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ENZYME entry: EC 3.6.5.2

Accepted Name
Small monomeric GTPase.
Reaction catalysed
GTP + H(2)O <=> GDP + phosphate
Comment(s)
  • A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of EC 3.6.1.46.
  • Involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
  • Formerly EC 3.6.1.47.
Cross-references
PROSITEPDOC00859
BRENDA3.6.5.2
EC2PDB3.6.5.2
ExplorEnz3.6.5.2
PRIAM enzyme-specific profiles3.6.5.2
KEGG Ligand Database for Enzyme Nomenclature3.6.5.2
IUBMB Enzyme Nomenclature3.6.5.2
IntEnz3.6.5.2
MEDLINEFind literature relating to 3.6.5.2
MetaCyc3.6.5.2
UniProtKB/Swiss-Prot
Q2KJ93, CDC42_BOVIN;  P60952, CDC42_CANLF;  Q90694, CDC42_CHICK;  
P40793, CDC42_DROME;  Q29HY3, CDC42_DROPS;  P60953, CDC42_HUMAN;  
Q4R4R6, CDC42_MACFA;  P60766, CDC42_MOUSE;  Q007T2, CDC42_PIG;  
Q8CFN2, CDC42_RAT;  Q94CF0, EHD1_ARATH;  B3LF48, EHD2_ARATH;  
Q94148, RAB10_CAEEL;  P24409, RAB10_CANLF;  Q5ZIT5, RAB10_CHICK;  
P61026, RAB10_HUMAN;  P61027, RAB10_MOUSE;  Q5R5U1, RAB10_PONAB;  
P35281, RAB10_RAT;  Q2TBH7, RAB4A_BOVIN;  Q6PHI9, RAB4A_DANRE;  
P20338, RAB4A_HUMAN;  P56371, RAB4A_MOUSE;  P05714, RAB4A_RAT;  
P61017, RAB4B_CANLF;  Q68EK7, RAB4B_DANRE;  P61018, RAB4B_HUMAN;  
Q91ZR1, RAB4B_MOUSE;  P51146, RAB4B_RAT;  Q0IIG7, RAB5A_BOVIN;  
P18066, RAB5A_CANLF;  P20339, RAB5A_HUMAN;  P61271, RAB5A_MACFA;  
Q9CQD1, RAB5A_MOUSE;  Q06AU6, RAB5A_PIG;  M0RC99, RAB5A_RAT;  
Q3T0F5, RAB7A_BOVIN;  P18067, RAB7A_CANLF;  P36411, RAB7A_DICDI;  
P51149, RAB7A_HUMAN;  P51150, RAB7A_MOUSE;  Q95UJ0, RAB7A_PAROT;  
Q5R9Y4, RAB7A_PONAB;  O97572, RAB7A_RABIT;  P09527, RAB7A_RAT;  
P62998, RAC1_BOVIN;  P62999, RAC1_CANLF;  P80236, RAC1_CAVPO;  
P63000, RAC1_HUMAN;  P63001, RAC1_MOUSE;  Q6RUV5, RAC1_RAT;  
P60763, RAC3_HUMAN;  P60764, RAC3_MOUSE;  P48555, RALA_DROME;  
P11233, RALA_HUMAN;  P63321, RALA_MOUSE;  P63322, RALA_RAT;  
P63320, RALA_SAGOE;  Q9YH09, RALBA_XENLA;  Q6IP71, RALBB_XENLA;  
P11234, RALB_HUMAN;  Q4R379, RALB_MACFA;  Q9JIW9, RALB_MOUSE;  
Q5R4B8, RALB_PONAB;  P36860, RALB_RAT;  P22124, RAL_DIPOM;  
P62833, RAP1A_BOVIN;  P62834, RAP1A_HUMAN;  P62835, RAP1A_MOUSE;  
P62836, RAP1A_RAT;  P61223, RAP1B_BOVIN;  Q5ZHX1, RAP1B_CHICK;  
Q9YH37, RAP1B_CYPCA;  Q6TEN1, RAP1B_DANRE;  P61224, RAP1B_HUMAN;  
Q4R9D4, RAP1B_MACFA;  Q99JI6, RAP1B_MOUSE;  A5A6J7, RAP1B_PANTR;  
Q5RDM6, RAP1B_PONAB;  Q62636, RAP1B_RAT;  Q7ZXH7, RAP1B_XENLA;  
Q640R7, RAP1B_XENTR;  Q18246, RAP1_CAEEL;  P08645, RAP1_DROME;  
Q94694, RAP1_PHYPO;  P10114, RAP2A_HUMAN;  Q80ZJ1, RAP2A_MOUSE;  
Q06AU2, RAP2A_PIG;  Q5R988, RAP2A_PONAB;  P61225, RAP2B_HUMAN;  
P61226, RAP2B_MOUSE;  P61227, RAP2B_RAT;  Q08DI5, RAP2C_BOVIN;  
Q9Y3L5, RAP2C_HUMAN;  Q8BU31, RAP2C_MOUSE;  P18613, RAPA_DICDI;  
P22123, RAPA_DIPOM;  Q86L51, RAPB_DICDI;  Q55BW0, RAPC_DICDI;  
C4YKT4, RAS1_CANAW;  P0CY32, RAS1_CANAX;  B3M185, RAS1_DROAN;  
