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ENZYME entry: EC 3.6.5.2

Accepted Name
Small monomeric GTPase.
Reaction catalysed
GTP + H(2)O <=> GDP + phosphate
Comment(s)
  • A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of EC 3.6.1.46.
  • Involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
  • Formerly EC 3.6.1.47.
Cross-references
PROSITEPDOC00859
BRENDA3.6.5.2
EC2PDB3.6.5.2
ExplorEnz3.6.5.2
PRIAM enzyme-specific profiles3.6.5.2
KEGG Ligand Database for Enzyme Nomenclature3.6.5.2
IUBMB Enzyme Nomenclature3.6.5.2
IntEnz3.6.5.2
MEDLINEFind literature relating to 3.6.5.2
MetaCyc3.6.5.2
UniProtKB/Swiss-Prot
Q2KJ93, CDC42_BOVIN;  P60952, CDC42_CANLF;  Q90694, CDC42_CHICK;  
P40793, CDC42_DROME;  Q29HY3, CDC42_DROPS;  P60953, CDC42_HUMAN;  
Q4R4R6, CDC42_MACFA;  P60766, CDC42_MOUSE;  Q007T2, CDC42_PIG;  
Q8CFN2, CDC42_RAT;  Q94CF0, EHD1_ARATH;  B3LF48, EHD2_ARATH;  
Q0IIG7, RAB5A_BOVIN;  P18066, RAB5A_CANLF;  P20339, RAB5A_HUMAN;  
P61271, RAB5A_MACFA;  Q9CQD1, RAB5A_MOUSE;  Q06AU6, RAB5A_PIG;  
M0RC99, RAB5A_RAT;  P62998, RAC1_BOVIN;  P62999, RAC1_CANLF;  
P80236, RAC1_CAVPO;  P63000, RAC1_HUMAN;  P63001, RAC1_MOUSE;  
Q6RUV5, RAC1_RAT;  P60763, RAC3_HUMAN;  P60764, RAC3_MOUSE;  
Q1HE58, RB27A_CANLF;  P51159, RB27A_HUMAN;  Q9ERI2, RB27A_MOUSE;  
Q4LE85, RB27A_PIG;  P23640, RB27A_RAT;  Q8HZJ5, RB27B_BOVIN;  
O00194, RB27B_HUMAN;  Q99P58, RB27B_MOUSE;  Q99P74, RB27B_RAT;  
P61585, RHOA_BOVIN;  P24406, RHOA_CANLF;  P61586, RHOA_HUMAN;  
Q9QUI0, RHOA_MOUSE;  Q5REY6, RHOA_PONAB;  P61589, RHOA_RAT;  

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