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ENZYME entry: EC 4.2.3.153

Accepted Name
(5-formylfuran-3-yl)methyl phosphate synthase.
Alternative Name(s)
2-furaldehyde phosphate synthase.
4-HFC-P synthase.
Reaction catalysed
2 D-glyceraldehyde 3-phosphate <=> (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H(2)O
Comment(s)
  • The enzyme catalyzes the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran.
  • The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization.
  • Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.
  • Formerly EC 4.1.99.21.
Cross-references
BRENDA4.2.3.153
EC2PDB4.2.3.153
ExplorEnz4.2.3.153
PRIAM enzyme-specific profiles4.2.3.153
KEGG Ligand Database for Enzyme Nomenclature4.2.3.153
IUBMB Enzyme Nomenclature4.2.3.153
IntEnz4.2.3.153
MEDLINEFind literature relating to 4.2.3.153
MetaCyc4.2.3.153
UniProtKB/Swiss-Prot
O28087, MFNB_ARCFU;  A6UU96, MFNB_META3;  Q8THS6, MFNB_METAC;  
Q46DH3, MFNB_METBF;  Q58499, MFNB_METJA;  Q8TUZ9, MFNB_METKA;  
A4FY92, MFNB_METM5;  A9A7Q1, MFNB_METM6;  A6VK15, MFNB_METM7;  
Q8PXV2, MFNB_METMA;  Q6LZC1, MFNB_METMP;  A5UNQ5, MFNB_METS3;  
O26244, MFNB_METTH;  A6USK6, MFNB_METVS;  Q9X4H5, Y264_KITAU;  
Q8GEK8, Y264_METEX;  B1W5S5, Y6403_STRGG;  Q9ZBH3, Y6440_STRCO;  

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