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ENZYME

ENZYME entry: EC 4.2.99.18

PURL: https://purl.expasy.org/enzyme/EC/4.2.99.18
Accepted Name
DNA-(apurinic or apyrimidinic site) lyase
Alternative Name(s)
AP endonuclease class I
AP lyase
deoxyribonuclease (apurinic or apyrimidinic)
E.coli endonuclease III
endodeoxyribonuclease (apurinic or apyrimidinic)
Micrococcus luteus UV endonuclease
phage-T4 UV endonuclease
Reaction catalysed
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)
Comment(s)
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
  • Formerly EC 3.1.25.2.
Cross-references
BRENDA4.2.99.18
EC2PDB4.2.99.18
ExplorEnz4.2.99.18
KEGG Ligand Database for Enzyme Nomenclature4.2.99.18
IUBMB Enzyme Nomenclature4.2.99.18
MEDLINEFind literature relating to 4.2.99.18
MetaCyc4.2.99.18
Rhea expert-curated reactions4.2.99.18
UniProtKB/Swiss-Prot
Q9YE60, AGOG_AERPEQ8TXW8, AGOG_METKAQ6M0G7, AGOG_METMP
Q74MX2, AGOG_NANEQQ9UZY0, AGOG_PYRABQ8ZVK6, AGOG_PYRAE
Q8U2D5, AGOG_PYRFUO58954, AGOG_PYRHOQ5JI79, AGOG_THEKO
Q13686, ALKB1_HUMANP0CB42, ALKB1_MOUSEQ27958, DPOLB_BOVIN
Q6DRD3, DPOLB_DANREP06746, DPOLB_HUMANQ8K409, DPOLB_MOUSE
P06766, DPOLB_RATO57383, DPOLB_XENLAP39788, END3_BACSU
P57219, END3_BUCAIQ8KA16, END3_BUCAPQ89AW4, END3_BUCBP
P0AB84, END3_ECOL6P0AB83, END3_ECOLIP44319, END3_HAEIN
Q58030, END3_METJAP63541, END3_MYCBOQ9CB92, END3_MYCLE
P9WQ10, END3_MYCTOP9WQ11, END3_MYCTUQ92GH4, END3_RICCN
Q4UK93, END3_RICFEO05956, END3_RICPRQ68W04, END3_RICTY
Q4J8R2, END3_SULACP73715, END3_SYNY3Q9WYK0, END3_THEMA
O83754, END3_TREPAP04418, END5_BPT4P64159, END8A_MYCBO
P9WNB8, END8A_MYCTOP9WNB9, END8A_MYCTUP64157, END8B_MYCBO
A0QT90, END8B_MYCS2P9WNC0, END8B_MYCTOP9WNC1, END8B_MYCTU
O86820, END8B_STRCOA8AJA5, END8_CITK8A7MQW6, END8_CROS8
A7ZJ95, END8_ECO24B7ULJ5, END8_ECO27B7MFX3, END8_ECO45
B7LAC0, END8_ECO55Q8X9C6, END8_ECO57B7NMR0, END8_ECO7I
B7MPL0, END8_ECO81B7M5M8, END8_ECO8AC4ZWI9, END8_ECOBW
B1X6P5, END8_ECODHA7ZXX5, END8_ECOHSA1A8X0, END8_ECOK1
