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ENZYME

ENZYME entry: EC 4.3.3.6

Accepted Name
pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
Reaction catalysed
aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
Comment(s)
  • The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel.
  • The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.
  • The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.
Cross-references
BRENDA4.3.3.6
EC2PDB4.3.3.6
ExplorEnz4.3.3.6
PRIAM enzyme-specific profiles4.3.3.6
KEGG Ligand Database for Enzyme Nomenclature4.3.3.6
IUBMB Enzyme Nomenclature4.3.3.6
IntEnz4.3.3.6
MEDLINEFind literature relating to 4.3.3.6
MetaCyc4.3.3.6
Rhea expert-curated reactions4.3.3.6
UniProtKB/Swiss-Prot
O80448, PDX11_ARATHQ69LA6, PDX11_ORYSJQ8W3D0, PDX12_ORYSJ
Q8L940, PDX13_ARATHO59905, PDX1_CERNCQ54J47, PDX1_DICDI
Q9UW83, PDX1_EMENIQ9AT63, PDX1_GINBIQ39963, PDX1_HEVBR
Q9C1K6, PDX1_NEUCRQ9FT25, PDX1_PHAVUP0DMS0, PDX1_PLABE
C6KT50, PDX1_PLAF7O14027, PDX1_SCHPOQ41348, PDX1_STELP
Q8WPW2, PDX1_SUBDOQ8LAD0, PDX2_ARATHQ54J48, PDX2_DICDI
Q4PJX5, PDX2_PLABEQ8IIK4, PDX2_PLAF7A3MZT8, PDXS_ACTP2
B3GXB6, PDXS_ACTP7B0BUD0, PDXS_ACTPJQ9YFK2, PDXS_AERPE
B7GFL8, PDXS_ANOFWO29742, PDXS_ARCFUC3P8Q3, PDXS_BACAA
C3LIY7, PDXS_BACACQ81W27, PDXS_BACANB7JJC6, PDXS_BACC0
Q73FJ5, PDXS_BACC1B7IS29, PDXS_BACC2C1ES17, PDXS_BACC3
B7HII3, PDXS_BACC4B7HPS6, PDXS_BACC7A7GJS8, PDXS_BACCN
B9IYH8, PDXS_BACCQQ81JC6, PDXS_BACCRQ63HF8, PDXS_BACCZ
Q6HQ05, PDXS_BACHKQ65PL2, PDXS_BACLDA9VM99, PDXS_BACMK
A8FAD5, PDXS_BACP2P37527, PDXS_BACSUA7Z0D3, PDXS_BACVZ
B8DWP6, PDXS_BIFA0A1A3A5, PDXS_BIFAAB3DT80, PDXS_BIFLD
Q8G574, PDXS_BIFLOB7GUB5, PDXS_BIFLSQ8RBJ3, PDXS_CALS4
A9WFT9, PDXS_CHLAAB8G663, PDXS_CHLADB9LIK3, PDXS_CHLSY
Q97LG7, PDXS_CLOABA7GH18, PDXS_CLOBLB1KYX5, PDXS_CLOBM
Q84IL8, PDXS_CLONOP81356, PDXS_CLOPAP60800, PDXS_CORDI
