A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.4.1.13
| Accepted Name |
|---|
| Cysteine-S-conjugate beta-lyase.
|
| Alternative Name(s) |
|---|
| Alkyl cysteine lyase. |
| Alkylcysteine lyase. |
| Cystathionine beta-lyase. |
| Cystine lyase. |
| L-cysteine-S-conjugate thiol-lyase (deaminating). |
| S-alkyl-L-cysteine lyase. |
| S-alkyl-L-cysteine sulfoxide lyase. |
| S-alkylcysteinase. |
| S-alkylcysteine lyase. |
| Reaction catalysed |
|---|
| An L-cysteine-S-conjugate + H(2)O <=> RSH + NH(3) + pyruvate |
| Cofactor(s) |
|---|
| Pyridoxal 5'-phosphate.
|
| Comment(s) |
|---|
- A pyridoxal 5'-phosphate protein.
- The enzyme is promiscuous regarding the moiety conjugated to
L-cysteine, and can accept both aliphatic and aromatic substitutions.
- The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an
unstable enamine product that tautomerizes to an imine form, which
undergoes a hydrolytic deamination to form pyruvate and ammonia.
- While bacteria and plants have dedicated enzymes, all of the animal
enzymes discovered thus far are bifunctional, most of which also act
as aminotransferases.
- Formerly EC 4.4.1.6 and EC 4.4.1.8.
|
| Cross-references |
|---|
| BRENDA | 4.4.1.13 |
| EC2PDB | 4.4.1.13 |
| ExplorEnz | 4.4.1.13 |
| PRIAM enzyme-specific profiles | 4.4.1.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.4.1.13 |
| IUBMB Enzyme Nomenclature | 4.4.1.13 |
| IntEnz | 4.4.1.13 |
| MEDLINE | Find literature relating to 4.4.1.13 |
| MetaCyc | 4.4.1.13 |
| UniProtKB/Swiss-Prot |
| Q08432, CBL_BACSU; | Q93QC6, CBL_CORGT; | P63503, CBL_MYCBO; |
| Q9CBM9, CBL_MYCLE; | P9WQ82, CBL_MYCTO; | P9WQ83, CBL_MYCTU; |
| Q1K8G0, CBL_NEUCR; | O94350, CBL_SCHPO; | Q5SHW0, CBL_THET8; |
| Q16773, KAT1_HUMAN; | Q8BTY1, KAT1_MOUSE; | Q08415, KAT1_RAT; |
| Q0P5G4, KAT3_BOVIN; | Q7T3E5, KAT3_DANRE; | Q6YP21, KAT3_HUMAN; |
| Q71RI9, KAT3_MOUSE; | Q58FK9, KAT3_RAT; | Q54KM6, KAT_DICDI; |
| P23256, MALY_ECOLI; | P53780, METC_ARATH; | O31632, METC_BACSU; |
| Q07703, METC_BORAV; | Q83A83, METC_COXBU; | P85217, METC_CRYLA; |
| P06721, METC_ECOLI; | P44527, METC_HAEIN; | P0A4K2, METC_LACLA; |
| P0C2T9, METC_LACLC; | A2RM21, METC_LACLM; | Q52811, METC_RHIL3; |
| P18949, METC_SALTY; | Q4L332, METC_STAHJ; | P43623, METC_YEAST; |
| P53101, STR3_YEAST; |
|
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