Q0TJX8, END8_ECOL5Q8FJU5, END8_ECOL6B1IY15, END8_ECOLC
P50465, END8_ECOLIB7N9V3, END8_ECOLUB6I7Y5, END8_ECOSE
B1LLF1, END8_ECOSMQ1REK9, END8_ECOUTA4W871, END8_ENT38
A6T6E8, END8_KLEP7B5XZD9, END8_KLEV3Q6D7H0, END8_PECAS
C6DCC8, END8_PECCPB5EZF2, END8_SALA4A9MJM8, END8_SALAR
Q57RM1, END8_SALCHB5FNF0, END8_SALDCB5QWF8, END8_SALEP
B5R679, END8_SALG2B4TBC8, END8_SALHSB4SZD3, END8_SALNS
Q5PCL7, END8_SALPAA9MTR2, END8_SALPBC0PWD7, END8_SALPC
B5BC82, END8_SALPKB4TQ44, END8_SALSVQ8Z8D2, END8_SALTI
E1W9M1, END8_SALTSP0CL05, END8_SALTYB2TU97, END8_SHIB3
Q324J6, END8_SHIBSQ32IL9, END8_SHIDSQ0T6V4, END8_SHIF8
Q83LZ7, END8_SHIFLQ3Z489, END8_SHISSP9WNC2, FPG1_MYCTO
P9WNC3, FPG1_MYCTUB0C5D4, FPG_ACAM1Q6FE90, FPG_ACIAD
B0VRV3, FPG_ACIBSA0LV85, FPG_ACIC1A5FZ95, FPG_ACICJ
B9ME52, FPG_ACIETB7J8I7, FPG_ACIF2B5ENT6, FPG_ACIF5
A1W4G6, FPG_ACISJA3N3S8, FPG_ACTP2B3GZD6, FPG_ACTP7
B0BU16, FPG_ACTPJA6VKA1, FPG_ACTSZA0KEN2, FPG_AERHH
A4STD1, FPG_AERS4B6JCQ7, FPG_AFIC5Q8UIH4, FPG_AGRFC
Q21XW7, FPG_ALBFTQ0VLB7, FPG_ALCBSQ5E8M1, FPG_ALIF1
B5FFG1, FPG_ALIFMQ0A598, FPG_ALKEHB9JZF5, FPG_ALLAM
B4S2C6, FPG_ALTMDO80358, FPG_ARATHQ5P728, FPG_AROAE
A8IQM5, FPG_AZOC5Q81L04, FPG_BACANQ72ZF1, FPG_BACC1
Q817G5, FPG_BACCRQ633L1, FPG_BACCZQ6HCU5, FPG_BACHK
Q65G93, FPG_BACLDO34403, FPG_BACSUA1UU20, FPG_BARBK
Q6G4T2, FPG_BARHEQ6G0L3, FPG_BARQUA9IN26, FPG_BART1
Q1LTS6, FPG_BAUCHQ6ML45, FPG_BDEBAB2IE81, FPG_BEII9
Q2KYB7, FPG_BORA1Q7W185, FPG_BORPAA9I6Y3, FPG_BORPD
Q7VUG7, FPG_BORPEQ89WC9, FPG_BRADUA5E887, FPG_BRASB
A4YJG9, FPG_BRASOC0Z7Z0, FPG_BREBNB2S9T2, FPG_BRUA1
Q2YQP8, FPG_BRUA2Q57A83, FPG_BRUABA9MAB2, FPG_BRUC2
C0RG65, FPG_BRUMBQ8YED2, FPG_BRUMEA5VTD0, FPG_BRUO2
Q8FXR6, FPG_BRUSUB1YN48, FPG_BURA4A0KAM1, FPG_BURCH
B4EAR7, FPG_BURCJQ39CU4, FPG_BURL3A9AEZ2, FPG_BURM1
A2S6C0, FPG_BURM9Q62FC7, FPG_BURMAA1UZN2, FPG_BURMS
Q1BTH0, FPG_BURO1A3NRA1, FPG_BURP0Q3JW82, FPG_BURP1
A3N5K5, FPG_BURP6Q63XL4, FPG_BURPSQ2T1B3, FPG_BURTA
A4JHZ1, FPG_BURVGQ3ABL4, FPG_CARHZB0T7D1, FPG_CAUSK
