ENZYME entry: EC 4.3.3.5
| Accepted Name |
|---|
| 4'-demethylrebeccamycin synthase.
|
| Alternative Name(s) |
|---|
| Arcyriaflavin A N-glycosyltransferase. |
| Reaction catalysed |
|---|
| 4'-O-demethylrebeccamycin + H(2)O <=> dichloro-arcyriaflavin A + beta-D-glucose |
| Comment(s) |
|---|
- This enzyme catalyzes a step in the biosynthesis of rebeccamycin,
an indolocarbazole alkaloid produced by the bacterium Lechevalieria
aerocolonigenes.
- The enzyme is a glycosylase, and acts in the reverse direction to
that shown.
- It has a wide substrate range, and was shown to glycosylate several
substrates, including the staurosporine aglycone, EJG-III-108A,
J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole.
|
| Cross-references |
|---|
| BRENDA | 4.3.3.5 |
| EC2PDB | 4.3.3.5 |
| ExplorEnz | 4.3.3.5 |
| PRIAM enzyme-specific profiles | 4.3.3.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.3.3.5 |
| IUBMB Enzyme Nomenclature | 4.3.3.5 |
| IntEnz | 4.3.3.5 |
| MEDLINE | Find literature relating to 4.3.3.5 |
| MetaCyc | 4.3.3.5 |
| UniProtKB/Swiss-Prot |
|
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