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ENZYME

ENZYME entry: EC 4.4.1.13

PURL: https://purl.expasy.org/enzyme/EC/4.4.1.13
Accepted Name
cysteine-S-conjugate beta-lyase
Alternative Name(s)
alkylcysteine lyase
alkyl cysteine lyase
cystathionine beta-lyase
cystine lyase
L-cysteine-S-conjugate thiol-lyase (deaminating)
S-alkylcysteinase
S-alkylcysteine lyase
S-alkyl-L-cysteine lyase
S-alkyl-L-cysteine sulfoxide lyase
Reaction catalysed
an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • The enzyme is promiscuous regarding the moiety conjugated to L-cysteine, and can accept both aliphatic and aromatic substitutions.
  • The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • While bacteria and plants have dedicated enzymes, all of the animal enzymes discovered thus far are bifunctional, most of which also act as aminotransferases.
  • Formerly EC 4.4.1.6 and EC 4.4.1.8.
Cross-references
BRENDA4.4.1.13
EC2PDB4.4.1.13
ExplorEnz4.4.1.13
KEGG Ligand Database for Enzyme Nomenclature4.4.1.13
IUBMB Enzyme Nomenclature4.4.1.13
MEDLINEFind literature relating to 4.4.1.13
MetaCyc4.4.1.13
Rhea expert-curated reactions4.4.1.13
UniProtKB/Swiss-Prot
Q08432, CBL_BACSUQ93QC6, CBL_CORGTQ64HC5, CBL_CORST
A0A0M3VI47, CBL_MIMPUP63503, CBL_MYCBOQ9CBM9, CBL_MYCLE
P9WQ82, CBL_MYCTOP9WQ83, CBL_MYCTUQ1K8G0, CBL_NEUCR
O94350, CBL_SCHPOQ5SHW0, CBL_THET8Q16773, KAT1_HUMAN
Q8BTY1, KAT1_MOUSEQ08415, KAT1_RATQ0P5G4, KAT3_BOVIN
Q7T3E5, KAT3_DANREQ6YP21, KAT3_HUMANQ71RI9, KAT3_MOUSE
Q58FK9, KAT3_RATQ54KM6, KAT_DICDIP23256, MALY_ECOLI
P53780, METC_ARATHO31632, METC_BACSUQ07703, METC_BORAV
Q83A83, METC_COXBUP06721, METC_ECOLIP44527, METC_HAEIN
P0A4K2, METC_LACLAP0C2T9, METC_LACLCA2RM21, METC_LACLM
P85217, METC_PAPLAQ52811, METC_RHIJ3P18949, METC_SALTY
Q4L332, METC_STAHJP43623, METC_YEASTU6BYK3, MIMOS_MIMPU
P53101, STR3_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-