Q9A259, FPG_CAUVCB8GVY4, FPG_CAUVNB3PG51, FPG_CELJU
A3PFL2, FPG_CERS1Q3IY64, FPG_CERS4A4WVR6, FPG_CERS5
B9KQJ9, FPG_CERSKQ11AV8, FPG_CHESBA9WDC2, FPG_CHLAA
B8G9X1, FPG_CHLADQ7NQS5, FPG_CHRVOA8ARM2, FPG_CITK8
Q48AD4, FPG_COLP3C3PH91, FPG_CORA7Q6NGH4, FPG_CORDI
Q8FP17, FPG_COREFA4QFD9, FPG_CORGBQ8NNV7, FPG_CORGL
Q4JUY8, FPG_CORJKB1VG60, FPG_CORU7B1WTF7, FPG_CROS5
A7MQ97, FPG_CROS8Q1LRP7, FPG_CUPMCQ0KEP4, FPG_CUPNH
Q476F5, FPG_CUPPJB2AGU2, FPG_CUPTRP19210, FPG_CYTFI
Q479M6, FPG_DECARQ9RX22, FPG_DEIRAB8FU83, FPG_DESHD
Q24XW2, FPG_DESHYQ6APT2, FPG_DESPSA4J4X3, FPG_DESRM
A5EXK6, FPG_DICNVA8LNK8, FPG_DINSHA7ZTI6, FPG_ECO24
B7ULJ0, FPG_ECO27B7MFJ6, FPG_ECO45B7L758, FPG_ECO55
P64148, FPG_ECO57B5YWD3, FPG_ECO5EB7NPE1, FPG_ECO7I
B7N2X1, FPG_ECO81B7M4B9, FPG_ECO8AC4ZXM7, FPG_ECOBW
B1X969, FPG_ECODHA8A697, FPG_ECOHSA1AHG8, FPG_ECOK1
Q0TBH4, FPG_ECOL5Q8FC87, FPG_ECOL6B1IZF8, FPG_ECOLC
P05523, FPG_ECOLIB7NET9, FPG_ECOLUB6I3L2, FPG_ECOSE
B1LK72, FPG_ECOSMQ1R4V8, FPG_ECOUTA4Y028, FPG_ECTM1
C5B9D8, FPG_EDWI9A4W514, FPG_ENT38Q837G3, FPG_ENTFA
B2VF70, FPG_ERWT9Q2N7Y8, FPG_ERYLHB7LVJ6, FPG_ESCF3
B1YKA0, FPG_EXIS2C4L470, FPG_EXISAQ5NGY3, FPG_FRATT
B9M5V2, FPG_GEODFQ5KWC3, FPG_GEOKAQ39WD1, FPG_GEOMG
Q74EG5, FPG_GEOSLA5G7Q9, FPG_GEOURB8F586, FPG_GLAP5
Q7NFW7, FPG_GLOVIA9HI30, FPG_GLUDAQ5FN17, FPG_GLUOX
Q7VN67, FPG_HAEDUQ4QLW2, FPG_HAEI8A5UDC3, FPG_HAEIE
A5UI87, FPG_HAEIGP44948, FPG_HAEINQ2SPF3, FPG_HAHCH
Q9K855, FPG_HALH5A1WZG2, FPG_HALHLB0TER7, FPG_HELMI
A9B0X2, FPG_HERA2A4G916, FPG_HERARQ0I0X6, FPG_HISS1
B0UUX0, FPG_HISS2Q31EB2, FPG_HYDCUQ5QZC1, FPG_IDILO
A6T2R7, FPG_JANMAQ28JI5, FPG_JANSCA6W7S6, FPG_KINRD
A6TFM6, FPG_KLEP7B5XTG8, FPG_KLEV3Q5FIV8, FPG_LACAC
Q1G9A3, FPG_LACDAQ049F3, FPG_LACDBQ041U1, FPG_LACGA
A8YWE6, FPG_LACH4Q74IB5, FPG_LACJOQ9CIK4, FPG_LACLA
P42371, FPG_LACLCQ88WV4, FPG_LACPLC1DBB4, FPG_LARHH
Q38VS5, FPG_LATSSQ5X7I9, FPG_LEGPAQ5ZY18, FPG_LEGPH
Q5WYY6, FPG_LEGPLQ6AFJ3, FPG_LEIXXB1Y3P5, FPG_LEPCP
Q1WUN7, FPG_LIGS1Q92BF1, FPG_LISINQ71ZA3, FPG_LISMF
