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ENZYME

ENZYME entry: EC 3.8.1.10

PURL: https://purl.expasy.org/enzyme/EC/3.8.1.10
Accepted Name
2-haloacid dehalogenase (configuration-inverting)
Alternative Name(s)
2-haloalkanoic acid dehalogenase
2-haloalkanoid acid halidohydrolase
DL-2-haloacid dehalogenase
DL-2-haloacid dehalogenase (inversion of configuration)
DL-2-haloacid halidohydrolase (inversion of configuration)
DL-DEXi
Reaction catalysed
  • an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
  • an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
Comment(s)
  • Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2.
  • The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less (see also EC 3.8.1.2, EC 3.8.1.9 and EC 3.8.1.11).
Cross-references
BRENDA3.8.1.10
EC2PDB3.8.1.10
ExplorEnz3.8.1.10
KEGG Ligand Database for Enzyme Nomenclature3.8.1.10
IUBMB Enzyme Nomenclature3.8.1.10
MEDLINEFind literature relating to 3.8.1.10
MetaCyc3.8.1.10
Rhea expert-curated reactions3.8.1.10
UniProtKB/Swiss-Prot
O06652, HADDL_PSES4Q59168, HDDL_ALCXX

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