B3NZR4, RAS1_DROER;  B4JFU8, RAS1_DROGR;  P83832, RAS1_DROMA;  
P08646, RAS1_DROME;  B4KB60, RAS1_DROMO;  B4GFJ8, RAS1_DROPE;  
Q295X7, RAS1_DROPS;  B4HKC7, RAS1_DROSE;  P83831, RAS1_DROSI;  
B4LY29, RAS1_DROVI;  B4NJ72, RAS1_DROWI;  B4PUP5, RAS1_DROYA;  
P51539, RAS1_HYDVU;  P22278, RAS1_MUCCL;  P22126, RAS1_NEUCR;  
P34729, RAS1_PHYPO;  P01119, RAS1_YEAST;  P04388, RAS2_DROME;  
P38976, RAS2_HYDVU;  P22279, RAS2_MUCCL;  Q01387, RAS2_NEUCR;  
P34726, RAS2_PHYPO;  P01120, RAS2_YEAST;  P22280, RAS3_MUCCL;  
P32252, RASB_DICDI;  P32253, RASC_DICDI;  P03967, RASD_DICDI;  
Q7Z444, RASE_HUMAN;  Q7TN89, RASE_MOUSE;  P15064, RASG_DICDI;  
P08642, RASH_CHICK;  P01112, RASH_HUMAN;  Q60529, RASH_MESAU;  
Q61411, RASH_MOUSE;  P01115, RASH_MSVHA;  P01113, RASH_MSVMO;  
P23175, RASH_MSVNS;  P20171, RASH_RAT;  P01114, RASH_RRASV;  
Q9YH38, RASK_CYPCA;  P01116, RASK_HUMAN;  Q5EFX7, RASK_KRYMA;  
P79800, RASK_MELGA;  Q07983, RASK_MONDO;  P32883, RASK_MOUSE;  
P01117, RASK_MSVKI;  O42277, RASK_ORYLA;  P08644, RASK_RAT;  
Q05147, RASK_XENLA;  Q08E00, RASLC_BOVIN;  Q7SZ59, RASLC_DANRE;  
Q9NYN1, RASLC_HUMAN;  Q08AT1, RASLC_MOUSE;  O42785, RASL_COLTR;  
A8NU18, RASL_COPC7;  Q05058, RASL_COPCI;  O14807, RASM_HUMAN;  
O08989, RASM_MOUSE;  P97538, RASM_RAT;  P12825, RASN_CAVPO;  
Q5F352, RASN_CHICK;  P79737, RASN_DANRE;  P01111, RASN_HUMAN;  
Q95ME4, RASN_MONDO;  P08556, RASN_MOUSE;  Q2MJK3, RASN_PIG;  
Q5RD87, RASN_PONAB;  Q04970, RASN_RAT;  Q91806, RASN_XENLA;  
P32254, RASS_DICDI;  Q55CB0, RASU_DICDI;  Q55CB9, RASV_DICDI;  
Q55CC0, RASW_DICDI;  Q55CB8, RASX_DICDI;  Q55CB7, RASY_DICDI;  
Q55CA9, RASZ_DICDI;  P18262, RAS_ARTSA;  P87018, RAS_BOTFU;  
P05774, RAS_CARAU;  P0CQ43, RAS_CRYNB;  P0CQ42, RAS_CRYNJ;  
Q12526, RAS_EMENI;  P24498, RAS_GEOCY;  O93856, RAS_LACBI;  
P28775, RAS_LENED;  Q91079, RAS_LIMLI;  P08647, RAS_SCHPO;  
Q1HE58, RB27A_CANLF;  P51159, RB27A_HUMAN;  Q9ERI2, RB27A_MOUSE;  
Q4LE85, RB27A_PIG;  P23640, RB27A_RAT;  Q8HZJ5, RB27B_BOVIN;  
O00194, RB27B_HUMAN;  Q99P58, RB27B_MOUSE;  Q99P74, RB27B_RAT;  
A6QP66, RERGL_BOVIN;  Q6DGN0, RERGL_DANRE;  Q9H628, RERGL_HUMAN;  
Q0VCJ7, RERG_BOVIN;  Q96A58, RERG_HUMAN;  Q8R367, RERG_MOUSE;  
P61585, RHOA_BOVIN;  P24406, RHOA_CANLF;  P61586, RHOA_HUMAN;  
Q9QUI0, RHOA_MOUSE;  Q5REY6, RHOA_PONAB;  P61589, RHOA_RAT;  
Q92963, RIT1_HUMAN;  P70426, RIT1_MOUSE;  Q99578, RIT2_HUMAN;  
P70425, RIT2_MOUSE;  Q5BJQ5, RIT2_RAT;  Q92737, RSLAA_HUMAN;  
Q8K5A4, RSLAA_MOUSE;  Q96S79, RSLAB_HUMAN;  Q5SSG5, RSLAB_MOUSE;  
Q6T310, RSLBA_HUMAN;  Q6IMB1, RSLBA_MOUSE;  Q6IMA3, RSLBA_RAT;  
Q5E9J3, RSLBB_BOVIN;  Q6P0U3, RSLBB_DANRE;  Q9BPW5, RSLBB_HUMAN;  
Q922H7, RSLBB_MOUSE;  Q6IMA7, RSLBB_RAT;  Q8AVS6, RSLBB_XENLA;  
Q5FVY2, RSLBB_XENTR;  A1DZY4, RSLBL_DANRE;  P52498, RSR1_CANAX;  
P13856, RSR1_YEAST;  

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