Q8Y6W7, FPG_LISMOA0L837, FPG_MAGMMQ65R59, FPG_MANSM
A6VSY6, FPG_MARMSA1U749, FPG_MARN8C6BUX8, FPG_MARSD
B7KN75, FPG_METC4Q602J1, FPG_METCAA9W8R7, FPG_METEP
Q1H3I3, FPG_METFKB8IIZ9, FPG_METNOB1ZGU8, FPG_METPB
B1LWY6, FPG_METRJB0UR68, FPG_METS4B8EKR5, FPG_METSB
Q5UQ00, FPG_MIMIVQ2RHE9, FPG_MOOTAA0QJ66, FPG_MYCA1
B1MDL2, FPG_MYCA9P64151, FPG_MYCBOA1KMR9, FPG_MYCBP
C1AG40, FPG_MYCBTP55825, FPG_MYCGEA4TE57, FPG_MYCGI
B8ZRZ2, FPG_MYCLBO69470, FPG_MYCLEQ6KHS0, FPG_MYCM1
B2HJJ6, FPG_MYCMMQ73VL9, FPG_MYCPAP75402, FPG_MYCPN
Q98QQ1, FPG_MYCPUA0QV21, FPG_MYCS2A3PXU1, FPG_MYCSJ
A1UED7, FPG_MYCSKQ1BAM5, FPG_MYCSSA5U6T0, FPG_MYCTA
A0PQ49, FPG_MYCUAA1T737, FPG_MYCVPQ5F8Z9, FPG_NEIG1
P57014, FPG_NEIMAP55044, FPG_NEIMBQ0AD66, FPG_NITEC
Q82S12, FPG_NITEUQ2YBI1, FPG_NITMUQ3J7U5, FPG_NITOC
Q726D5, FPG_NITV2Q3SWN3, FPG_NITWNQ5YS09, FPG_NOCFA
A1SLU7, FPG_NOCSJB2J5G0, FPG_NOSP7Q8YP80, FPG_NOSS1
Q2GAT0, FPG_NOVADQ8EPE6, FPG_OCEIHA1BAN2, FPG_PARDP
A7HZC4, FPG_PARL1Q7U4V2, FPG_PARMWB2JCP3, FPG_PARP8
B2SXG9, FPG_PARPJA8L594, FPG_PARS2Q6MCT3, FPG_PARUW
Q145W8, FPG_PARXLP57910, FPG_PASMUQ6DAV4, FPG_PECAS
C6DIB8, FPG_PECCPQ03GC2, FPG_PEDPAA1AV29, FPG_PELPD
A5D0T6, FPG_PELTSB4RC43, FPG_PHEZHQ8VW76, FPG_PHODP
Q7MY36, FPG_PHOLLQ6LVN0, FPG_PHOPRA1VKP2, FPG_POLNA
B1XS61, FPG_POLNSQ12DZ5, FPG_POLSJA3PB53, FPG_PROM0
A2C0H4, FPG_PROM1A8G2Y9, FPG_PROM2A9BDY5, FPG_PROM4
A2BUV8, FPG_PROM5Q31CK0, FPG_PROM9Q7VDK6, FPG_PROMA
B4F0X6, FPG_PROMHQ7V8Y5, FPG_PROMMQ7V2X4, FPG_PROMP
A2BPD1, FPG_PROMSQ46H41, FPG_PROMTQ48CK1, FPG_PSE14
Q15ZV5, FPG_PSEA6B7V2S0, FPG_PSEA8Q02U58, FPG_PSEAB
Q9L7T2, FPG_PSEAEQ1IGF3, FPG_PSEE4Q4K4A5, FPG_PSEF5
C3K3N6, FPG_PSEFSA5WAF9, FPG_PSEP1A6UYG0, FPG_PSEP7
Q3K566, FPG_PSEPFB0KN79, FPG_PSEPGQ88CQ5, FPG_PSEPK
B1J2M4, FPG_PSEPWQ88AH6, FPG_PSESMQ4ZM34, FPG_PSEU2
Q4FUU7, FPG_PSYA2A1SR12, FPG_PSYINQ8Y2D7, FPG_RALN1
B2UES0, FPG_RALPJB3PZ93, FPG_RHIE6Q2KDA9, FPG_RHIEC
Q1MMD9, FPG_RHIJ3Q98BG6, FPG_RHILOB5ZYK9, FPG_RHILW
Q59752, FPG_RHIMEA5VG06, FPG_RHIWRB6IVU4, FPG_RHOCS