Q8FPJ9, PDXS_COREFP82134, PDXS_CORGLB1VDJ3, PDXS_CORU7
Q6A948, PDXS_CUTAKQ3Z9H3, PDXS_DEHM1A5FS82, PDXS_DEHMB
Q3ZZB8, PDXS_DEHMCQ9RUL7, PDXS_DEIRAB8D3X7, PDXS_DESA1
B8J2D5, PDXS_DESDAB8FZR3, PDXS_DESHDQ24PK7, PDXS_DESHY
B5YF85, PDXS_DICT6B8E121, PDXS_DICTDB0TZ17, PDXS_FRAP2
Q14IU8, PDXS_FRAT1A7NDQ3, PDXS_FRATFQ2A260, PDXS_FRATH
B2SDL5, PDXS_FRATMA0Q5I1, PDXS_FRATNQ0BKT2, PDXS_FRATO
Q5NHE6, PDXS_FRATTO69190, PDXS_FRATUA4IZB5, PDXS_FRATW
Q8RDP7, PDXS_FUSNNQ5L3Y2, PDXS_GEOKAC5D337, PDXS_GEOSW
A4IJ94, PDXS_GEOTNQ7VL86, PDXS_HAEDUQ4QJU5, PDXS_HAEI8
A5UBN2, PDXS_HAEIEA5UF86, PDXS_HAEIGP45293, PDXS_HAEIN
Q9KGN6, PDXS_HALH5B9LRS6, PDXS_HALLTQ5V1G7, PDXS_HALMA
B0R6D5, PDXS_HALS3Q9HP57, PDXS_HALSAQ18F41, PDXS_HALWD
B0TAQ4, PDXS_HELMIA9B891, PDXS_HERA2A2BLL5, PDXS_HYPBU
Q6AFB9, PDXS_LEIXXQ929R9, PDXS_LISINC1KX53, PDXS_LISMC
Q71XR3, PDXS_LISMFB8DH17, PDXS_LISMHQ8Y5G2, PDXS_LISMO
A0AKK8, PDXS_LISW6B9E8T2, PDXS_MACCJA6UWM0, PDXS_META3
Q8TQH6, PDXS_METACQ58090, PDXS_METJAQ8TVL8, PDXS_METKA
A2SPJ9, PDXS_METLZA4G086, PDXS_METM5A9A8I8, PDXS_METM6
A6VI92, PDXS_METM7Q8PUA5, PDXS_METMAQ6M115, PDXS_METMP
A4YI11, PDXS_METS5Q2NI73, PDXS_METSTO26762, PDXS_METTH
Q50841, PDXS_METVAA6UR91, PDXS_METVSA0QIC8, PDXS_MYCA1
P60795, PDXS_MYCBOA1KLV6, PDXS_MYCBPC1AF77, PDXS_MYCBT
B8ZUG3, PDXS_MYCLBO07145, PDXS_MYCLEQ73WF0, PDXS_MYCPA
A0QWG8, PDXS_MYCS2A5U5V7, PDXS_MYCTAP9WII8, PDXS_MYCTO
P9WII9, PDXS_MYCTUQ3INE8, PDXS_NATPDB2A2Z7, PDXS_NATTJ
Q8L1A8, PDXS_NIACIQ5YTD8, PDXS_NOCFAQ8EN03, PDXS_OCEIH
Q6MEN8, PDXS_PARUWQ9CLJ6, PDXS_PASMUQ6L2D8, PDXS_PICTO
Q9V0J7, PDXS_PYRABQ8ZUF0, PDXS_PYRAEA4WHH6, PDXS_PYRAR
A3MSN0, PDXS_PYRCJQ8U0Q6, PDXS_PYRFUO59080, PDXS_PYRHO
A7NQB8, PDXS_ROSCSA5UY94, PDXS_ROSS1B8I363, PDXS_RUMCH
Q9UWX3, PDXS_SACS2A8LWZ4, PDXS_SALAIA4X5V3, PDXS_SALTO
Q5WKW2, PDXS_SHOC1A7WYT1, PDXS_STAA1A6TYZ5, PDXS_STAA2
Q2FJC1, PDXS_STAA3Q2G0Q1, PDXS_STAA8A5IQ72, PDXS_STAA9
