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ENZYME

ENZYME entry: EC 4.2.99.18

Accepted Name
DNA-(apurinic or apyrimidinic site) lyase
Alternative Name(s)
AP endonuclease class I
AP lyase
deoxyribonuclease (apurinic or apyrimidinic)
E.coli endonuclease III
endodeoxyribonuclease (apurinic or apyrimidinic)
Micrococcus luteus UV endonuclease
phage-T4 UV endonuclease
Reaction catalysed
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)
Comment(s)
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
  • Formerly EC 3.1.25.2.
Cross-references
BRENDA4.2.99.18
EC2PDB4.2.99.18
ExplorEnz4.2.99.18
PRIAM enzyme-specific profiles4.2.99.18
KEGG Ligand Database for Enzyme Nomenclature4.2.99.18
IUBMB Enzyme Nomenclature4.2.99.18
IntEnz4.2.99.18
MEDLINEFind literature relating to 4.2.99.18
MetaCyc4.2.99.18
Rhea expert-curated reactions4.2.99.18
UniProtKB/Swiss-Prot
Q9YE60, AGOG_AERPEQ8TXW8, AGOG_METKAQ6M0G7, AGOG_METMP
Q74MX2, AGOG_NANEQQ9UZY0, AGOG_PYRABQ8ZVK6, AGOG_PYRAE
Q8U2D5, AGOG_PYRFUO58954, AGOG_PYRHOQ5JI79, AGOG_THEKO
Q13686, ALKB1_HUMANP0CB42, ALKB1_MOUSEQ27958, DPOLB_BOVIN
Q6DRD3, DPOLB_DANREP06746, DPOLB_HUMANQ8K409, DPOLB_MOUSE
P06766, DPOLB_RATO57383, DPOLB_XENLAP39788, END3_BACSU
P57219, END3_BUCAIQ8KA16, END3_BUCAPQ89AW4, END3_BUCBP
P0AB84, END3_ECOL6P0AB83, END3_ECOLIP44319, END3_HAEIN
Q58030, END3_METJAP63541, END3_MYCBOQ9CB92, END3_MYCLE
P9WQ10, END3_MYCTOP9WQ11, END3_MYCTUQ92GH4, END3_RICCN
Q4UK93, END3_RICFEO05956, END3_RICPRQ68W04, END3_RICTY
P73715, END3_SYNY3Q9WYK0, END3_THEMAO83754, END3_TREPA
P04418, END5_BPT4P64159, END8A_MYCBOP9WNB8, END8A_MYCTO
P9WNB9, END8A_MYCTUP64157, END8B_MYCBOP9WNC0, END8B_MYCTO
P9WNC1, END8B_MYCTUO86820, END8B_STRCOA8AJA5, END8_CITK8
A7MQW6, END8_CROS8A7ZJ95, END8_ECO24B7ULJ5, END8_ECO27
B7MFX3, END8_ECO45B7LAC0, END8_ECO55Q8X9C6, END8_ECO57
B7NMR0, END8_ECO7IB7MPL0, END8_ECO81B7M5M8, END8_ECO8A
C4ZWI9, END8_ECOBWB1X6P5, END8_ECODHA7ZXX5, END8_ECOHS