C0ZXQ5, FPG_RHOE4Q0S2E0, FPG_RHOJRC1B2Q5, FPG_RHOOB
Q2J2I0, FPG_RHOP2Q07UF4, FPG_RHOP5Q6NDM1, FPG_RHOPA
Q21CD4, FPG_RHOPBQ13EN7, FPG_RHOPSB3Q620, FPG_RHOPT
Q2RMQ2, FPG_RHORTC3PLF5, FPG_RICAEA8GXR0, FPG_RICB8
Q1RJY6, FPG_RICBRA8EZP5, FPG_RICCKQ92GT4, FPG_RICCN
Q4UMW5, FPG_RICFEA8F2H0, FPG_RICM5C4K2K4, FPG_RICPU
B0BUU0, FPG_RICROA8GTA0, FPG_RICRSB7K1T1, FPG_RIPO1
A7NQM8, FPG_ROSCSQ16DL0, FPG_ROSDOA5UUN1, FPG_ROSS1
Q5LWT9, FPG_RUEPOQ1GC55, FPG_RUESTA1AW02, FPG_RUTMC
Q21EE3, FPG_SACD2A4FMJ7, FPG_SACENB5EXE0, FPG_SALA4
A8M661, FPG_SALAIA9MKN9, FPG_SALARQ57IA7, FPG_SALCH
B5FM59, FPG_SALDCB5R5F9, FPG_SALEPB5RGF2, FPG_SALG2
B4T9C0, FPG_SALHSB4SXD7, FPG_SALNSQ5PC09, FPG_SALPA
A9MVN0, FPG_SALPBC0Q1W8, FPG_SALPCB5BI09, FPG_SALPK
B4TZX7, FPG_SALSVQ8Z2H2, FPG_SALTIA4X4F8, FPG_SALTO
O54326, FPG_SALTYQ9X981, FPG_SERMAA8GLE2, FPG_SERP5
A1S1S3, FPG_SHEAMB8EDQ9, FPG_SHEB2A3CYP7, FPG_SHEB5
A6WUE9, FPG_SHEB8A9KW47, FPG_SHEB9Q12SR9, FPG_SHEDO
B0TN04, FPG_SHEHHA3QJA8, FPG_SHELPQ8E8D9, FPG_SHEON
A8HA27, FPG_SHEPAB8CVD1, FPG_SHEPWA0L2N2, FPG_SHESA
Q0HDC3, FPG_SHESMQ0HPK4, FPG_SHESRA1RE25, FPG_SHESW
B1KL38, FPG_SHEWMB2TTU9, FPG_SHIB3Q31UZ1, FPG_SHIBS
Q329M2, FPG_SHIDSQ0SYG3, FPG_SHIF8P64149, FPG_SHIFL
Q3YVZ7, FPG_SHISSQ5WEG7, FPG_SHOC1C3MCY7, FPG_SINFN
A6UFF8, FPG_SINMWQ2NQU4, FPG_SODGMQ01RU9, FPG_SOLUE
Q1GN82, FPG_SPHALQ3K028, FPG_STRA1P64152, FPG_STRA3
P64153, FPG_STRA5Q82JU0, FPG_STRAWQ9ZBQ6, FPG_STRCO
B1VYY1, FPG_STRGGB4SRN0, FPG_STRM5B2FU49, FPG_STRMK
P55045, FPG_STRMUQ9A131, FPG_STRP1P0DB14, FPG_STRP3
Q5XDE4, FPG_STRP6Q8P250, FPG_STRP8Q48UU6, FPG_STRPM
Q97R61, FPG_STRPNP0DB15, FPG_STRPQQ8DQ33, FPG_STRR6
Q5M0P0, FPG_STRT1Q5M576, FPG_STRT2A4VRM9, FPG_STUS1
Q67R59, FPG_SYMTHQ3A3F2, FPG_SYNC1P95744, FPG_SYNEL
Q08079, FPG_SYNP6Q0AVE3, FPG_SYNWWP74290, FPG_SYNY3
C5BLG1, FPG_TERTTQ47S77, FPG_THEFYB9L1Z5, FPG_THERP
Q72HN2, FPG_THET2O50606, FPG_THET8P59065, FPG_THEVB
Q3SLR9, FPG_THIDAB8GUQ6, FPG_THISHQ117D2, FPG_TRIEI
Q3MDP1, FPG_TRIV2Q9PQ76, FPG_UREPAC5CYZ1, FPG_VARPS
