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ENZYME entry: EC 4.2.3.152

Accepted Name
2-epi-5-epi-valiolone synthase.
Alternative Name(s)
C(7)-cyclitol synthase.
Reaction catalysed
D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate
Comment(s)
  • The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate.
  • It requires a divalent metal ion (Zn(2+) or Co(2+)) and an NAD(+) cofactor, which is transiently reduced during the reaction.
  • The enzyme is involved in the biosynthesis of C(7)N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A.
  • Cf. EC 4.2.3.154 and EC 4.2.3.155.
Cross-references
BRENDA4.2.3.152
EC2PDB4.2.3.152
ExplorEnz4.2.3.152
PRIAM enzyme-specific profiles4.2.3.152
KEGG Ligand Database for Enzyme Nomenclature4.2.3.152
IUBMB Enzyme Nomenclature4.2.3.152
IntEnz4.2.3.152
MEDLINEFind literature relating to 4.2.3.152
MetaCyc4.2.3.152
UniProtKB/Swiss-Prot
Q9ZAE9, ACBC_ACTS5;  A1YPR2, CETA_ACTSX;  E3FKM2, EEVS_STIAD;  
B0B0T7, EEVS_STRGA;  A8D7K2, SALQ_STRA4;  H2K887, VALA_STRHJ;  

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