A1A8X0, END8_ECOK1Q0TJX8, END8_ECOL5Q8FJU5, END8_ECOL6
B1IY15, END8_ECOLCP50465, END8_ECOLIB7N9V3, END8_ECOLU
B6I7Y5, END8_ECOSEB1LLF1, END8_ECOSMQ1REK9, END8_ECOUT
A4W871, END8_ENT38B5XZD9, END8_KLEP3A6T6E8, END8_KLEP7
Q6D7H0, END8_PECASC6DCC8, END8_PECCPB5EZF2, END8_SALA4
A9MJM8, END8_SALARQ57RM1, END8_SALCHB5FNF0, END8_SALDC
B5QWF8, END8_SALEPB5R679, END8_SALG2B4TBC8, END8_SALHS
B4SZD3, END8_SALNSQ5PCL7, END8_SALPAA9MTR2, END8_SALPB
C0PWD7, END8_SALPCB5BC82, END8_SALPKB4TQ44, END8_SALSV
Q8Z8D2, END8_SALTIE1W9M1, END8_SALTSP0CL05, END8_SALTY
B2TU97, END8_SHIB3Q324J6, END8_SHIBSQ32IL9, END8_SHIDS
Q0T6V4, END8_SHIF8Q83LZ7, END8_SHIFLQ3Z489, END8_SHISS
P9WNC2, FPG1_MYCTOP9WNC3, FPG1_MYCTUB0C5D4, FPG_ACAM1
Q6FE90, FPG_ACIADB0VRV3, FPG_ACIBSA0LV85, FPG_ACIC1
A5FZ95, FPG_ACICJB9ME52, FPG_ACIETB7J8I7, FPG_ACIF2
B5ENT6, FPG_ACIF5A1W4G6, FPG_ACISJA3N3S8, FPG_ACTP2
B3GZD6, FPG_ACTP7B0BU16, FPG_ACTPJA6VKA1, FPG_ACTSZ
A0KEN2, FPG_AERHHA4STD1, FPG_AERS4B6JCQ7, FPG_AFIC5
Q8UIH4, FPG_AGRFCQ21XW7, FPG_ALBFTQ0VLB7, FPG_ALCBS
Q5E8M1, FPG_ALIF1B5FFG1, FPG_ALIFMQ0A598, FPG_ALKEH
B9JZF5, FPG_ALLAMB4S2C6, FPG_ALTMDO80358, FPG_ARATH
Q5P728, FPG_AROAEA8IQM5, FPG_AZOC5Q81L04, FPG_BACAN
Q72ZF1, FPG_BACC1Q817G5, FPG_BACCRQ633L1, FPG_BACCZ
Q6HCU5, FPG_BACHKQ65G93, FPG_BACLDO34403, FPG_BACSU
A1UU20, FPG_BARBKQ6G4T2, FPG_BARHEQ6G0L3, FPG_BARQU
A9IN26, FPG_BART1Q1LTS6, FPG_BAUCHQ6ML45, FPG_BDEBA
B2IE81, FPG_BEII9Q2KYB7, FPG_BORA1Q7W185, FPG_BORPA
A9I6Y3, FPG_BORPDQ7VUG7, FPG_BORPEQ89WC9, FPG_BRADU
A5E887, FPG_BRASBA4YJG9, FPG_BRASOC0Z7Z0, FPG_BREBN
B2S9T2, FPG_BRUA1Q2YQP8, FPG_BRUA2Q57A83, FPG_BRUAB
A9MAB2, FPG_BRUC2C0RG65, FPG_BRUMBQ8YED2, FPG_BRUME
A5VTD0, FPG_BRUO2Q8FXR6, FPG_BRUSUB1YN48, FPG_BURA4
A0KAM1, FPG_BURCHB4EAR7, FPG_BURCJQ39CU4, FPG_BURL3
A9AEZ2, FPG_BURM1A2S6C0, FPG_BURM9Q62FC7, FPG_BURMA
A1UZN2, FPG_BURMSQ1BTH0, FPG_BURO1A3NRA1, FPG_BURP0
Q3JW82, FPG_BURP1A3N5K5, FPG_BURP6Q63XL4, FPG_BURPS
Q2T1B3, FPG_BURTAA4JHZ1, FPG_BURVGQ3ABL4, FPG_CARHZ