A5CX90, FPG_VESOHB7VHK6, FPG_VIBA3A7MSN3, FPG_VIBC1
A5F407, FPG_VIBC3Q9KVC5, FPG_VIBCHC3LQI3, FPG_VIBCM
Q87T81, FPG_VIBPAQ8DDY4, FPG_VIBVUQ7MPS3, FPG_VIBVY
Q73G10, FPG_WOLPMB3CM71, FPG_WOLPPQ5GS47, FPG_WOLTR
C0R4I6, FPG_WOLWRQ8PEQ4, FPG_XANACQ4UNU6, FPG_XANC8
B0RZ50, FPG_XANCBQ8P3C4, FPG_XANCPQ3BM92, FPG_XANE5
Q2P8V2, FPG_XANOMB2STU3, FPG_XANOPQ5H667, FPG_XANOR
A7IKJ3, FPG_XANP2P64154, FPG_XYLFAP64155, FPG_XYLFT
A1JHR7, FPG_YERE8A7FCT7, FPG_YERP3Q1C270, FPG_YERPA
B2JYN6, FPG_YERPBQ8ZJP0, FPG_YERPEA9R677, FPG_YERPG
Q1CD05, FPG_YERPNA4TSD4, FPG_YERPPQ66GD3, FPG_YERPS
B1JQX0, FPG_YERPYQ9X3X1, FPG_ZYMMOQ96FI4, NEIL1_HUMAN
Q8K4Q6, NEIL1_MOUSEQ6IE77, NEIL2_BOVINQ969S2, NEIL2_HUMAN
Q6R2P8, NEIL2_MOUSEQ5RAJ7, NEIL2_PONABQ3MHN7, NEIL3_BOVIN
Q8TAT5, NEIL3_HUMANQ8K203, NEIL3_MOUSEA0A1L8HU22, NEIL3_XENLA
Q9SIC4, NTH1_ARATHP31378, NTH1_YEASTB9DFZ0, NTH2_ARATH
Q08214, NTH2_YEASTQ2KID2, NTH_BOVINP54137, NTH_CAEEL
A7M7B9, NTH_CHICKC8VC05, NTH_EMENIQ8SRB8, NTH_ENCCU
P78549, NTH_HUMANO35980, NTH_MOUSEQ09907, NTH_SCHPO
O66612, OGG1_AQUAEQ9FNY7, OGG1_ARATHO29876, OGG1_ARCFU
Q9V3I8, OGG1_DROMEQ8R689, OGG1_FUSNNO15527, OGG1_HUMAN
B1L640, OGG1_KORCOQ58134, OGG1_METJAA4YHC9, OGG1_METS5
O27397, OGG1_METTHO08760, OGG1_MOUSEQ6L1T6, OGG1_PICTO
O70249, OGG1_RATC3NHM4, OGG1_SACI1C3MPU9, OGG1_SACI2
C3N5H5, OGG1_SACI3C3MUW1, OGG1_SACI4C4KH41, OGG1_SACI6
C3NE39, OGG1_SACI7Q97ZK2, OGG1_SACS2Q4J929, OGG1_SULAC
Q972A8, OGG1_SULTOQ9HM55, OGG1_THEACQ9X2E1, OGG1_THEMA
B9K7J6, OGG1_THENNA5ILP7, OGG1_THEP1B1LAK2, OGG1_THESQ
Q97CP1, OGG1_THEVOP53397, OGG1_YEASTQ9SJQ6, ROS1_ARATH
P02350, RS3A_XENLAP47835, RS3B_XENLAP79891, RS3_AMBME
Q3T169, RS3_BOVINE2RH47, RS3_CANLFP23396, RS3_HUMAN
Q90YS2, RS3_ICTPUP62908, RS3_MOUSEQ0Z8U2, RS3_PIG
Q5R465, RS3_PONABG1TNM3, RS3_RABITP62909, RS3_RAT
O26314, UREND_METTHP13010, XRCC5_HUMANP27641, XRCC5_MOUSE
Q6DDS9, XRCC5_XENLAO93257, XRCC6_CHICKP12956, XRCC6_HUMAN
P23475, XRCC6_MOUSE

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