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ENZYME

ENZYME entry: EC 3.6.5.2

Accepted Name
small monomeric GTPase
Reaction catalysed
GTP + H2O = GDP + H(+) + phosphate
Comment(s)
  • A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of EC 3.6.1.46.
  • Involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
  • Formerly EC 3.6.1.47.
Cross-references
BRENDA3.6.5.2
EC2PDB3.6.5.2
ExplorEnz3.6.5.2
PRIAM enzyme-specific profiles3.6.5.2
KEGG Ligand Database for Enzyme Nomenclature3.6.5.2
IUBMB Enzyme Nomenclature3.6.5.2
IntEnz3.6.5.2
MEDLINEFind literature relating to 3.6.5.2
MetaCyc3.6.5.2
Rhea expert-curated reactions3.6.5.2
UniProtKB/Swiss-Prot
Q94231, ARF11_CAEELQ61LA8, ARF12_CAEBRQ10943, ARF12_CAEEL
P36397, ARF1_ARATHP84080, ARF1_BOVINQ96361, ARF1_BRARP
O23778, ARF1_CATROP51821, ARF1_CHLREP51822, ARF1_DAUCA
O00909, ARF1_DICDIP61209, ARF1_DROMEP84077, ARF1_HUMAN
P61210, ARF1_LOCMIQ4R5P2, ARF1_MACFAP84078, ARF1_MOUSE
Q06396, ARF1_ORYSJQ7KQL3, ARF1_PLAF7Q94650, ARF1_PLAFA
Q25761, ARF1_PLAFOP84079, ARF1_RATO48649, ARF1_SALBA
P36579, ARF1_SCHPOP51824, ARF1_SOLTUP51643, ARF1_XENLA
P11076, ARF1_YEASTP26990, ARF6_CHICKP62330, ARF6_HUMAN
P62331, ARF6_MOUSEQ007T5, ARF6_PIGP62332, ARF6_RAT
P51645, ARF6_XENLAQ2KI07, ARL8B_BOVINQ9NVJ2, ARL8B_HUMAN
Q4R4S4, ARL8B_MACFAQ9CQW2, ARL8B_MOUSEQ5R6E7, ARL8B_PONAB
Q66HA6, ARL8B_RATQ2KJ93, CDC42_BOVINP60952, CDC42_CANLF
Q90694, CDC42_CHICKP40793, CDC42_DROMEQ29HY3, CDC42_DROPS
P60953, CDC42_HUMANQ4R4R6, CDC42_MACFAP60766, CDC42_MOUSE
Q007T2, CDC42_PIGQ8CFN2, CDC42_RATP19073, CDC42_YEAST
Q94CF0, EHD1_ARATHB3LF48, EHD2_ARATHQ94148, RAB10_CAEEL
P24409, RAB10_CANLFQ5ZIT5, RAB10_CHICKP61026, RAB10_HUMAN
P61027, RAB10_MOUSEQ5R5U1, RAB10_PONABP35281, RAB10_RAT
Q5ZKU5, RAB14_CHICKP36410, RAB14_DICDIP61106, RAB14_HUMAN
Q91V41, RAB14_MOUSEQ52NJ6, RAB14_PIGQ5R8Z8, RAB14_PONAB
P61107, RAB14_RATP62822, RAB1A_CANLFP62820, RAB1A_HUMAN
P62821, RAB1A_MOUSEQ52NJ2, RAB1A_PIGQ6NYB7, RAB1A_RAT
Q2HJH2, RAB1B_BOVINQ9H0U4, RAB1B_HUMANQ4R8X3, RAB1B_MACFA
Q9D1G1, RAB1B_MOUSEQ06AU7, RAB1B_PIGQ5RE13, RAB1B_PONAB
P10536, RAB1B_RATQ92928, RAB1C_HUMANP61105, RAB2A_CANLF
Q90965, RAB2A_CHICKP36409, RAB2A_DICDIP61019, RAB2A_HUMAN
Q4R4X6, RAB2A_MACFAP86207, RAB2A_MESAUP53994, RAB2A_MOUSE
Q5R6B6, RAB2A_PONABQ01971, RAB2A_RABITP05712, RAB2A_RAT
Q8WUD1, RAB2B_HUMANP59279, RAB2B_MOUSEO18333, RAB2_DROME
Q2TBH7, RAB4A_BOVINQ6PHI9, RAB4A_DANREP20338, RAB4A_HUMAN
P56371, RAB4A_MOUSEP05714, RAB4A_RATP61017, RAB4B_CANLF
Q68EK7, RAB4B_DANREP61018, RAB4B_HUMANQ91ZR1, RAB4B_MOUSE
P51146, RAB4B_RATQ0IIG7, RAB5A_BOVINP18066, RAB5A_CANLF