B0T7D1, FPG_CAUSKQ9A259, FPG_CAUVCB8GVY4, FPG_CAUVN
B3PG51, FPG_CELJUA3PFL2, FPG_CERS1Q3IY64, FPG_CERS4
A4WVR6, FPG_CERS5B9KQJ9, FPG_CERSKQ11AV8, FPG_CHESB
A9WDC2, FPG_CHLAAB8G9X1, FPG_CHLADQ7NQS5, FPG_CHRVO
A8ARM2, FPG_CITK8Q48AD4, FPG_COLP3C3PH91, FPG_CORA7
Q6NGH4, FPG_CORDIQ8FP17, FPG_COREFA4QFD9, FPG_CORGB
Q8NNV7, FPG_CORGLQ4JUY8, FPG_CORJKB1VG60, FPG_CORU7
B1WTF7, FPG_CROS5A7MQ97, FPG_CROS8Q1LRP7, FPG_CUPMC
Q0KEP4, FPG_CUPNHQ476F5, FPG_CUPPJB2AGU2, FPG_CUPTR
P19210, FPG_CYTFIQ479M6, FPG_DECARQ9RX22, FPG_DEIRA
B8FU83, FPG_DESHDQ24XW2, FPG_DESHYQ6APT2, FPG_DESPS
A4J4X3, FPG_DESRMA5EXK6, FPG_DICNVA8LNK8, FPG_DINSH
A7ZTI6, FPG_ECO24B7ULJ0, FPG_ECO27B7MFJ6, FPG_ECO45
B7L758, FPG_ECO55P64148, FPG_ECO57B5YWD3, FPG_ECO5E
B7NPE1, FPG_ECO7IB7N2X1, FPG_ECO81B7M4B9, FPG_ECO8A
C4ZXM7, FPG_ECOBWB1X969, FPG_ECODHA8A697, FPG_ECOHS
A1AHG8, FPG_ECOK1Q0TBH4, FPG_ECOL5Q8FC87, FPG_ECOL6
B1IZF8, FPG_ECOLCP05523, FPG_ECOLIB7NET9, FPG_ECOLU
B6I3L2, FPG_ECOSEB1LK72, FPG_ECOSMQ1R4V8, FPG_ECOUT
C5B9D8, FPG_EDWI9A4W514, FPG_ENT38Q837G3, FPG_ENTFA
B2VF70, FPG_ERWT9Q2N7Y8, FPG_ERYLHB7LVJ6, FPG_ESCF3
B1YKA0, FPG_EXIS2C4L470, FPG_EXISAA8L594, FPG_FRASN
Q5NGY3, FPG_FRATTB9M5V2, FPG_GEODFQ5KWC3, FPG_GEOKA
Q39WD1, FPG_GEOMGQ74EG5, FPG_GEOSLA5G7Q9, FPG_GEOUR
B8F586, FPG_GLAP5Q7NFW7, FPG_GLOVIA9HI30, FPG_GLUDA
Q5FN17, FPG_GLUOXQ7VN67, FPG_HAEDUQ4QLW2, FPG_HAEI8
A5UDC3, FPG_HAEIEA5UI87, FPG_HAEIGP44948, FPG_HAEIN
Q2SPF3, FPG_HAHCHQ9K855, FPG_HALH5A1WZG2, FPG_HALHL
B0TER7, FPG_HELMIA9B0X2, FPG_HERA2A4G916, FPG_HERAR
Q0I0X6, FPG_HISS1B0UUX0, FPG_HISS2Q31EB2, FPG_HYDCU
Q5QZC1, FPG_IDILOA6T2R7, FPG_JANMAQ28JI5, FPG_JANSC
A6W7S6, FPG_KINRDB5XTG8, FPG_KLEP3A6TFM6, FPG_KLEP7
Q5FIV8, FPG_LACACQ1G9A3, FPG_LACDAQ049F3, FPG_LACDB
Q041U1, FPG_LACGAA8YWE6, FPG_LACH4Q74IB5, FPG_LACJO
Q9CIK4, FPG_LACLAP42371, FPG_LACLCQ88WV4, FPG_LACPL
C1DBB4, FPG_LARHHQ38VS5, FPG_LATSSQ5X7I9, FPG_LEGPA
Q5ZY18, FPG_LEGPHQ5WYY6, FPG_LEGPLQ6AFJ3, FPG_LEIXX
