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ENZYME entry: EC 4.2.3.96

Accepted Name
Avermitilol synthase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + H(2)O <=> avermitilol + diphosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol.
  • The (1S)-hydrogen of farnesyl diphosphate is retained.
Cross-references
BRENDA4.2.3.96
EC2PDB4.2.3.96
ExplorEnz4.2.3.96
PRIAM enzyme-specific profiles4.2.3.96
KEGG Ligand Database for Enzyme Nomenclature4.2.3.96
IUBMB Enzyme Nomenclature4.2.3.96
IntEnz4.2.3.96
MEDLINEFind literature relating to 4.2.3.96
MetaCyc4.2.3.96
UniProtKB/Swiss-Prot
Q82RR7, TPC1_STRAW

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