Expasy logo

ENZYME

ENZYME entry: EC 4.2.3.153

PURL: https://purl.expasy.org/enzyme/EC/4.2.3.153
Accepted Name
(5-formylfuran-3-yl)methyl phosphate synthase
Alternative Name(s)
2-furaldehyde phosphate synthase
4-HFC-P synthase
Reaction catalysed
2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + phosphate + 2 H2O
Comment(s)
  • The enzyme catalyzes the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran.
  • The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization.
  • Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.
  • Formerly EC 4.1.99.21.
Cross-references
BRENDA4.2.3.153
EC2PDB4.2.3.153
ExplorEnz4.2.3.153
KEGG Ligand Database for Enzyme Nomenclature4.2.3.153
IUBMB Enzyme Nomenclature4.2.3.153
MEDLINEFind literature relating to 4.2.3.153
MetaCyc4.2.3.153
Rhea expert-curated reactions4.2.3.153
UniProtKB/Swiss-Prot
O28087, MFNB_ARCFUA6UU96, MFNB_META3Q8THS6, MFNB_METAC
Q46DH3, MFNB_METBFQ58499, MFNB_METJAQ8TUZ9, MFNB_METKA
A4FY92, MFNB_METM5A9A7Q1, MFNB_METM6A6VK15, MFNB_METM7
Q8PXV2, MFNB_METMAQ6LZC1, MFNB_METMPA5UNQ5, MFNB_METS3
O26244, MFNB_METTHA6USK6, MFNB_METVSQ9X4H5, Y264_KITAU
Q8GEK8, Y264_METEXB1W5S5, Y6403_STRGGQ9ZBH3, Y6440_STRCO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-