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ENZYME entry: EC 4.3.3.5

Accepted Name
4'-demethylrebeccamycin synthase.
Alternative Name(s)
Arcyriaflavin A N-glycosyltransferase.
Reaction catalysed
4'-O-demethylrebeccamycin + H(2)O <=> dichloro-arcyriaflavin A + beta-D-glucose
Comment(s)
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • The enzyme is a glycosylase, and acts in the reverse direction to that shown.
  • It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole.
Cross-references
BRENDA4.3.3.5
EC2PDB4.3.3.5
ExplorEnz4.3.3.5
PRIAM enzyme-specific profiles4.3.3.5
KEGG Ligand Database for Enzyme Nomenclature4.3.3.5
IUBMB Enzyme Nomenclature4.3.3.5
IntEnz4.3.3.5
MEDLINEFind literature relating to 4.3.3.5
MetaCyc4.3.3.5
Rhea expert-curated reactions4.3.3.5
UniProtKB/Swiss-Prot
Q8KHE4, REBG_LENAE

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