P20339, RAB5A_HUMANP61271, RAB5A_MACFAQ9CQD1, RAB5A_MOUSE
Q06AU6, RAB5A_PIGM0RC99, RAB5A_RATQ5ZHW4, RAB5B_CHICK
P61020, RAB5B_HUMANP61021, RAB5B_MOUSEQ76NM7, RAB5B_PLAF7
Q5RBG1, RAB5B_PONABQ58DS9, RAB5C_BOVINP51147, RAB5C_CANLF
Q98932, RAB5C_CHICKP51148, RAB5C_HUMANP35278, RAB5C_MOUSE
Q5R7L7, RAB5C_PONABQ9V3I2, RAB5_DROMEA6QR46, RAB6B_BOVIN
Q9NRW1, RAB6B_HUMANP61294, RAB6B_MOUSEQ3T0F5, RAB7A_BOVIN
P18067, RAB7A_CANLFP36411, RAB7A_DICDIP51149, RAB7A_HUMAN
P51150, RAB7A_MOUSEQ95UJ0, RAB7A_PAROTQ5R9Y4, RAB7A_PONAB
O97572, RAB7A_RABITP09527, RAB7A_RATO76742, RAB7_DROME
A4FV54, RAB8A_BOVINP61007, RAB8A_CANLFQ5F470, RAB8A_CHICK
P61006, RAB8A_HUMANQ4R5P1, RAB8A_MACFAP55258, RAB8A_MOUSE
Q5R4A3, RAB8A_PONABP35280, RAB8A_RATP62998, RAC1_BOVIN
P62999, RAC1_CANLFP80236, RAC1_CAVPOP63000, RAC1_HUMAN
P63001, RAC1_MOUSEQ6RUV5, RAC1_RATP60763, RAC3_HUMAN
P60764, RAC3_MOUSEQ24814, RACA_ENTH1Q24815, RACB_ENTH1
Q24816, RACC_ENTH1Q24817, RACD_ENTH1O76321, RACG_ENTH1
P48555, RALA_DROMEP11233, RALA_HUMANP63321, RALA_MOUSE
P63322, RALA_RATP63320, RALA_SAGOEQ9YH09, RALBA_XENLA
Q6IP71, RALBB_XENLAP11234, RALB_HUMANQ4R379, RALB_MACFA
Q9JIW9, RALB_MOUSEQ5R4B8, RALB_PONABP36860, RALB_RAT
P22124, RAL_DIPOMP62833, RAP1A_BOVINP62834, RAP1A_HUMAN
P62835, RAP1A_MOUSEP62836, RAP1A_RATP61223, RAP1B_BOVIN
Q5ZHX1, RAP1B_CHICKQ9YH37, RAP1B_CYPCAQ6TEN1, RAP1B_DANRE
P61224, RAP1B_HUMANQ4R9D4, RAP1B_MACFAQ99JI6, RAP1B_MOUSE
A5A6J7, RAP1B_PANTRQ5RDM6, RAP1B_PONABQ62636, RAP1B_RAT
Q7ZXH7, RAP1B_XENLAQ640R7, RAP1B_XENTRQ18246, RAP1_CAEEL
P08645, RAP1_DROMEQ94694, RAP1_PHYPOP10114, RAP2A_HUMAN
Q80ZJ1, RAP2A_MOUSEQ06AU2, RAP2A_PIGQ5R988, RAP2A_PONAB
P61225, RAP2B_HUMANP61226, RAP2B_MOUSEP61227, RAP2B_RAT
Q08DI5, RAP2C_BOVINQ9Y3L5, RAP2C_HUMANQ8BU31, RAP2C_MOUSE
P18613, RAPA_DICDIP22123, RAPA_DIPOMQ86L51, RAPB_DICDI
Q55BW0, RAPC_DICDIC4YKT4, RAS1_CANAWP0CY32, RAS1_CANAX
B3M185, RAS1_DROANB3NZR4, RAS1_DROERB4JFU8, RAS1_DROGR
P83832, RAS1_DROMAP08646, RAS1_DROMEB4KB60, RAS1_DROMO
B4GFJ8, RAS1_DROPEQ295X7, RAS1_DROPSB4HKC7, RAS1_DROSE
P83831, RAS1_DROSIB4LY29, RAS1_DROVIB4NJ72, RAS1_DROWI
B4PUP5, RAS1_DROYAP51539, RAS1_HYDVUP22278, RAS1_MUCCL
P22126, RAS1_NEUCRP34729, RAS1_PHYPOP01119, RAS1_YEAST
P04388, RAS2_DROMEP38976, RAS2_HYDVUP22279, RAS2_MUCCL
Q01387, RAS2_NEUCRP34726, RAS2_PHYPOP01120, RAS2_YEAST
P22280, RAS3_MUCCLQ4X241, RASB_ASPFUP32252, RASB_DICDI
P32253, RASC_DICDIP03967, RASD_DICDIQ7Z444, RASE_HUMAN
Q7TN89, RASE_MOUSEP15064, RASG_DICDIP08642, RASH_CHICK
P01112, RASH_HUMANQ60529, RASH_MESAUQ61411, RASH_MOUSE