Q5HIF5, PDXS_STAACA6QEH1, PDXS_STAAEP60797, PDXS_STAAM
P60798, PDXS_STAANQ6GJF0, PDXS_STAARQ6GBW9, PDXS_STAAS
A8YZL5, PDXS_STAATP60799, PDXS_STAAWB9DKX7, PDXS_STACT
Q5HRN5, PDXS_STAEQQ8CQV7, PDXS_STAESQ4L3H8, PDXS_STAHJ
Q49V28, PDXS_STAS1Q827U0, PDXS_STRAWQ9L286, PDXS_STRCO
Q04JN5, PDXS_STRP2B5E5W1, PDXS_STRP4C1C863, PDXS_STRP7
B1ICP9, PDXS_STRPIB8ZL14, PDXS_STRPJQ97PX2, PDXS_STRPN
Q8DP71, PDXS_STRR6C1CF50, PDXS_STRZJC1CLG7, PDXS_STRZP
C1CQQ0, PDXS_STRZTQ4J8L3, PDXS_SULACC3N6C8, PDXS_SULIA
C4KHU3, PDXS_SULIKC3MQK8, PDXS_SULILC3MW86, PDXS_SULIM
C3NGV8, PDXS_SULINC3NET6, PDXS_SULIYQ971B3, PDXS_SULTO
Q2LXR2, PDXS_SYNASQ9HKS5, PDXS_THEACC5A4G9, PDXS_THEGJ
Q5JFR1, PDXS_THEKOQ9WYU4, PDXS_THEMAB6YVQ7, PDXS_THEON
A5IJU8, PDXS_THEP1B0KAS1, PDXS_THEP3B0K4N7, PDXS_THEPX
B1L920, PDXS_THESQQ72KG1, PDXS_THET2Q5SKD9, PDXS_THET8
Q979Y3, PDXS_THEVOQ73QI7, PDXS_TREDEQ83HM5, PDXS_TROW8
Q83MZ9, PDXS_TROWTA0LUK9, PDXT_ACIC1A3MZT9, PDXT_ACTP2
B3GXB7, PDXT_ACTP7B0BUD1, PDXT_ACTPJQ9YFK4, PDXT_AERPE
B7GFL9, PDXT_ANOFWO29741, PDXT_ARCFUA0JXB5, PDXT_ARTS2
B6YQU3, PDXT_AZOPCC3P8Q4, PDXT_BACAAC3LIY8, PDXT_BACAC
A0R890, PDXT_BACAHQ81W26, PDXT_BACANB7JJC7, PDXT_BACC0
Q73FJ4, PDXT_BACC1B7IS30, PDXT_BACC2C1ES18, PDXT_BACC3
B7HII4, PDXT_BACC4B7HPS7, PDXT_BACC7A7GJS9, PDXT_BACCN
B9IYH9, PDXT_BACCQQ81JC5, PDXT_BACCRQ63HF7, PDXT_BACCZ
Q6HQ04, PDXT_BACHKQ65PL1, PDXT_BACLDA9VMA0, PDXT_BACMK
A8FAD6, PDXT_BACP2P37528, PDXT_BACSUA7Z0D4, PDXT_BACVZ
A1A3A4, PDXT_BIFAAQ8G575, PDXT_BIFLOC0ZH53, PDXT_BREBN
B9MKY8, PDXT_CALBDA8MAY1, PDXT_CALMQQ8RBJ4, PDXT_CALS4
A4XIB6, PDXT_CALS8Q3A8Q0, PDXT_CARHZA0RTP4, PDXT_CENSY
A9WFU0, PDXT_CHLAAB8G664, PDXT_CHLADB9LIK4, PDXT_CHLSY
A5CS10, PDXT_CLAM3B0REB6, PDXT_CLASEQ97LG6, PDXT_CLOAB
A6M3G5, PDXT_CLOB8B1KYX4, PDXT_CLOBMB9E3V5, PDXT_CLOK1
A5MZY0, PDXT_CLOK5Q6NK10, PDXT_CORDIA4QCC4, PDXT_CORGB
