ENZYME entry: EC 4.2.2.1
Accepted Name |
hyaluronate lyase.
|
Alternative Name(s) |
hyaluronidase. |
mucinase. |
spreading factor. |
Reaction catalysed |
[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O |
Comment(s) |
- The enzyme catalyzes the degradation of hyaluronan by a beta-
elimination reaction.
- Also acts on chondroitin.
- The product is more systematically known as 3-(4-deoxy-alpha-L-threo-
hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose.
- Formerly EC 4.2.99.1.
|
Cross-references |
BRENDA | 4.2.2.1 |
EC2PDB | 4.2.2.1 |
ExplorEnz | 4.2.2.1 |
PRIAM enzyme-specific profiles | 4.2.2.1 |
KEGG Ligand Database for Enzyme Nomenclature | 4.2.2.1 |
IUBMB Enzyme Nomenclature | 4.2.2.1 |
IntEnz | 4.2.2.1 |
MEDLINE | Find literature relating to 4.2.2.1 |
MetaCyc | 4.2.2.1 |
Rhea expert-curated reactions | 4.2.2.1 |
UniProtKB/Swiss-Prot |
|
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