P01115, RASH_MSVHAP01113, RASH_MSVMOP23175, RASH_MSVNS
P20171, RASH_RATP01114, RASH_RRASVQ9YH38, RASK_CYPCA
P01116, RASK_HUMANQ5EFX7, RASK_KRYMAP79800, RASK_MELGA
Q07983, RASK_MONDOP32883, RASK_MOUSEP01117, RASK_MSVKI
O42277, RASK_ORYLAP08644, RASK_RATQ05147, RASK_XENLA
Q08E00, RASLC_BOVINQ7SZ59, RASLC_DANREQ9NYN1, RASLC_HUMAN
Q08AT1, RASLC_MOUSEO42785, RASL_COLTRA8NU18, RASL_COPC7
Q05058, RASL_COPCIO14807, RASM_HUMANO08989, RASM_MOUSE
P97538, RASM_RATP12825, RASN_CAVPOQ5F352, RASN_CHICK
P79737, RASN_DANREP01111, RASN_HUMANQ95ME4, RASN_MONDO
P08556, RASN_MOUSEQ2MJK3, RASN_PIGQ5RD87, RASN_PONAB
Q04970, RASN_RATQ91806, RASN_XENLAP32254, RASS_DICDI
Q55CB0, RASU_DICDIQ55CB9, RASV_DICDIQ55CC0, RASW_DICDI
Q55CB8, RASX_DICDIQ55CB7, RASY_DICDIQ55CA9, RASZ_DICDI
P18262, RAS_ARTSAP87018, RAS_BOTFUP05774, RAS_CARAU
P0CQ43, RAS_CRYNBP0CQ42, RAS_CRYNJQ12526, RAS_EMENI
P24498, RAS_GEOCYO93856, RAS_LACBIP28775, RAS_LENED
Q91079, RAS_LIMLIP08647, RAS_SCHPOQ2TA29, RB11A_BOVIN
P62490, RB11A_CANLFQ5ZJN2, RB11A_CHICKP62491, RB11A_HUMAN
P62492, RB11A_MOUSEQ52NJ1, RB11A_PIGQ5R9M7, RB11A_PONAB
P62493, RB11A_RABITP62494, RB11A_RATQ3MHP2, RB11B_BOVIN
Q15907, RB11B_HUMANP46638, RB11B_MOUSEO35509, RB11B_RAT
Q1HE58, RB27A_CANLFP51159, RB27A_HUMANQ9ERI2, RB27A_MOUSE
Q4LE85, RB27A_PIGP23640, RB27A_RATQ8HZJ5, RB27B_BOVIN
O00194, RB27B_HUMANQ99P58, RB27B_MOUSEQ99P74, RB27B_RAT
A6QP66, RERGL_BOVINQ6DGN0, RERGL_DANREQ9H628, RERGL_HUMAN
Q0VCJ7, RERG_BOVINQ96A58, RERG_HUMANQ8R367, RERG_MOUSE
P31021, RHO1_ENTH1P06780, RHO1_YEASTP06781, RHO2_YEAST
Q00246, RHO4_YEASTP61585, RHOA_BOVINP24406, RHOA_CANLF
P61586, RHOA_HUMANQ9QUI0, RHOA_MOUSEQ5REY6, RHOA_PONAB
P61589, RHOA_RATQ92963, RIT1_HUMANP70426, RIT1_MOUSE
Q99578, RIT2_HUMANP70425, RIT2_MOUSEQ5BJQ5, RIT2_RAT
A6NIZ1, RP1BL_HUMANQ92737, RSLAA_HUMANQ8K5A4, RSLAA_MOUSE
Q96S79, RSLAB_HUMANQ5SSG5, RSLAB_MOUSEQ6T310, RSLBA_HUMAN
Q6IMB1, RSLBA_MOUSEQ6IMA3, RSLBA_RATQ5E9J3, RSLBB_BOVIN
Q6P0U3, RSLBB_DANREQ9BPW5, RSLBB_HUMANQ922H7, RSLBB_MOUSE
Q6IMA7, RSLBB_RATQ8AVS6, RSLBB_XENLAQ5FVY2, RSLBB_XENTR
A1DZY4, RSLBL_DANREP52498, RSR1_CANAXP13856, RSR1_YEAST
O04834, SAR1A_ARATHQ3T0D7, SAR1A_BOVINO04266, SAR1A_BRACM
Q559R0, SAR1A_DICDIQ9NR31, SAR1A_HUMANP36536, SAR1A_MOUSE
Q52NJ3, SAR1A_PIGQ5R548, SAR1A_PONABQ01474, SAR1B_ARATH
Q3T0T7, SAR1B_BOVINO04267, SAR1B_BRACMQ9QVY3, SAR1B_CRIGR
Q54Y14, SAR1B_DICDIQ9Y6B6, SAR1B_HUMANQ9CQC9, SAR1B_MOUSE
Q5PYH3, SAR1B_PIGQ5HZY2, SAR1B_RATQ23445, SAR1_CAEEL
Q8MQT8, SAR1_GIAINP52885, SAR1_TOBACP44280, Y1637_HAEIN
P76046, YCJX_ECOLIQ8EG04, YCJX_SHEON

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-