B1Y3P5, FPG_LEPCPQ1WUN7, FPG_LIGS1Q92BF1, FPG_LISIN
Q71ZA3, FPG_LISMFQ8Y6W7, FPG_LISMOA0L837, FPG_MAGMM
Q65R59, FPG_MANSMA6VSY6, FPG_MARMSA1U749, FPG_MARN8
C6BUX8, FPG_MARSDB7KN75, FPG_METC4Q602J1, FPG_METCA
A9W8R7, FPG_METEPQ1H3I3, FPG_METFKB8IIZ9, FPG_METNO
B1ZGU8, FPG_METPBB1LWY6, FPG_METRJB0UR68, FPG_METS4
B8EKR5, FPG_METSBQ5UQ00, FPG_MIMIVQ2RHE9, FPG_MOOTA
A0QJ66, FPG_MYCA1B1MDL2, FPG_MYCA9P64151, FPG_MYCBO
A1KMR9, FPG_MYCBPC1AG40, FPG_MYCBTP55825, FPG_MYCGE
A4TE57, FPG_MYCGIB8ZRZ2, FPG_MYCLBO69470, FPG_MYCLE
Q6KHS0, FPG_MYCM1B2HJJ6, FPG_MYCMMQ73VL9, FPG_MYCPA
P75402, FPG_MYCPNQ98QQ1, FPG_MYCPUA0QV21, FPG_MYCS2
A3PXU1, FPG_MYCSJA1UED7, FPG_MYCSKQ1BAM5, FPG_MYCSS
A5U6T0, FPG_MYCTAA0PQ49, FPG_MYCUAA1T737, FPG_MYCVP
Q5F8Z9, FPG_NEIG1P57014, FPG_NEIMAP55044, FPG_NEIMB
Q0AD66, FPG_NITECQ82S12, FPG_NITEUQ2YBI1, FPG_NITMU
Q3J7U5, FPG_NITOCQ726D5, FPG_NITV2Q3SWN3, FPG_NITWN
Q5YS09, FPG_NOCFAA1SLU7, FPG_NOCSJB2J5G0, FPG_NOSP7
Q8YP80, FPG_NOSS1Q2GAT0, FPG_NOVADQ8EPE6, FPG_OCEIH
A1BAN2, FPG_PARDPA7HZC4, FPG_PARL1Q7U4V2, FPG_PARMW
B2JCP3, FPG_PARP8B2SXG9, FPG_PARPJQ6MCT3, FPG_PARUW
Q145W8, FPG_PARXLP57910, FPG_PASMUQ6DAV4, FPG_PECAS
C6DIB8, FPG_PECCPQ03GC2, FPG_PEDPAA1AV29, FPG_PELPD
A5D0T6, FPG_PELTSB4RC43, FPG_PHEZHQ8VW76, FPG_PHODP
Q7MY36, FPG_PHOLLQ6LVN0, FPG_PHOPRA1VKP2, FPG_POLNA
B1XS61, FPG_POLNSQ12DZ5, FPG_POLSJA3PB53, FPG_PROM0
A2C0H4, FPG_PROM1A8G2Y9, FPG_PROM2A9BDY5, FPG_PROM4
A2BUV8, FPG_PROM5Q31CK0, FPG_PROM9Q7VDK6, FPG_PROMA
B4F0X6, FPG_PROMHQ7V8Y5, FPG_PROMMQ7V2X4, FPG_PROMP
A2BPD1, FPG_PROMSQ46H41, FPG_PROMTQ48CK1, FPG_PSE14
Q15ZV5, FPG_PSEA6A6UYG0, FPG_PSEA7B7V2S0, FPG_PSEA8
Q02U58, FPG_PSEABQ9L7T2, FPG_PSEAEQ1IGF3, FPG_PSEE4
Q4K4A5, FPG_PSEF5C3K3N6, FPG_PSEFSA4Y028, FPG_PSEMY
A5WAF9, FPG_PSEP1Q3K566, FPG_PSEPFB0KN79, FPG_PSEPG
Q88CQ5, FPG_PSEPKB1J2M4, FPG_PSEPWQ88AH6, FPG_PSESM
Q4ZM34, FPG_PSEU2Q4FUU7, FPG_PSYA2A1SR12, FPG_PSYIN
Q8Y2D7, FPG_RALN1B2UES0, FPG_RALPJB3PZ93, FPG_RHIE6
Q2KDA9, FPG_RHIECQ1MMD9, FPG_RHIJ3Q98BG6, FPG_RHILO
