Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the inconvenience.

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing).
Reaction catalysed
(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (see EC, while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene (see EC, as well as (+)-endo-beta-bergamotene.
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation.
PRIAM enzyme-specific profiles4.2.3.53
KEGG Ligand Database for Enzyme Nomenclature4.2.3.53
IUBMB Enzyme Nomenclature4.2.3.53
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-