Q8NS90, PDXT_CORGLQ4JVD5, PDXT_CORJKQ6A947, PDXT_CUTAK
Q3Z8V9, PDXT_DEHM1A5FRL6, PDXT_DEHMBQ3ZX06, PDXT_DEHMC
Q1IZC9, PDXT_DEIGDQ9RUL8, PDXT_DEIRAB1I158, PDXT_DESAP
B8FZR4, PDXT_DESHDQ24PK8, PDXT_DESHYA4J0G0, PDXT_DESRM
B5YF84, PDXT_DICT6B8E120, PDXT_DICTDB1YGC2, PDXT_EXIS2
A7HNV0, PDXT_FERNBQ0RNV0, PDXT_FRAAAQ2JD98, PDXT_FRACC
B0TZ16, PDXT_FRAP2A8KZF0, PDXT_FRASNQ14IU7, PDXT_FRAT1
A7NDQ2, PDXT_FRATFQ2A261, PDXT_FRATHB2SDL4, PDXT_FRATM
A0Q5I2, PDXT_FRATNQ0BKT3, PDXT_FRATOQ5NHE5, PDXT_FRATT
A4IZB4, PDXT_FRATWQ5L3Y1, PDXT_GEOKAP83813, PDXT_GEOSE
C5D338, PDXT_GEOSWA4IJ95, PDXT_GEOTNQ7VL87, PDXT_HAEDU
Q4QJU4, PDXT_HAEI8A5UBN1, PDXT_HAEIEA5UF87, PDXT_HAEIG
P45294, PDXT_HAEINQ9KGN5, PDXT_HALH5B9LSC8, PDXT_HALLT
Q5UZW7, PDXT_HALMAB0R879, PDXT_HALS3Q9HMD2, PDXT_HALSA
Q18KL6, PDXT_HALWDA9B890, PDXT_HERA2A2BLL6, PDXT_HYPBU
A8A8T7, PDXT_IGNH4A6WCI3, PDXT_KINRDB1L4Z3, PDXT_KORCO
Q1IQH8, PDXT_KORVEC5CG73, PDXT_KOSOTQ6AFB8, PDXT_LEIXX
Q929R8, PDXT_LISINC1KX54, PDXT_LISMCQ71XR2, PDXT_LISMF
B8DH16, PDXT_LISMHQ8Y5G1, PDXT_LISMOA0AKK9, PDXT_LISW6
A6UWZ3, PDXT_META3Q8TQH7, PDXT_METACQ0W8A8, PDXT_METAR
A7I472, PDXT_METB6Q465J4, PDXT_METBFQ12YR6, PDXT_METBU
Q2FTH1, PDXT_METHJQ59055, PDXT_METJAQ8TWH2, PDXT_METKA
A2SPK0, PDXT_METLZA4G0R6, PDXT_METM5A9A909, PDXT_METM6
A6VHR9, PDXT_METM7Q8PUA4, PDXT_METMAA3CRE5, PDXT_METMJ
P0C036, PDXT_METMPB8GE19, PDXT_METPEA5UK48, PDXT_METS3
A4YI12, PDXT_METS5Q2NGI4, PDXT_METSTO26292, PDXT_METTH
A0B7N4, PDXT_METTPA6UQT7, PDXT_METVSQ2RMI9, PDXT_MOOTA
A0QIC6, PDXT_MYCA1B1MCJ8, PDXT_MYCA9Q7TY92, PDXT_MYCBO
A1KLV4, PDXT_MYCBPC1AF75, PDXT_MYCBTQ9CCT5, PDXT_MYCLE
B2HN48, PDXT_MYCMMQ73WF2, PDXT_MYCPAA0QWH0, PDXT_MYCS2
A3PYU8, PDXT_MYCSJA1UF87, PDXT_MYCSKQ1B9S6, PDXT_MYCSS
A5U5V5, PDXT_MYCTAP9WII6, PDXT_MYCTOP9WII7, PDXT_MYCTU
A0PSY6, PDXT_MYCUAA1T876, PDXT_MYCVPQ3IU60, PDXT_NATPD
Q8L1A7, PDXT_NIACIA9A4S0, PDXT_NITMSQ5YTE0, PDXT_NOCFA