B5ZYK9, FPG_RHILWQ59752, FPG_RHIMEA5VG06, FPG_RHIWR
B6IVU4, FPG_RHOCSC0ZXQ5, FPG_RHOE4Q0S2E0, FPG_RHOJR
C1B2Q5, FPG_RHOOBQ2J2I0, FPG_RHOP2Q07UF4, FPG_RHOP5
Q6NDM1, FPG_RHOPAQ21CD4, FPG_RHOPBQ13EN7, FPG_RHOPS
B3Q620, FPG_RHOPTQ2RMQ2, FPG_RHORTC3PLF5, FPG_RICAE
A8GXR0, FPG_RICB8Q1RJY6, FPG_RICBRA8EZP5, FPG_RICCK
Q92GT4, FPG_RICCNQ4UMW5, FPG_RICFEA8F2H0, FPG_RICM5
C4K2K4, FPG_RICPUB0BUU0, FPG_RICROA8GTA0, FPG_RICRS
B7K1T1, FPG_RIPO1A7NQM8, FPG_ROSCSQ16DL0, FPG_ROSDO
A5UUN1, FPG_ROSS1Q5LWT9, FPG_RUEPOQ1GC55, FPG_RUEST
A1AW02, FPG_RUTMCQ21EE3, FPG_SACD2A4FMJ7, FPG_SACEN
B5EXE0, FPG_SALA4A8M661, FPG_SALAIA9MKN9, FPG_SALAR
Q57IA7, FPG_SALCHB5FM59, FPG_SALDCB5R5F9, FPG_SALEP
B5RGF2, FPG_SALG2B4T9C0, FPG_SALHSB4SXD7, FPG_SALNS
Q5PC09, FPG_SALPAA9MVN0, FPG_SALPBC0Q1W8, FPG_SALPC
B5BI09, FPG_SALPKB4TZX7, FPG_SALSVQ8Z2H2, FPG_SALTI
A4X4F8, FPG_SALTOO54326, FPG_SALTYQ9X981, FPG_SERMA
A8GLE2, FPG_SERP5A1S1S3, FPG_SHEAMB8EDQ9, FPG_SHEB2
A3CYP7, FPG_SHEB5A6WUE9, FPG_SHEB8A9KW47, FPG_SHEB9
Q12SR9, FPG_SHEDOB0TN04, FPG_SHEHHA3QJA8, FPG_SHELP
Q8E8D9, FPG_SHEONA8HA27, FPG_SHEPAB8CVD1, FPG_SHEPW
A0L2N2, FPG_SHESAQ0HDC3, FPG_SHESMQ0HPK4, FPG_SHESR
A1RE25, FPG_SHESWB1KL38, FPG_SHEWMB2TTU9, FPG_SHIB3
Q31UZ1, FPG_SHIBSQ329M2, FPG_SHIDSQ0SYG3, FPG_SHIF8
P64149, FPG_SHIFLQ3YVZ7, FPG_SHISSQ5WEG7, FPG_SHOC1
C3MCY7, FPG_SINFNA6UFF8, FPG_SINMWQ2NQU4, FPG_SODGM
Q01RU9, FPG_SOLUEQ1GN82, FPG_SPHALQ3K028, FPG_STRA1
P64152, FPG_STRA3P64153, FPG_STRA5Q82JU0, FPG_STRAW
Q9ZBQ6, FPG_STRCOB1VYY1, FPG_STRGGB4SRN0, FPG_STRM5
B2FU49, FPG_STRMKP55045, FPG_STRMUQ9A131, FPG_STRP1
P0DB14, FPG_STRP3Q5XDE4, FPG_STRP6Q8P250, FPG_STRP8
Q48UU6, FPG_STRPMQ97R61, FPG_STRPNP0DB15, FPG_STRPQ
Q8DQ33, FPG_STRR6Q5M0P0, FPG_STRT1Q5M576, FPG_STRT2
A4VRM9, FPG_STUS1Q67R59, FPG_SYMTHQ3A3F2, FPG_SYNC1
P95744, FPG_SYNELQ08079, FPG_SYNP6Q0AVE3, FPG_SYNWW
P74290, FPG_SYNY3C5BLG1, FPG_TERTTQ47S77, FPG_THEFY
B9L1Z5, FPG_THERPQ72HN2, FPG_THET2O50606, FPG_THET8
