Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm
CEST. Apologies for the inconvenience.
A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.2.2.1
| Accepted Name |
|---|
| Hyaluronate lyase.
|
| Alternative Name(s) |
|---|
| Hyaluronidase. |
| Mucinase. |
| Spreading factor. |
| Reaction catalysed |
|---|
| Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine |
| Comment(s) |
|---|
- The enzyme catalyzes the degradation of hyaluronan by a beta-
elimination reaction.
- Also acts on chondroitin.
- The product is more systematically known as 3-(4-deoxy-alpha-L-threo-
hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose.
- Formerly EC 4.2.99.1.
|
| Cross-references |
|---|
| BRENDA | 4.2.2.1 |
| EC2PDB | 4.2.2.1 |
| ExplorEnz | 4.2.2.1 |
| PRIAM enzyme-specific profiles | 4.2.2.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.2.1 |
| IUBMB Enzyme Nomenclature | 4.2.2.1 |
| IntEnz | 4.2.2.1 |
| MEDLINE | Find literature relating to 4.2.2.1 |
| MetaCyc | 4.2.2.1 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-