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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.4.1.13

Accepted Name
Cysteine-S-conjugate beta-lyase.
Alternative Name(s)
Alkyl cysteine lyase.
Alkylcysteine lyase.
Cystathionine beta-lyase.
Cystine lyase.
L-cysteine-S-conjugate thiol-lyase (deaminating).
S-alkyl-L-cysteine lyase.
S-alkyl-L-cysteine sulfoxide lyase.
S-alkylcysteinase.
S-alkylcysteine lyase.
Reaction catalysed
An L-cysteine-S-conjugate + H(2)O <=> RSH + NH(3) + pyruvate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • The enzyme is promiscuous regarding the moiety conjugated to L-cysteine, and can accept both aliphatic and aromatic substitutions.
  • The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • While bacteria and plants have dedicated enzymes, all of the animal enzymes discovered thus far are bifunctional, most of which also act as aminotransferases.
  • Formerly EC 4.4.1.6 and EC 4.4.1.8.
Cross-references
BRENDA4.4.1.13
EC2PDB4.4.1.13
ExplorEnz4.4.1.13
PRIAM enzyme-specific profiles4.4.1.13
KEGG Ligand Database for Enzyme Nomenclature4.4.1.13
IUBMB Enzyme Nomenclature4.4.1.13
IntEnz4.4.1.13
MEDLINEFind literature relating to 4.4.1.13
MetaCyc4.4.1.13
UniProtKB/Swiss-Prot
Q08432, CBL_BACSU;  Q93QC6, CBL_CORGT;  P63503, CBL_MYCBO;  
Q9CBM9, CBL_MYCLE;  P9WQ82, CBL_MYCTO;  P9WQ83, CBL_MYCTU;  
Q1K8G0, CBL_NEUCR;  O94350, CBL_SCHPO;  Q5SHW0, CBL_THET8;  
Q16773, KAT1_HUMAN;  Q8BTY1, KAT1_MOUSE;  Q08415, KAT1_RAT;  
Q0P5G4, KAT3_BOVIN;  Q7T3E5, KAT3_DANRE;  Q6YP21, KAT3_HUMAN;  
Q71RI9, KAT3_MOUSE;  Q58FK9, KAT3_RAT;  Q54KM6, KAT_DICDI;  
P23256, MALY_ECOLI;  P53780, METC_ARATH;  O31632, METC_BACSU;  
Q07703, METC_BORAV;  Q83A83, METC_COXBU;  P06721, METC_ECOLI;  
P44527, METC_HAEIN;  P0A4K2, METC_LACLA;  P0C2T9, METC_LACLC;  
A2RM21, METC_LACLM;  P85217, METC_PAPLA;  Q52811, METC_RHIL3;  
P18949, METC_SALTY;  Q4L332, METC_STAHJ;  P43623, METC_YEAST;  
P53101, STR3_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-