P59065, FPG_THEVBQ3SLR9, FPG_THIDAB8GUQ6, FPG_THISH
Q117D2, FPG_TRIEIQ3MDP1, FPG_TRIV2Q9PQ76, FPG_UREPA
C5CYZ1, FPG_VARPSA5CX90, FPG_VESOHB7VHK6, FPG_VIBA3
A7MSN3, FPG_VIBC1A5F407, FPG_VIBC3Q9KVC5, FPG_VIBCH
C3LQI3, FPG_VIBCMQ87T81, FPG_VIBPAQ8DDY4, FPG_VIBVU
Q7MPS3, FPG_VIBVYQ73G10, FPG_WOLPMB3CM71, FPG_WOLPP
Q5GS47, FPG_WOLTRC0R4I6, FPG_WOLWRQ8PEQ4, FPG_XANAC
Q4UNU6, FPG_XANC8B0RZ50, FPG_XANCBQ8P3C4, FPG_XANCP
Q3BM92, FPG_XANE5Q2P8V2, FPG_XANOMB2STU3, FPG_XANOP
Q5H667, FPG_XANORA7IKJ3, FPG_XANP2P64154, FPG_XYLFA
P64155, FPG_XYLFTA1JHR7, FPG_YERE8A7FCT7, FPG_YERP3
Q1C270, FPG_YERPAB2JYN6, FPG_YERPBQ8ZJP0, FPG_YERPE
A9R677, FPG_YERPGQ1CD05, FPG_YERPNA4TSD4, FPG_YERPP
Q66GD3, FPG_YERPSB1JQX0, FPG_YERPYQ9X3X1, FPG_ZYMMO
Q96FI4, NEIL1_HUMANQ8K4Q6, NEIL1_MOUSEQ6IE77, NEIL2_BOVIN
Q969S2, NEIL2_HUMANQ6R2P8, NEIL2_MOUSEQ5RAJ7, NEIL2_PONAB
Q3MHN7, NEIL3_BOVINQ8TAT5, NEIL3_HUMANQ8K203, NEIL3_MOUSE
A0A1L8HU22, NEIL3_XENLAQ9SIC4, NTH1_ARATHP31378, NTH1_YEAST
B9DFZ0, NTH2_ARATHQ08214, NTH2_YEASTQ2KID2, NTH_BOVIN
P54137, NTH_CAEELA7M7B9, NTH_CHICKC8VC05, NTH_EMENI
Q8SRB8, NTH_ENCCUP78549, NTH_HUMANO35980, NTH_MOUSE
Q09907, NTH_SCHPOO66612, OGG1_AQUAEQ9FNY7, OGG1_ARATH
O29876, OGG1_ARCFUQ9V3I8, OGG1_DROMEQ8R689, OGG1_FUSNN
O15527, OGG1_HUMANB1L640, OGG1_KORCOQ58134, OGG1_METJA
A4YHC9, OGG1_METS5O27397, OGG1_METTHO08760, OGG1_MOUSE
Q6L1T6, OGG1_PICTOO70249, OGG1_RATQ97ZK2, OGG1_SACS2
Q4J929, OGG1_SULACC3N5H5, OGG1_SULIAC4KH41, OGG1_SULIK
C3MPU9, OGG1_SULILC3MUW1, OGG1_SULIMC3NHM4, OGG1_SULIN
C3NE39, OGG1_SULIYQ972A8, OGG1_SULTOQ9HM55, OGG1_THEAC
Q9X2E1, OGG1_THEMAB9K7J6, OGG1_THENNA5ILP7, OGG1_THEP1
B1LAK2, OGG1_THESQQ97CP1, OGG1_THEVOP53397, OGG1_YEAST
Q9SJQ6, ROS1_ARATHP02350, RS3A_XENLAP47835, RS3B_XENLA
P79891, RS3_AMBMEQ3T169, RS3_BOVINE2RH47, RS3_CANLF
P23396, RS3_HUMANQ90YS2, RS3_ICTPUP62908, RS3_MOUSE
Q0Z8U2, RS3_PIGQ5R465, RS3_PONABG1TNM3, RS3_RABIT
P62909, RS3_RATO26314, UREND_METTH

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