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ENZYME entry: EC 4.2.2.1

Accepted Name
hyaluronate lyase.
Alternative Name(s)
hyaluronidase.
mucinase.
spreading factor.
Reaction catalysed
[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O
Comment(s)
  • The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction.
  • Also acts on chondroitin.
  • The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose.
  • Formerly EC 4.2.99.1.
Cross-references
BRENDA4.2.2.1
EC2PDB4.2.2.1
ExplorEnz4.2.2.1
PRIAM enzyme-specific profiles4.2.2.1
KEGG Ligand Database for Enzyme Nomenclature4.2.2.1
IUBMB Enzyme Nomenclature4.2.2.1
IntEnz4.2.2.1
MEDLINEFind literature relating to 4.2.2.1
MetaCyc4.2.2.1
Rhea expert-curated reactions4.2.2.1
UniProtKB/Swiss-Prot
P0CZ00, HYSA_CUTAC;  P0CZ01, HYSA_CUTAK;  Q59801, HYSA_STAA8;  
Q53591, HYSA_STRA3;  Q54873, HYSA_STRPN;  A0A3D9VCI6, HYSA_THECX;  
B2FHL8, PL_STRMK;  

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