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ENZYME entry: EC 4.2.3.121

Accepted Name
(+)-alpha-pinene synthase.
Alternative Name(s)
(+)-alpha-pinene cyclase.
Reaction catalysed
(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate
Comment(s)
  • Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene.
  • (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate.
  • The 4-pro-R hydrogen of geranyl diphosphate is lost.
  • With synthase II of Pinus taeda (loblolly pine) (+)-beta-pinene was the only product.
  • See also EC 4.2.3.122 and EC 4.2.3.116.
Cross-references
BRENDA4.2.3.121
EC2PDB4.2.3.121
ExplorEnz4.2.3.121
PRIAM enzyme-specific profiles4.2.3.121
KEGG Ligand Database for Enzyme Nomenclature4.2.3.121
IUBMB Enzyme Nomenclature4.2.3.121
IntEnz4.2.3.121
MEDLINEFind literature relating to 4.2.3.121
MetaCyc4.2.3.121
Rhea expert-curated reactions4.2.3.121
UniProtKB/Swiss-Prot
O81192, BPPS_SALOF;  R9QMY8, CAMPS_PINCO;  Q84KL3, PT30_PINTA;  
R9QMR1, RAPN1_PINBN;  R9QMW2, RAPN1_PINCO;  A7IZZ2, TPS2_CANSA;  

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