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ENZYME

ENZYME entry: EC 4.2.2.1

PURL: https://purl.expasy.org/enzyme/EC/4.2.2.1
Accepted Name
hyaluronate lyase
Alternative Name(s)
hyaluronidase
mucinase
spreading factor
Reaction catalysed
[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O
Comment(s)
  • The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction.
  • Also acts on chondroitin.
  • The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose.
  • Formerly EC 4.2.99.1.
Cross-references
BRENDA4.2.2.1
EC2PDB4.2.2.1
ExplorEnz4.2.2.1
KEGG Ligand Database for Enzyme Nomenclature4.2.2.1
IUBMB Enzyme Nomenclature4.2.2.1
MEDLINEFind literature relating to 4.2.2.1
MetaCyc4.2.2.1
Rhea expert-curated reactions4.2.2.1
UniProtKB/Swiss-Prot
A0A2B7ICX0, HYLA_CUTACP0CZ00, HYLB_CUTACP0CZ01, HYLB_CUTAK
Q837L8, HYLB_ENTFAQ59801, HYSA_STAA8Q53591, HYSA_STRA3
Q54873, HYSA_STRPNA0A3D9VCI6, HYSA_THECXB2FHL8, PL_STRMK

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-