPA_YERPNQ665F6, NTPPA_YERPSQ5NNS3, NTPPA_ZYMMO
B0C1T2, NTPP_ACAM1Q6FB05, NTPP_ACIADQ8UJC6, NTPP_AGRFC
B9KIX1, NTPP_ANAMFQ5PAF5, NTPP_ANAMMQ2GKV0, NTPP_ANAPZ
Q89WP0, NTPP_BRADUA8FKT3, NTPP_CAMJ8A7H4N2, NTPP_CAMJD
Q9PI04, NTPP_CAMJEA1VYL9, NTPP_CAMJJQ5HVQ6, NTPP_CAMJR
Q9AC58, NTPP_CAUVCQ3IYH0, NTPP_CERS4Q9PK45, NTPP_CHLMU
Q9Z9F9, NTPP_CHLPNC3PEA3, NTPP_CORA7Q6NIW2, NTPP_CORDI
Q8FRM5, NTPP_COREFA4QC50, NTPP_CORGBQ8NSH0, NTPP_CORGL
Q4JTL6, NTPP_CORJKQ6A725, NTPP_CUTAKB8HN65, NTPP_CYAP4
B1I4S1, NTPP_DESAPQ55G28, NTPP_DICDIQ3YRV1, NTPP_EHRCJ
Q2GGV6, NTPP_EHRCRQ5FGZ7, NTPP_EHRRGQ5HB21, NTPP_EHRRW
Q2GCP9, NTPP_EHRS3B7KJY0, NTPP_GLOC7Q5FS37, NTPP_GLUOX
Q0BWA0, NTPP_GRABCQ7VKR7, NTPP_HAEDUB6JN80, NTPP_HELP2
B5Z8N5, NTPP_HELPGQ1CS23, NTPP_HELPHQ9ZJY6, NTPP_HELPJ
B2UV03, NTPP_HELPSO25838, NTPP_HELPYQ0C6A7, NTPP_HYPNA
Q5X3L5, NTPP_LEGPAA5IDM1, NTPP_LEGPCQ5ZTX2, NTPP_LEGPH
Q5WV03, NTPP_LEGPLQ6AGN3, NTPP_LEIXXQ0AKD7, NTPP_MARMM
B0JH94, NTPP_MICANQ7TWT7, NTPP_MYCBOA1KNT4, NTPP_MYCBP
C1AH56, NTPP_MYCBTA4TF31, NTPP_MYCGIB8ZUX8, NTPP_MYCLB
Q49670, NTPP_MYCLEB2HEK5, NTPP_MYCMMQ73UG7, NTPP_MYCPA
A0QTE5, NTPP_MYCS2A3PW53, NTPP_MYCSJA1UCG3, NTPP_MYCSK
Q1BCI0, NTPP_MYCSSA5U7V6, NTPP_MYCTAP9WK26, NTPP_MYCTO
P9WK27, NTPP_MYCTUA0PRJ3, NTPP_MYCUAA1T5Q3, NTPP_MYCVP
Q1DAV2, NTPP_MYXXDQ1QRY3, NTPP_NITHXA6Q573, NTPP_NITSB
Q3SWH0, NTPP_NITWNQ5Z154, NTPP_NOCFAB2J6P8, NTPP_NOSP7
P58632, NTPP_NOSS1Q2GC58, NTPP_NOVADA5CCC1, NTPP_ORITB
Q2VYH3, NTPP_PARM1Q7U5K1, NTPP_PARMWQ4FNS4, NTPP_PELUB
A3PDZ9, NTPP_PROM0A2C3V6, NTPP_PROM1A8G5U9, NTPP_PROM2
A2C7X9, NTPP_PROM3Q319X8, NTPP_PROM9Q7VB43, NTPP_PROMA
Q7V6H8, NTPP_PROMMQ7V0U3, NTPP_PROMPA2BS59, NTPP_PROMS
Q46JR8, NTPP_PROMTC0ZWV2, NTPP_RHOE4Q0S319, NTPP_RHOJR
C1B1A6, NTPP_RHOOBQ2J353, NTPP_RHOP2Q6ND10, NTPP_RHOPA
Q21CL6, NTPP_RHOPBQ13E26, NTPP_RHOPSQ2RN87, NTPP_RHORT
C3PLU6, NTPP_RICAEA8GQ13, NTPP_RICAHA8GXY9, NTPP_RICB8
Q1RK90, NTPP_RICBRA8F031, NTPP_RICCKQ92G57, NTPP_RICCN
Q4UJZ5, NTPP_RICFEQ9ZCE2, NTPP_RICPRC4K258, NTPP_RICPU
B0BVE4, NTPP_RICROA8GTV6, NTPP_RICRSQ68VT4, NTPP_RICTY
B7K400, NTPP_RIPO1Q16CZ1, NTPP_ROSDOQ5LLN0, NTPP_RUEPO
Q1GCM3, NTPP_RUESTA4FNQ1, NTPP_SACENA4X378, NTPP_SALTO
Q83JE1, NTPP_SHIFLQ1GP76, NTPP_SPHALQ82I23, NTPP_STRAW
Q9EWV6, NTPP_STRCOQ31RS8, NTPP_SYNE7Q2JXB4, NTPP_SYNJA
Q2JNH4, NTPP_SYNJBQ5N2H7, NTPP_SYNP6A5GMB7, NTPP_SYNPW
Q0IBR4, NTPP_SYNS3Q3AWW1, NTPP_SYNS9Q3ALJ5, NTPP_SYNSC
P74331, NTPP_SYNY3Q8DJC5, NTPP_THEVBQ11A17, NTPP_TRIEI
Q3MEX6, NTPP_TRIV2B2I858, NTPP_XYLF2Q9PEA4, NTPP_XYLFA
Q87EA3, NTPP_XYLFTQ5NRI7, NTPP_ZYMMOQ9NV35, NUD15_HUMAN
Q8BG93, NUD15_MOUSEA7ZP69, NUDI_ECO24B7UFR3, NUDI_ECO27
B7MG18, NUDI_ECO45B7LAR6, NUDI_ECO55Q8XE00, NUDI_ECO57
B7NN72, NUDI_ECO7IB7MXT2, NUDI_ECO81B7M5T3, NUDI_ECO8A
C4ZU93, NUDI_ECOBWB1X8W4, NUDI_ECODHA8A2B8, NUDI_ECOHS
A1ADA3, NUDI_ECOK1Q0TFJ1, NUDI_ECOL5Q8FFM5, NUDI_ECOL6
B1IXT6, NUDI_ECOLCP52006, NUDI_ECOLIB7N5L6, NUDI_ECOLU
B6I7J4, NUDI_ECOSEB1LLK5, NUDI_ECOSMQ1R9G4, NUDI_ECOUT
A4WDK7, NUDI_ENT38B7LM80, NUDI_ESCF3A6TBV3, NUDI_KLEP7
B5XNX5, NUDI_KLEV3B5EZH4, NUDI_SALA4A9MJC8, NUDI_SALAR
Q57M59, NUDI_SALCHB5FNT5, NUDI_SALDCB5R268, NUDI_SALEP
B5RCC0, NUDI_SALG2B4TBG2, NUDI_SALHSB4SYW7, NUDI_SALNS
Q5PC77, NUDI_SALPAA9N5B7, NUDI_SALPBC0Q073, NUDI_SALPC
B5BCQ0, NUDI_SALPKB4TPH8, NUDI_SALSVQ8Z544, NUDI_SALTI
Q8ZNF5, NUDI_SALTYQ0T2N2, NUDI_SHIF8Q83KB9, NUDI_SHIFL
Q3YZV5, NUDI_SHISS

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-