A1SJA2, PDXT_NOCSJQ8EN04, PDXT_OCEIHQ04F27, PDXT_OENOB
A1R728, PDXT_PAEATQ6MEN7, PDXT_PARUWQ9CLJ5, PDXT_PASMU
A5D6D2, PDXT_PELTSQ6L1R3, PDXT_PICTOB8H9E0, PDXT_PSECP
A8F840, PDXT_PSELTQ9V0J6, PDXT_PYRABQ8ZUE9, PDXT_PYRAE
A4WHH5, PDXT_PYRARA3MSM9, PDXT_PYRCJQ8TH23, PDXT_PYRFU
O59079, PDXT_PYRHOA1RU67, PDXT_PYRILB1YB90, PDXT_PYRNV
A9WSE8, PDXT_RENSMQ0S1D2, PDXT_RHOJRC1B4C5, PDXT_RHOOB
A7NQB7, PDXT_ROSCSA5UY93, PDXT_ROSS1Q1AWE7, PDXT_RUBXD
B8I364, PDXT_RUMCHA4FBA2, PDXT_SACENQ9UWX4, PDXT_SACS2
A8LWZ5, PDXT_SALAIA4X5V4, PDXT_SALTOQ5WKW1, PDXT_SHOC1
Q02CB5, PDXT_SOLUEA7WYT2, PDXT_STAA1A6TYZ6, PDXT_STAA2
Q2FJC0, PDXT_STAA3Q2G0Q0, PDXT_STAA8A5IQ73, PDXT_STAA9
Q2YSE1, PDXT_STAABQ5HIF4, PDXT_STAACA6QEH2, PDXT_STAAE
Q99W83, PDXT_STAAMQ7A7A1, PDXT_STAANQ6GJE9, PDXT_STAAR
Q6GBW8, PDXT_STAASA8YZL6, PDXT_STAATQ7A1R6, PDXT_STAAW
B9DKX8, PDXT_STACTQ5HRN4, PDXT_STAEQQ8CQV8, PDXT_STAES
Q4L3H9, PDXT_STAHJA3DM32, PDXT_STAMFQ49V29, PDXT_STAS1
Q81ZV5, PDXT_STRAWQ9L287, PDXT_STRCOB1W3G0, PDXT_STRGG
Q04JN6, PDXT_STRP2B5E5W0, PDXT_STRP4C1C862, PDXT_STRP7
B1ICP8, PDXT_STRPIB8ZL13, PDXT_STRPJQ97PX3, PDXT_STRPN
B2IQT4, PDXT_STRPSQ8DP72, PDXT_STRR6C1CF49, PDXT_STRZJ
C1CLG6, PDXT_STRZPC1CQQ1, PDXT_STRZTQ4J8L2, PDXT_SULAC
C3N6C7, PDXT_SULIAC4KHU2, PDXT_SULIKC3MQK7, PDXT_SULIL
C3MW85, PDXT_SULIMC3NGV9, PDXT_SULINC3NET5, PDXT_SULIY
Q971B2, PDXT_SULTOQ2LXR3, PDXT_SYNASB7IEZ6, PDXT_THEAB
Q9HM60, PDXT_THEACQ47N39, PDXT_THEFYC5A4H0, PDXT_THEGJ
Q5JFR2, PDXT_THEKOA6LP41, PDXT_THEM4Q9WYU3, PDXT_THEMA
B9KBI1, PDXT_THENNB6YVQ8, PDXT_THEONA5IJU9, PDXT_THEP1
B0KAS0, PDXT_THEP3B0K4N6, PDXT_THEPXB1L921, PDXT_THESQ
Q72KF8, PDXT_THET2Q5SKD6, PDXT_THET8Q97CP5, PDXT_THEVO
Q83HM6, PDXT_TROW8Q83GK3, PDXT_TROWTQ03144, SNO1_YEAST
P53823, SNO2_YEASTP43544, SNO3_YEASTQ03148, SNZ1_YEAST
P53824, SNZ2_YEASTP43545, SNZ3_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-