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ENZYME entry: EC 3.8.1.10
Accepted Name |
2-haloacid dehalogenase (configuration-inverting).
|
Alternative Name(s) |
2-haloalkanoic acid dehalogenase. |
2-haloalkanoid acid halidohydrolase. |
DL-2-haloacid dehalogenase. |
DL-2-haloacid dehalogenase (inversion of configuration). |
DL-2-haloacid halidohydrolase (inversion of configuration). |
DL-DEXi. |
Reaction catalysed |
- an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
- an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
|
Comment(s) |
- Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the
corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with
inversion of configuration at C-2.
- The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids
whose carbon chain lengths are five or less (see also EC 3.8.1.2,
EC 3.8.1.9 and EC 3.8.1.11).
|
Cross-references |
BRENDA | 3.8.1.10 |
EC2PDB | 3.8.1.10 |
ExplorEnz | 3.8.1.10 |
PRIAM enzyme-specific profiles | 3.8.1.10 |
KEGG Ligand Database for Enzyme Nomenclature | 3.8.1.10 |
IUBMB Enzyme Nomenclature | 3.8.1.10 |
IntEnz | 3.8.1.10 |
MEDLINE | Find literature relating to 3.8.1.10 |
MetaCyc | 3.8.1.10 |
Rhea expert-curated reactions | 3.8.1.10 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.8.1.-
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