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ENZYME

ENZYME entry: EC 4.2.2.29

PURL: https://purl.expasy.org/enzyme/EC/4.2.2.29
Accepted Name
peptidoglycan lytic transglycosylase
Alternative Name(s)
endolytic murein transglycosylase
endolytic transglycosylase
lytic murein transglycosylase
lytic transglycosylase
Reaction catalysed
a peptidoglycan chain = a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end
Comment(s)
  • A group of bacterial enzymes that catalyze the non-hydrolytic cleavage of peptidoglycan (PG).
  • The enzymes fragment the polysaccharide chain at the beta-1,4- glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues by an intramolecular cyclization of the N-acetylmuramyl moiety to yield a 1,6-anhydro-N-acetyl-beta-D-muramyl product.
  • Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand.
  • The MtlG enzyme of Gram-negative bacteria may function to regulate glycan strand length within the PG polymer.
Cross-references
BRENDA4.2.2.29
EC2PDB4.2.2.29
ExplorEnz4.2.2.29
KEGG Ligand Database for Enzyme Nomenclature4.2.2.29
IUBMB Enzyme Nomenclature4.2.2.29
MEDLINEFind literature relating to 4.2.2.29
MetaCyc4.2.2.29
Rhea expert-curated reactions4.2.2.29
UniProtKB/Swiss-Prot
O34758, MLTG_BACSUP28306, MLTG_ECOLIP44720, MLTG_HAEIN
A0A0H2ZLQ1, MLTG_STRP2Q8CYJ8, MLTG_STRR6

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